| Vol. 14.04 – 1 February, 2022 |
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| The authors developed an activated near-infrared II fluorescent nanoparticle consisting of lanthanide-based down-conversion nanoparticles and IR786s for cell labeling and real-time tracking of adipose-derived MSC viability in vivo. [ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells. [Nature Communications] |
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| USP26 stabilized β-catenin to promote the osteogenic activity of MSCs and impaired the osteoclastic differentiation of bone myelomonocytes by stabilizing inhibitors of NF-κBα. [Cell Death & Differentiation] |
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| Administration of human umbilical cord MSC exosomes promoted imatinib-induced cell apoptosis through miR-145a-5p/USP6. [Cell Death & Disease] |
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| Researchers characterized the functionality of autologous MSCs for use as an idiopathic pulmonary fibrosis therapy and presented an attempt to determine whether the disease occurring in the lungs was associated with an alterated immune system. [Stem Cell Research & Therapy] |
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| The authors described a ten day long adipogenesis model using high content analysis readouts for adipocyte number, size, and lipid content on primary human MSC sensitive enough to compare bisphenol A derivatives quantitatively in a robust and high throughput manner. [Food and Chemical Toxicology] |
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| Synovium-derived MSCs (SMSCs) were isolated from synovium specimens of patients undergoing temporomandibular joint surgery. Chondrogenic differentiation potential of SMSCs was evaluated in vitro in the control, IL-1β stimulation, and IL-1β stimulation with histone deacetylase inhibitors groups. [Bone & Joint Journal] |
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| Investigators loaded umbilical cord-derived MSCs with oncolytic adenoviruses expressing decorin or without foreign genes to treat breast cancer lung metastasis. [Molecular Therapy Oncolytics] |
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| To reveal why young individuals have higher regenerative capacity than the elderly, the authors constructed metabolic profiles for primate juvenile and aged tissues, as well as young and aged human stem cells. [Cell Discovery] |
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| Scientists showed that the combination of MSC exosomes and hyaluronic acid administered at a clinically acceptable frequency of three weekly intra-articular injections could promote functional cartilage and subchondral bone repair. [American Journal of Sports Medicine] |
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| Researchers described the use of an MSC-based delivery system for the secretion of a Zinc fingers protein in transgenic mouse models and young rhesus monkeys. [Frontiers in Molecular Neuroscience] |
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| Scientists identified the efficacy and safety of MSCs for multidrug-resistant-graft-versus-host disease after haploidentical donor hematopoietic stem cell transplantation. [Therapeutic Advances in Hematology] |
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| In recent years, a growing line of research has shown the participation of exosomal microRNAs in the pathophysiological processes of diabetic nephropathy (DN), which may provide effective therapeutic and biomarker tools for DN treatment. [Stem Cell Research & Therapy] |
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| The authors provide an overview of the properties and potentials of MSCs in cancer therapy as well as the application of MSC-derived exosomes in cancer therapy. [Cancer Gene Therapy] |
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| Leonhardt Ventures LLC announced that it has begun an active research program to combine its patent-pending klotho expression bioelectric stimulation technologies with newly acquired klotho expressing MSC technology. [Leonhardt Ventures (Globe Newswire, Inc.)] |
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| March 13 – 18, 2022 Ventura, California, United States |
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| Stanford University – Stanford, California, United States |
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| Nanyang Technological University – Singapore, Singapore |
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| University of Texas Medical Branch – Galveston, Texas, United States |
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| National University of Ireland Galway – Galway, Ireland |
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| Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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