| Vol. 14.01 – 11 January, 2022 |
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| A dual-effect coating with immobilized immunomodulatory metal ions and osteoinductive growth factors was designed via mussel adhesion-mediated ion coordination and molecular clicking strategy. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that estrogen significantly induced the expression of lysine-specific demethylase 6B (KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of dental MSCs. [Bone Research] |
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| Investigators showed that oral administration of propranolol delayed tumor progression of MCA205 fibrosarcoma model and MC38 colon cancer model and increased the survival rate of tumor bearing mice. [Oncogene] |
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| Scientists investigated the effects of exosomes derived from bone marrow MSCs on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA. [Journal of Nanobiotechnology] |
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| Researchers identified genes downregulated in dedifferentiated chondrosarcoma vs. conventional chondrosarcoma due to DNA methylation using in silico analysis. [British Journal of Cancer] |
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| Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord MSCs to recapitulate the main components of hematopoietic stem cells niche. [Stem Cell Reviews and Reports] |
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| Two proteins significantly upregulated in the human cardiac progenitor cell (hCPC) nuclear compartment, IL1A and IMP3, showed a parallel increase in mRNA expression in hCPCs versus human MSCs, and were studied further. [Scientific Reports] |
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| Researchers reported that mechanical force regulated the production of the metabolite asymmetric dimethylarginine via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 expression in osteoblasts. [Nature Communications] |
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| The authors investigated the influence of human umbilical cord blood MSC-derived exosomal microRNA-503-3p on human endometrial cancer cells by mediating mesoderm-specific transcript (MEST). [Cancer Gene Therapy] |
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| Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism. [Cell Death Discovery] |
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| The authors investigated the mechanism of exosomes from adipose-derived MSCs in sepsis-induced acute lung injury. [Cell Death Discovery] |
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| By integrative analysis of RNA-seq, whole-genome sequencing, and methylation data, researchers showed aberrant transposable element (TE) activities associated with dysregulations of TEs in osteosarcoma tumors. [Scientific Reports] |
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| Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use. [Obesity Reviews] |
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| The authors describe the research progress and clinical application of MSCs in chronic inflammatory systemic diseases and look for influencing factors and biomarkers that can predict the outcome of patients with MSC transplantation. [Stem Cell Research & Therapy] |
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| Scientists summarize how to choose, authenticate, and culture different origins of MSCs and derived exosomes. [Stem Cell Research & Therapy] |
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| BioAtla, Inc. announced that it has entered into a clinical collaboration with Bristol Myers Squibb to investigate BioAtla’s two lead CAB-ADC candidates, BA3011 and BA3021, in combination with Bristol Myers Squibb’s anti-PD-1 therapy nivolumab. [BioAtla, Inc.] |
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| Rafael Pharmaceuticals, Inc. announced the completion of the first cohort of dose escalation with no DLT in the APOLLO 613 Phase I/II clinical trial of devimistat in combination with hydroxychloroquine in patients with relapsed clear cell sarcoma. [Rafael Pharmaceuticals, Inc. (Globe Newswire, Inc.)] |
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| National Institute of Health – Rockville, Maryland, United States |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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| German Cancer Research Center – Frankfurt, Germany |
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| Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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| CHUM Research Center – Montreal, Quebec, Canada |
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