 | | Vol. 13.43 – 2 November, 2021 |
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| Bone marrow-derived MSC treatment was safe and well tolerated but did not show an effect on gadolinium-enhancing lesions, an MRI surrogate marker of acute inflammation, in patients with active forms of multiple sclerosis, at week 24.
[Lancet Neurology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a material and culture system for modifying and measuring the degree to which cells retained cumulative effects of mechanosensing.
[Nature Communications] |
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| Scientists applied the recently established mixed neuroglial primary cell culture of the rat superficial dorsal horn (SDH) to investigate the effects of adipose MSCs on the inflammatory response of SDH cells.
[Molecular Neurobiology] |
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| Investigators explored breast cancer and glioblastoma multiforme cell lines MDA-MB-321 and U87-MG and evaluated the impact of hyaluronan on tumor-promoting features of bone marrow-derived MSCs, and their interaction with tumor cells.
[Scientific Reports] |
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| Researchers demonstrated that exosomes extracted from bone marrow MSCs (BMSC-exo) significantly promoted HFOB1.19 differentiation to osteoblasts.
[Bioengineered] |
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| Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. The authors found that lung MSCs at the pre-metastatic stage possessed potent metastasis-promoting activity.
[Nature Communications] |
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| Scientists found that circPRKAR1B enhanced osteosarcoma (OS) cell proliferation, migration, and promoted OS epithelial-mesenchymal transition.
[Cell Death & Disease] |
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| Investigators examined the function of Notch signaling in intrauterine adhesions treatment with human amniotic MSC (hAMSC) transplantation, and found that it mediated the differentiation of hAMSCs into endometrial epithelial cells, thus promoting endometrial regeneration and repair.
[Journal of Cellular and Molecular Medicine] |
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| The authors investigated the effects of wild-type p53-induce phosphatase 1 (Wip1) on regulating MSCs immunosuppressive capacities in type 1 diabetes mellitus mice.
[Cell Death Discovery] |
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| Researchers measured changes in mechanistic target of rapamycin complex 1 signaling, the ubiquitin–proteasome system, and autophagy-lysosome system-related factors after a single intramuscular injection of MSCs with green fluorescence protein into mouse muscles.
[Scientific Reports] |
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| The authors evaluated the capability of human umbilical cord MSCs mixed with hyaluronan to treat osteoarthritis in a rabbit model.
[Stem Cells International] |
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| Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.
[Stem Cells International] |
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| After induction of the Alzheimer’s disease model, rats were transplanted with deferoxamine-preconditioned adipose-derived MSCs or untreated cells.
[Life Sciences] |
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| The authors summarize some of the knowledge regarding the presence of adipose tissue in particular tissues, describing the composition of its adipogenic precursors, and the interactions responsible for the development of organ pathologies.
[Reviews in Endocrine & Metabolic Disorders] |
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| Investigators review the studies on exosomes secreted by MSCs (MSC-EXOs) for drug delivery, summarize the characteristics of MSC-EXOs, and introduce the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.
[Stem Cell Research & Therapy] |
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| Due to paucity of standard protocols in extraction procedures of extracellular vesicles (EVs) and their pharmacological properties and mechanisms, the development of new EV dependent therapies is challenging.
[Molecular Neurobiology] |
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| Vitti Labs announced that the US FDA has approved its Investigational New Drug (IND) application to conduct Phase II Clinical Trials using a combination of umbilical cord MSCs and umbilical cord MSC exosomes for the treatment of Acute Respiratory Distress Syndrome associated with COVID-19.
[Vitti Labs (PR Newswire, Inc.)] |
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| November 10 – 19, 2021
Virtual |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | University of Connecticut – Farmington, Connecticut, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Duke University – Durham, North Carolina, United States |
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