Mesenchymal Cell News Volume 13.48 | Dec 7 2021

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    2021-12-07 | MESCN 13.48


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.48 – 7 December, 2021
    TOP STORY

    Human Platelet Lysate (hPL) Alters the Lineage Commitment and Paracrine Functions of Human Mesenchymal Stem Cells via Mitochondrial Metabolism

    Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.
    [Applied Materials Today]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Role of PD-L1 in Licensing Immunoregulatory Function of Dental Pulp Mesenchymal Stem Cells

    Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs.
    [Stem Cell Research & Therapy]

    Full Article

    22-kD Growth Hormone-Induced Nuclear GHR/STAT5/CyclinD1 Signaling Pathway Plays an Important Role in Promoting Mesenchymal Stem Cell Proliferation

    A series of experiments were performed to systematically investigate the cellular behavior of growth hormone (GH)/GH receptor (GHR) in MSCs, and the results showed that GH/GHR not only internalized into the cytoplasm, but also transported into the cell nuclei of MSCs.
    [Biofactors]

    Abstract

    Adipose Derived Mesenchymal Stem Cell Secretome Formulation as a Biotherapeutic to Inhibit Growth of Drug Resistant Triple Negative Breast Cancer

    Researchers developed a protocol for processing human adipose derived MSC secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro was studied using breast cancer cell lines to determine its role in suppressing triple negative breast cancer.
    [Scientific Reports]

    Full Article

    miR-140-3p Enhanced the Osteo/Odontogenic Differentiation of DPSCs via Inhibiting KMT5B under Hypoxia Condition

    The authors revealed the role and mechanism of miR-140-3p for regulating osteo/dentinogenic differentiation of dental pulp stem cells (DPSCs) under hypoxia, and discovered that miR-140-3p and lysine methyltransferase 5B (KMT5B) might be important targets for DPSC-mediated tooth or bone tissue regeneration.
    [International Journal of Oral Science]

    Full Article

    Angle-Ply Scaffold Supports Annulus Fibrosus Matrix Expression and Remodeling by Mesenchymal Stromal and Annulus Fibrosus Cells

    A collagen-based, angle-ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling.
    [Journal of Biomedical Materials Research Part B-Applied Biomaterials]

    Abstract

    Mesenchymal Stromal Cells Mitigate Liver Damage after Extended Resection in the Pig by Modulating Thrombospondin-1/TGF-β

    Investigators suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration.
    [NPJ Regenerative Medicine]

    Full Article

    Exosomes Isolated from Melatonin-Stimulated Mesenchymal Stem Cells Improve Kidney Function by Regulating Inflammation and Fibrosis in a Chronic Kidney Disease Mouse Model

    Researchers investigated the therapeutic effects of exosomes secreted by melatonin-stimulated MSCs on the functional recovery of the kidney in a chronic kidney disease mouse model.
    [Journal of Tissue Engineering]

    Full Article

    Mesenchymal Stem Cell Therapy in Decompensated Liver Cirrhosis: A Long-Term Follow-Up Analysis of the Randomized Controlled Clinical Trial

    Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.
    [Hepatology International]

    Full ArticleGraphical Abstract

    Identification of Alpha-Enolase as a Potential Immunogenic Molecule during Allogeneic Transplantation of Human Adipose-Derived Mesenchymal Stromal Cells

    The allorejection of MSCs indicates that they are not fully immune-privileged. Scientists investigated the immunogenicity of human adipose-derived MSCs and identified potential immunogenic molecules.
    [Cytotherapy]

    Abstract

    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    Recent Strategies for Enhancing the Therapeutic Efficacy of Stem Cells in Wound Healing

    The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.
    [Stem Cell Research & Therapy]

    Full Article

    Potential Role of Growth Factors Controlled Release in Achieving Enhanced Neuronal Trans-Differentiation from Mesenchymal Stem Cells for Neural Tissue Repair and Regeneration

    Investigators analyze the various carriers that have been employed for the release of growth factors in an orderly fashion and their constituents, along with the advantages and the limitations they pose in delivering the growth factors for facilitating the process of neuronal transdifferentiation.
    [Molecular Neurobiology]

    AbstractGraphical Abstract

    Mesenchymal Stem Cell-Based Nanoparticles and Scaffolds in Regenerative Medicine

    Scientists review MSC-based nanocomposite’s current approaches and compare their advantages and limitations for building effective regenerative medicines.
    [European Journal of Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    QSAM Biosciences Activates Clinical Sites and Opens Enrollment for Its Phase I Clinical Trial of CycloSam® for the Treatment of Bone Cancer

    QSAM Biosciences, Inc. announced the activation of its first clinical trial site and the initiation of enrollment of patients into its Phase I clinical trial evaluating CycloSam® for multiple types of bone cancer that either originated in or has metastasized to the bone.
    [QSAM Biosciences, Inc.]

    Press Release

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    JOB OPPORTUNITIES

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    Stanford University – Palo Alto, California, United States

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    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

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