| Vol. 13.46 – 23 November, 2021 |
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| Scientists developed, characterized, and tested an implantable graphene bioscaffold that eluted dexamethasone that could accommodate islets and adipose tissue–derived MSCs. [Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used a poly ethyl acrylate polymer coating on titanium nanowires to spontaneously organize fibronectin and to deliver bone morphogenetic protein 2 to enhance MSC adhesion and osteospecific signaling. [Biomaterials] |
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| Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism. [Journal of Nanobiotechnology] |
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| Researchers reported that nerve growth factor (NGF) facilitated lysyl oxidase-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhanced lung metastasis in a mouse model of chondrosarcoma. [Cell Death & Disease] |
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| Scientists assessed the cellular sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for the detection of MSCs and breast cancer cells. [Scientific Reports] |
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| Investigators developed two mesenchymal progenitor cell (MPC) lines, MPC1 and MPC2, generated from bone marrow of male C57BL/6 mice. Both MPC1 and MPC2 cells were capable of osteogenic, adipogenic, and chondrogenic differentiation. [Scientific Reports] |
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| Researchers developed a hydrogel system that could release first stromal cell-derived factor-1 and then kartogenin in a unique sequential drug release mode, which spatiotemporally promoted the recruitment and chondrogenic differentiation of MSCs. [NPG Asia Materials] |
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| The authors detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression. [Oncogene] |
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| Scientists examined whether pure fetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta were neuroprotective through modulating neuroinflammation and supporting the brain vasculature. [NPJ Regenerative Medicine] |
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| Investigators found that 3D human placenta-derived MSCs demonstrated a significant increase in the secretion of anti-inflammatory factors and trophic factors like VEGF, PDGF, FGF via QPCR and Bio-Plex assays. [Cell Death & Disease] |
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| Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo. [Stem Cell Research & Therapy] |
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| Researchers isolated human exfoliated deciduous teeth, namely biliary atresia-SHED, using a standard colony-forming unit fibroblast method and compared characteristics as MSCs to healthy donor-derived control SHED. [Stem Cell Research & Therapy] |
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| The authors review the current knowledge regarding the involvement of exosomes secreted by MSCs in tumor progression and their potential as drug delivery systems in targeted therapy. [Cancer Letters] |
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| Scientists present current achievements in the development of small molecular drugs for cartilage regeneration, particularly in the fields of chondrocyte generation and reversion of chondrocyte degenerative phenotypes. [Cellular and Molecular Life Sciences] |
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| MSC transplantation therapy, which can trigger neuronal regeneration and repair, has been considered a significant advance in the treatment of ischemic stroke. [Stem Cells International] |
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| SanBio Company Limited announced that it entered into a business partnership agreement with D&P Bioinnovations, Inc. regarding the development and commercialization of a medical device implant utilizing the company’s regenerative medicine MSC2 for the regeneration of esophageal tissue in humans. [SanBio Company Limited] |
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| December 8 – 9, 2021 Virtual |
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| Stanford University – Palo Alto, California, United States |
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| Karolinska Institutet – Flemingsberg, Sweden |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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