Mesenchymal Cell News Volume 14.01 | Jan 11 2022

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    2022-01-11 | MESCN 14.01


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.01 – 11 January, 2022
    TOP STORY

    Engineering Immunomodulatory and Osteoinductive Implant Surfaces via Mussel Adhesion-Mediated Ion Coordination and Molecular Clicking

    A dual-effect coating with immobilized immunomodulatory metal ions and osteoinductive growth factors was designed via mussel adhesion-mediated ion coordination and molecular clicking strategy.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    The ERα/KDM6B Regulatory Axis Modulates Osteogenic Differentiation in Human Mesenchymal Stem Cells

    Researchers found that estrogen significantly induced the expression of lysine-specific demethylase 6B (KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of dental MSCs.
    [Bone Research]

    Full Article

    Blockade of Beta-Adrenergic Receptors Reduces Cancer Growth and Enhances the Response to Anti-CTLA4 Therapy by Modulating the Tumor Microenvironment

    Investigators showed that oral administration of propranolol delayed tumor progression of MCA205 fibrosarcoma model and MC38 colon cancer model and increased the survival rate of tumor bearing mice.
    [Oncogene]

    Full Article

    Bone Mesenchymal Stem Cell-Derived Exosomal microRNA-7-5p Inhibits Progression of Acute Myeloid Leukemia by Targeting OSBPL11

    Scientists investigated the effects of exosomes derived from bone marrow MSCs on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Methylation-Mediated Silencing of Protein Kinase C Zeta Induces Apoptosis Avoidance through ATM/CHK2 Inactivation in Dedifferentiated Chondrosarcoma

    Researchers identified genes downregulated in dedifferentiated chondrosarcoma vs. conventional chondrosarcoma due to DNA methylation using in silico analysis.
    [British Journal of Cancer]

    Abstract

    Three-Dimension Co-Culture of Hematopoietic Stem Cells and Differentiated Osteoblasts on Gallic Acid Grafted-Chitosan Scaffold as a Model of Hematopoietic Stem Cells Niche

    Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord MSCs to recapitulate the main components of hematopoietic stem cells niche.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Comparative Proteomic Analysis of Nuclear and Cytoplasmic Compartments in Human Cardiac Progenitor Cells

    Two proteins significantly upregulated in the human cardiac progenitor cell (hCPC) nuclear compartment, IL1A and IMP3, showed a parallel increase in mRNA expression in hCPCs versus human MSCs, and were studied further.
    [Scientific Reports]

    Full Article

    Mechanical Force Promotes Dimethylarginine Dimethylaminohydrolase 1-Mediated Hydrolysis of the Metabolite Asymmetric Dimethylarginine to Enhance Bone Formation

    Researchers reported that mechanical force regulated the production of the metabolite asymmetric dimethylarginine via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 expression in osteoblasts.
    [Nature Communications]

    Full Article

    Human Umbilical Cord Blood Mesenchymal Stem Cells-Derived Exosomal microRNA-503-3p Inhibits Progression of Human Endometrial Cancer Cells through Downregulating MEST

    The authors investigated the influence of human umbilical cord blood MSC-derived exosomal microRNA-503-3p on human endometrial cancer cells by mediating mesoderm-specific transcript (MEST).
    [Cancer Gene Therapy]

    Abstract

    MicroRNA-149 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells via Inhibition of AKT1-Dependent Twist1 Phosphorylation

    Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism.
    [Cell Death Discovery]

    Full Article

    Exosomes from Adipose-Derived Mesenchymal Stem Cells Alleviate Sepsis-Induced Lung Injury in Mice by Inhibiting the Secretion of IL-27 in Macrophages

    The authors investigated the mechanism of exosomes from adipose-derived MSCs in sepsis-induced acute lung injury.
    [Cell Death Discovery]

    Full Article

    The Insertion and Dysregulation of Transposable Elements in Osteosarcoma and Their Association with Patient Event-Free Survival

    By integrative analysis of RNA-seq, whole-genome sequencing, and methylation data, researchers showed aberrant transposable element (TE) activities associated with dysregulations of TEs in osteosarcoma tumors.
    [Scientific Reports]

    Full Article

    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

    Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
    [Obesity Reviews]

    Full Article

    Research Progress of the Application of Mesenchymal Stem Cells in Chronic Inflammatory Systemic Diseases

    The authors describe the research progress and clinical application of MSCs in chronic inflammatory systemic diseases and look for influencing factors and biomarkers that can predict the outcome of patients with MSC transplantation.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stromal Cell-Based Therapy for Cartilage Regeneration in Knee Osteoarthritis

    Scientists summarize how to choose, authenticate, and culture different origins of MSCs and derived exosomes.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    BioAtla Announces Clinical Collaboration with Bristol Myers Squibb to Study Mecbotamab Vedotin (BA3011) and Ozuriftamab Vedotin (BA3021) in Combination with Opdivo® (Nivolumab) for Treatment of Solid Tumors

    BioAtla, Inc. announced that it has entered into a clinical collaboration with Bristol Myers Squibb to investigate BioAtla’s two lead CAB-ADC candidates, BA3011 and BA3021, in combination with Bristol Myers Squibb’s anti-PD-1 therapy nivolumab.
    [BioAtla, Inc.]

    Press Release

    Rafael Pharmaceuticals Announces Successful Completion of Dose Escalation with No Dose-Limiting Toxicity (DLT) in First Cohort of APOLLO 613 Phase I/II Clinical Trial of CPI-613® (Devimistat) in Patients with Relapsed Clear Cell Sarcoma

    Rafael Pharmaceuticals, Inc. announced the completion of the first cohort of dose escalation with no DLT in the APOLLO 613 Phase I/II clinical trial of devimistat in combination with hydroxychloroquine in patients with relapsed clear cell sarcoma.
    [Rafael Pharmaceuticals, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
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    JOB OPPORTUNITIES

    Project Manager – Therapeutic Development Branch

    National Institute of Health – Rockville, Maryland, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Research Group Leader – Therapy Resistance

    German Cancer Research Center – Frankfurt, Germany

    Research Associate – Cardiovascular Disease Modeling

    Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States

    Research Professor – Burn Care and Regenerative Medicine

    CHUM Research Center – Montreal, Quebec, Canada

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