Mesenchymal Cell News Volume 13.47 | Nov 30 2021

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    2021-11-30 | MESCN 13.47


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.47 – 30 November, 2021
    TOP STORY

    Cartilaginous Extracellular Matrix Enriched with Human Gingival Mesenchymal Stem Cells Derived “Matrix Bound Extracellular Vesicles” Enabled Functional Reconstruction of Tracheal Defect

    Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (cECM), which were further preserved in acellular cECM following mild, short-period decellularization.
    [Advanced Science]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    Dexamethasone-Mediated Inhibition of Notch Signaling Blocks the Interaction of Leukemia and Mesenchymal Stromal Cells

    Scientists investigated leukemia-bone marrow (BM) niche-associated signaling and identified signaling cascades supporting the interaction of leukemic cells and BM MSCs. They demonstrated functional differences between MSCs originating from leukemic and healthy donors.
    [British Journal of Haematology]

    Full Article

    Bone Morphogenetic Protein 9 Enhances Osteogenic and Angiogenic Responses of Human Amniotic Mesenchymal Stem Cells Cocultured with Umbilical Vein Endothelial Cells through the PI3K/AKT/M-TOR Signaling Pathway

    The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic MSCs cocultured with human umbilical vein endothelial cells and determined the possible underlying molecular mechanism.
    [Aging]

    Full Article

    Increased Proliferation and Differentiation Capacity of Placenta-Derived Mesenchymal Stem Cells from Women of Median Maternal Age Correlates with Telomere Shortening

    Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties.
    [Aging]

    Full Article

    Patient-Derived Xenografts and In Vitro Model Show Rationale for Imatinib Mesylate Repurposing in HEY1-NCoA2-Driven Mesenchymal Chondrosarcoma

    Scientists presented the development of two independent in vitro and in vivo models of HEY1-NCoA2-driven mesenchymal chondrosarcoma and their application in a drug repurposing strategy.
    [Laboratory Investigation]

    Abstract

    Dual Electrochemical Sensing of Spiked Virus and SARS-CoV-2 Using Natural Bed-Receptor (MV-gal1)

    Investigators introduced a natural bed-receptor surface as Microparticle Vesicle-Galactins1 (MV-gal1) with the ability of glycan binding to screen every spiked virus.
    [Scientific Reports]

    Full Article

    JAZF1, YWHAE, and BCOR Gene Translocation in Primary Extrauterine Low-Grade and High-Grade Endometrial Stromal Sarcomas

    In extrauterine low-grade endometrial stromal sarcoma (LG-ESS), the positive rate of JAZF1 gene rearrangement was significantly lower than in uterine LG-ESS, limiting the value of JAZF1 gene translocation for diagnosis.
    [Histopathology]

    AbstractGraphical Abstract

    Human Adipose-Derived Stromal/Stem Cells Expressing Doublecortin Improve Cartilage Repair in Rabbits and Monkeys

    The authors expressed doublecortin (DCX) in human adipose-derived stromal/stem cells (hASCs) and engineered hASCs into cartilage tissues. They found that DCX expression in hASCs increased expression of growth differentiation factor 5 and matrilin 2 in the engineered cartilage tissues.
    [NPJ Regenerative Medicine]

    Full Article

    Comprehensive Analysis of Human Chorionic Membrane Extracts Regulating Mesenchymal Stem Cells during Osteogenesis

    Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts.
    [Cell Proliferation]

    Full Article

    Sevoflurane Preconditioning Promotes Mesenchymal Stem Cells to Relieve Myocardial Ischemia/Reperfusion Injury via TRPC6-Induced Angiogenesis

    Scientists investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial ischemia/reperfusion injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis.
    [Stem Cell Research & Therapy]

    Full Article

    Exosomes Derived from miR-129-5p Modified Bone Marrow Mesenchymal Stem Cells Represses Ventricular Remolding of Mice with Myocardial Infarction

    Investigators found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma

    Researchers investigated the potential antifibrotic and anti-inflammatory effects of exosomes derived from human umbilical cord MSCs in a bleomycin-induced mouse model of scleroderma.
    [Tissue Engineering and Regenerative Medicine]

    Full Article

    The Effects of Altered BMP4 Signaling in First Branchial-Arch-Derived Murine Embryonic Orofacial Tissues

    By compounding Pax2-Cre and R26R-mTmG mice, the authors found a specific expression pattern of Pax2+ cells that marked the first branchial arch (BA1)’s mesenchymal cells and the BA1-derivatives.
    [International Journal of Oral Science]

    Full Article

    Explore scientific events this December with the Science Events Calendar.
    REVIEWS

    Current Progress of Rehabilitative Strategies in Stem Cell Therapy for Spinal Cord Injury: A Review

    Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury.
    [NPJ Regenerative Medicine]

    Full Article

    Role of EZH2 in Bone Marrow Mesenchymal Stem Cells and Immune-Cancer Interactions

    The authors review the role of enhancer of zeste homology 2 (EZH2) in regulating bone marrow MSC differentiation and the immune cell function in tumor microenvironment, summarize all types of existing EZH2 inhibitors and the main clinical trials, and propose relevant ideas for potential clinical applications.
    [Critical Reviews in Oncology/Hematology]

    AbstractGraphical Abstract

    The Hepatic Stellate Cells (HSTCs) and Adipose-Derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

    Investigators suggest that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represent a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Aadi Bioscience Announces FDA Approval of Its First Product FYARRO for Patients with Locally Advanced Unresectable or Metastatic Malignant Perivascular Epithelioid Cell Tumor (PEComa)

    Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.
    [Aadi Bioscience, Inc.]

    Press Release

    European Commission Approves KEYTRUDA® (Pembrolizumab) plus LENVIMA® (Lenvatinib) for Patients with Certain Types of Endometrial Carcinoma

    Merck and Eisai announced that the European Commission has approved the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA for the treatment of advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum‑containing therapy.
    [Merck]

    Press Release

    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    February 5 – 9, 2022
    Maui, Hawaii, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Professor – Burn Care and Regenerative Medicine

    CHUM Research Center – Montreal, Quebec, Canada

    Faculty Positions – Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine

    Stanford University – Palo Alto, California, United States

    Research Assistant – Translational Research on the Leukemia Niche

    Karolinska Institutet – Flemingsberg, Sweden

    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

    Postdoctoral Fellowship – Musculoskeletal Tissue Injury

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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