| Vol. 13.47 – 30 November, 2021 |
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| Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (cECM), which were further preserved in acellular cECM following mild, short-period decellularization. [Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated leukemia-bone marrow (BM) niche-associated signaling and identified signaling cascades supporting the interaction of leukemic cells and BM MSCs. They demonstrated functional differences between MSCs originating from leukemic and healthy donors. [British Journal of Haematology] |
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| The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic MSCs cocultured with human umbilical vein endothelial cells and determined the possible underlying molecular mechanism. [Aging] |
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| Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties. [Aging] |
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| Scientists presented the development of two independent in vitro and in vivo models of HEY1-NCoA2-driven mesenchymal chondrosarcoma and their application in a drug repurposing strategy. [Laboratory Investigation] |
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| Investigators introduced a natural bed-receptor surface as Microparticle Vesicle-Galactins1 (MV-gal1) with the ability of glycan binding to screen every spiked virus. [Scientific Reports] |
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| In extrauterine low-grade endometrial stromal sarcoma (LG-ESS), the positive rate of JAZF1 gene rearrangement was significantly lower than in uterine LG-ESS, limiting the value of JAZF1 gene translocation for diagnosis. [Histopathology] |
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| The authors expressed doublecortin (DCX) in human adipose-derived stromal/stem cells (hASCs) and engineered hASCs into cartilage tissues. They found that DCX expression in hASCs increased expression of growth differentiation factor 5 and matrilin 2 in the engineered cartilage tissues. [NPJ Regenerative Medicine] |
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| Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts. [Cell Proliferation] |
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| Scientists investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial ischemia/reperfusion injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis. [Stem Cell Research & Therapy] |
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| Investigators found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines. [Journal of Tissue Engineering and Regenerative Medicine] |
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| Researchers investigated the potential antifibrotic and anti-inflammatory effects of exosomes derived from human umbilical cord MSCs in a bleomycin-induced mouse model of scleroderma. [Tissue Engineering and Regenerative Medicine] |
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| By compounding Pax2-Cre and R26R-mTmG mice, the authors found a specific expression pattern of Pax2+ cells that marked the first branchial arch (BA1)’s mesenchymal cells and the BA1-derivatives. [International Journal of Oral Science] |
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| Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury. [NPJ Regenerative Medicine] |
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| The authors review the role of enhancer of zeste homology 2 (EZH2) in regulating bone marrow MSC differentiation and the immune cell function in tumor microenvironment, summarize all types of existing EZH2 inhibitors and the main clinical trials, and propose relevant ideas for potential clinical applications. [Critical Reviews in Oncology/Hematology] |
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| Investigators suggest that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represent a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity. [Stem Cell Reviews and Reports] |
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| Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO™ for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa. [Aadi Bioscience, Inc.] |
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| Merck and Eisai announced that the European Commission has approved the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA for the treatment of advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum‑containing therapy. [Merck] |
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| February 5 – 9, 2022 Maui, Hawaii, United States |
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| CHUM Research Center – Montreal, Quebec, Canada |
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| Stanford University – Palo Alto, California, United States |
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| Karolinska Institutet – Flemingsberg, Sweden |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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