Mesenchymal Cell News Volume 14.00 | Jan 4 2022

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    2022-01-04 | MESCN 14.00


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.00 – 4 January, 2022
    TOP STORY

    Engineered Mesenchymal Stem Cells as a Biotherapy Platform for Targeted Photodynamic Immunotherapy of Breast Cancer

    An engineered stem cell-based biotherapy platform incorporating immune gene plasmid IL12 and photosensitizer methylene blue was developed to realize tumor-homing delivery of therapeutic agents and photo-immunotherapy efficacy enhancement.
    [Advanced Healthcare Materials]

    Abstract

    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Overlapping Morphological, Immunohistochemical and Genetic Features of Superficial CD34-Positive Fibroblastic Tumor and PRDM10-Rearranged Soft Tissue Tumor

    Scientists investigated a series of superficial CD34-positive fibroblastic tumors or PRDM10-rearranged tumors and potential mimics with regard to morphological, genetic, and immunohistochemical features.
    [Modern Pathology]

    Abstract

    TGF-β1 in Seminal Plasma Promotes Endometrial Mesenchymal Stem Cell Growth via p42/44 and Akt Pathway in Patients with or without Endometriosis

    The authors evaluated the effect of seminal plasma on growth of endometrial MSCs from women with endometriosis and women without endometriosis.
    [Reproductive Sciences]

    Abstract

    Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate

    Researchers reported a novel strategy to generate highly pure mouse bone marrow MSCs using liposomal clodronate.
    [Tissue Engineering and Regenerative Medicine]

    Full Article

    Sodium Alginate Microencapsulation of Human Mesenchymal Stromal Cells Modulates Paracrine Signaling Response and Enhances Efficacy for Treatment of Established Osteoarthritis

    Scientists assessed the effects of sodium alginate microencapsulation on human MSC secretion of immunomodulatory cytokines in an osteoarthritis (OA) microenvironment and therapeutic efficacy in treating established OA.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    M6A Regulator-Mediated Methylation Modification Patterns and Tumor Immune Microenvironment in Sarcoma

    The authors evaluated the N6-methyladenosine (m6A) regulator expression patterns in patients with sarcoma based on known 23 m6A regulators. Different m6A regulator expression patterns were analyzed using gene set variation analysis and a single-sample gene set enrichment analysis algorithm.
    [Aging]

    Full Article

    Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

    Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.
    [Brain Research Bulletin]

    Abstract

    Overexpression of NMNAT3 Improves Mitochondrial Function and Enhances Anti-Oxidative Stress of Bone Marrow Mesenchymal Stem Cells via the NAD+-Sirt3 Pathway

    Researchers confirmed that overexpression of nicotinamide mononucleotide adenylyl transferase 3 (NMNAT3) improved mitochondrial function and resistance to stress-induced apoptosis in bone marrow MSCs.
    [Bioscience Reports]

    Abstract

    Allogeneic Adipose-Derived Mesenchymal Stromal Cell Transplantation for Refractory Lupus Nephritis: Results of a Phase I Clinical Trial

    In a Phase I trial, nine biopsy-proven lupus nephritis patients refractory to standard treatments underwent systemic infusion of 2×106 allogeneic adipose-derived MSCs/kg and were followed for 12 months post-intervention.
    [Current Research in Translational Medicine]

    Abstract

    Guide to everything you need to know about cell separation.
    REVIEWS

    The Role of Mesenchymal Stem Cells in the Occurrence, Development, and Therapy of Hepatocellular Carcinoma

    Investigators analyzed the role of MSCs in the tumor microenvironment and summarized the relationship between MSCs and liver cancer stem cells.
    [Cancer Medicine]

    Full Article

    Dental Stem Cell-Derived Extracellular Vesicles as Promising Therapeutic Agents in the Treatment of Diseases

    The authors review the latest in vivo evidence that supports the therapeutic effects of dental stem cell-derived extracellular vesicles with mechanistic studies.
    [International Journal of Oral Science]

    Full Article

    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies Awarded an STTR Phase I Grant to Explore the Therapeutic Effects of PEG-Peptide Hydrogel-Encapsulated Hypoxic Bone Marrow Stem Cells

    BioRestorative Therapies, Inc. announced that it has been awarded a Small Business Technology Transfer (STTR) Phase I grant for $256,000 to evaluate the therapeutic effects on the company’s hypoxic cultured bone marrow derived MSCs after encapsulation with a PEG-peptide hydrogel.
    [BioRestorative Therapies, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    The Australian Society for Stem Cell Research (ASSCR) Annual Meeting

    March 9 – 11, 2022
    Melbourne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Advanced Technology Core Laboratory

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Cardiovascular Disease Modeling

    Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States

    Research Professor – Burn Care and Regenerative Medicine

    Centre de recherche du CHUM – Montreal, Quebec, Canada

    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

    Scientific Officer – Functional Genomics

    Institute of Cancer Research – London, England, United Kingdom

    > See All Jobs

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