| Vol. 13.48 – 7 December, 2021 |
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| Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum. [Applied Materials Today] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs. [Stem Cell Research & Therapy] |
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| A series of experiments were performed to systematically investigate the cellular behavior of growth hormone (GH)/GH receptor (GHR) in MSCs, and the results showed that GH/GHR not only internalized into the cytoplasm, but also transported into the cell nuclei of MSCs. [Biofactors] |
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| Researchers developed a protocol for processing human adipose derived MSC secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro was studied using breast cancer cell lines to determine its role in suppressing triple negative breast cancer. [Scientific Reports] |
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| The authors revealed the role and mechanism of miR-140-3p for regulating osteo/dentinogenic differentiation of dental pulp stem cells (DPSCs) under hypoxia, and discovered that miR-140-3p and lysine methyltransferase 5B (KMT5B) might be important targets for DPSC-mediated tooth or bone tissue regeneration. [International Journal of Oral Science] |
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| A collagen-based, angle-ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling. [Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| Investigators suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration. [NPJ Regenerative Medicine] |
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| Researchers investigated the therapeutic effects of exosomes secreted by melatonin-stimulated MSCs on the functional recovery of the kidney in a chronic kidney disease mouse model. [Journal of Tissue Engineering] |
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| Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis. [Hepatology International] |
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| The allorejection of MSCs indicates that they are not fully immune-privileged. Scientists investigated the immunogenicity of human adipose-derived MSCs and identified potential immunogenic molecules. [Cytotherapy] |
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| The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation. [Stem Cell Research & Therapy] |
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| Investigators analyze the various carriers that have been employed for the release of growth factors in an orderly fashion and their constituents, along with the advantages and the limitations they pose in delivering the growth factors for facilitating the process of neuronal transdifferentiation. [Molecular Neurobiology] |
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| Scientists review MSC-based nanocomposite’s current approaches and compare their advantages and limitations for building effective regenerative medicines. [European Journal of Pharmacology] |
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| QSAM Biosciences, Inc. announced the activation of its first clinical trial site and the initiation of enrollment of patients into its Phase I clinical trial evaluating CycloSam® for multiple types of bone cancer that either originated in or has metastasized to the bone. [QSAM Biosciences, Inc.] |
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| January 9 – 12, 2022 Portland, Oregon, United States |
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| University of Calgary – Calgary, Alberta, Canada |
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| Centre de recherche du CHUM – Montreal, Quebec, Canada |
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| Stanford University – Palo Alto, California, United States |
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| Karolinska Institutet – Flemingsberg, Sweden |
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