Mesenchymal Cell News Volume 13.46 | Nov 23 2021

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    2021-11-23 | MESCN 13.46


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.46 – 23 November, 2021
    TOP STORY

    Localized Drug Delivery Graphene Bioscaffolds for Cotransplantation of Islets and Mesenchymal Stem Cells

    Scientists developed, characterized, and tested an implantable graphene bioscaffold that eluted dexamethasone that could accommodate islets and adipose tissue–derived MSCs.
    [Science Advances]

    Full Article

    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Materials-Driven Fibronectin Assembly on Nanoscale Topography Enhances Mesenchymal Stem Cell Adhesion, Protecting Cells from Bacterial Virulence Factors and Preventing Biofilm Formation

    The authors used a poly ethyl acrylate polymer coating on titanium nanowires to spontaneously organize fibronectin and to deliver bone morphogenetic protein 2 to enhance MSC adhesion and osteospecific signaling.
    [Biomaterials]

    Abstract

    Extracellular Vesicles Derived from Hypoxia-Preconditioned Olfactory Mucosa Mesenchymal Stem Cells Enhance Angiogenesis via miR-612

    Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism.
    [Journal of Nanobiotechnology]

    Full Article

    Nerve Growth Factor Promotes Lysyl Oxidase-Dependent Chondrosarcoma Cell Metastasis by Suppressing miR-149-5p Synthesis

    Researchers reported that nerve growth factor (NGF) facilitated lysyl oxidase-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhanced lung metastasis in a mouse model of chondrosarcoma.
    [Cell Death & Disease]

    Full Article

    The Sensitivity of Magnetic Particle Imaging and Fluorine-19 Magnetic Resonance Imaging for Cell Tracking

    Scientists assessed the cellular sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for the detection of MSCs and breast cancer cells.
    [Scientific Reports]

    Full Article

    Generation of Two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic Differentiation

    Investigators developed two mesenchymal progenitor cell (MPC) lines, MPC1 and MPC2, generated from bone marrow of male C57BL/6 mice. Both MPC1 and MPC2 cells were capable of osteogenic, adipogenic, and chondrogenic differentiation.
    [Scientific Reports]

    Full Article

    Spatiotemporal Regulation of Endogenous MSCs Using a Functional Injectable Hydrogel System for Cartilage Regeneration

    Researchers developed a hydrogel system that could release first stromal cell-derived factor-1 and then kartogenin in a unique sequential drug release mode, which spatiotemporally promoted the recruitment and chondrogenic differentiation of MSCs.
    [NPG Asia Materials]

    Full Article

    Runx3 Is Required for Oncogenic Myc Upregulation in p53-Deficient Osteosarcoma

    The authors detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression.
    [Oncogene]

    Abstract

    Combination of Human Endothelial Colony-Forming Cells and Mesenchymal Stromal Cells Exert Neuroprotective Effects in the Growth-Restricted Newborn

    Scientists examined whether pure fetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta were neuroprotective through modulating neuroinflammation and supporting the brain vasculature.
    [NPJ Regenerative Medicine]

    Full Article

    3D Spheroids of Human Placenta-Derived Mesenchymal Stem Cells Attenuate Spinal Cord Injury in Mice

    Investigators found that 3D human placenta-derived MSCs demonstrated a significant increase in the secretion of anti-inflammatory factors and trophic factors like VEGF, PDGF, FGF via QPCR and Bio-Plex assays.
    [Cell Death & Disease]

    Full Article

    Caspase-3/NLRP3 Signaling in the Mesenchymal Stromal Niche Regulates Myeloid-Biased Hematopoiesis

    Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.
    [Stem Cell Research & Therapy]

    Full Article

    Biliary Atresia-Specific Deciduous Pulp Stem Cells Feature Biliary Deficiency

    Researchers isolated human exfoliated deciduous teeth, namely biliary atresia-SHED, using a standard colony-forming unit fibroblast method and compared characteristics as MSCs to healthy donor-derived control SHED.
    [Stem Cell Research & Therapy]

    Full Article

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Mesenchymal Stem Cell-Derived Exosome: A Tumor Regulator and Carrier for Targeted Tumor Therapy

    The authors review the current knowledge regarding the involvement of exosomes secreted by MSCs in tumor progression and their potential as drug delivery systems in targeted therapy.
    [Cancer Letters]

    Full Article

    Pharmaceutical Therapeutics for Articular Regeneration and Restoration: State-of-the-Art Technology for Screening Small Molecular Drugs

    Scientists present current achievements in the development of small molecular drugs for cartilage regeneration, particularly in the fields of chondrocyte generation and reversion of chondrocyte degenerative phenotypes.
    [Cellular and Molecular Life Sciences]

    Full Article

    Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

    MSC transplantation therapy, which can trigger neuronal regeneration and repair, has been considered a significant advance in the treatment of ischemic stroke.
    [Stem Cells International]

    Full Article

    INDUSTRY AND POLICY NEWS

    Business Partnership for Development and Commercialization of Medical Device Implant Utilizing MSC2 for the Regeneration of Esophageal Tissue in Humans

    SanBio Company Limited announced that it entered into a business partnership agreement with D&P Bioinnovations, Inc. regarding the development and commercialization of a medical device implant utilizing the company’s regenerative medicine MSC2 for the regeneration of esophageal tissue in humans.
    [SanBio Company Limited]

    Press Release

    FEATURED EVENT

    Stem Cell Society Singapore Symposium 2021

    December 8 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine

    Stanford University – Palo Alto, California, United States

    Research Assistant – Translational Research on the Leukemia Niche

    Karolinska Institutet – Flemingsberg, Sweden

    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

    Postdoctoral Fellowship – Musculoskeletal Tissue Injury

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Research Fellow – Tumor Microenvironment

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    > See All Jobs

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