 | | Vol. 14.03 – 25 January, 2022 |
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| Researchers generated models of sarcomas bearing kinase fusions and assessed their response to molecularly targeted therapy. Immortalized, untransformed human MSCs, a putative cell-of-origin of sarcomas, were modified using CRISPR-Cas9 to harbor a RET chromosomal translocation.
[Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Antiphospholipid autoantibodies increased human endometrial stromal cell decidualization, senescence, and inflammation. The decidualization and inflammatory responses were partially mediated by toll-like receptor 4 (TLR4) and p38 MAP kinase.
[Arthritis & Rheumatology] |
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| Scientists showed that the signaling protein WNT3A counteracted the induction of paracrine senescence in cultured human adult MSCs.
[Cellular and Molecular Life Sciences] |
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| In order to develop new 3D cell culture systems for articular cartilage regeneration, concentrated poly(styrene sulfonate sodium salt) brush-modified cellulose nanofibers were employed as building blocks for the self-assembly of human MSCs.
[Journal of Materials Chemistry B] |
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| The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.
[Stem Cell Research & Therapy] |
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| Researchers demonstrated the capacity of licensing hydrogel-encapsulated human MSCs to limit the in vivo progression of inflammatory bowel diseases.
[European Journal of Pharmaceutics and Biopharmaceutics] |
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| Scientists investigated the physiological mechanisms by which extracellular vesicle-encapsulated miR-181a–2–3p derived from MSCs might mediate oxidative stress in Parkinson’s disease
[Cell Death Discovery] |
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| The authors investigated the therapeutic effect of miR-223 in exosomes secreted by bone marrow MSCs on immune response in the progression of rheumatoid arthritis.
[Molecular Immunology] |
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| The effect of 3D printed polycaprolactone/polypyrrole conductive scaffolds on differentiation of human olfactory ecto-MSCs into functional Schwann cell-like phenotypes was investigated.
[Journal of Biomedical Materials Research Part A] |
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| Investigators examined the early effect of photobiomodulation (PBM) in pericytes from experimentally injured pulp tissue. In vitro, PBM induced VEGF upregulation, improved dental pulp cells proliferation, and migration, and favored their mineralization potential.
[Journal of Cellular Physiology] |
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| The authors investigated the repair of thin endometrium in rats using the umbilical cord mesenchymal stem cells and the mechanisms involved.
[Scientific Reports] |
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| Researchers assessed the cell fate of PRX1+ cells during molar development and periodontal ligament (PDL) formation in mice and performed single-cell RNA sequencing analysis to study the distribution of PRX1+ cells in PDL cells.
[International Journal of Oral Science] |
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| The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs.
[Cellular and Molecular Life Sciences] |
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| Scientists overview recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.
[Stem Cell Research & Therapy] |
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| Lyell Immunopharma, Inc. announced that the US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1.
[Lyell Immunopharma, Inc.] |
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| 29 – 31 March, 2022
Boston, Massachusetts, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | National Institute of Health – Rockville, Maryland, United States |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
