Mesenchymal Cell News Volume 14.04 | Feb 1 2022

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    2022-02-01 | MESCN 14.04


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.04 – 1 February, 2022
    TOP STORY

    Tracking Cell Viability for Adipose-Derived Mesenchymal Stem Cell-Based Therapy by Quantitative Fluorescence Imaging in the Second Near-Infrared Window

    The authors developed an activated near-infrared II fluorescent nanoparticle consisting of lanthanide-based down-conversion nanoparticles and IR786s for cell labeling and real-time tracking of adipose-derived MSC viability in vivo.
    [ACS Nano]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal Stromal Cell-Derived Septoclasts Resorb Cartilage during Developmental Ossification and Fracture Healing

    Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.
    [Nature Communications]

    Full Article

    The Osteoprotective Role of USP26 in Coordinating Bone Formation and Resorption

    USP26 stabilized β-catenin to promote the osteogenic activity of MSCs and impaired the osteoclastic differentiation of bone myelomonocytes by stabilizing inhibitors of NF-κBα.
    [Cell Death & Differentiation]

    Full Article

    HucMSC Exosomes Promoted Imatinib-Induced Apoptosis in K562-R Cells via a miR-145a-5p/USP6/GLS1 Axis

    Administration of human umbilical cord MSC exosomes promoted imatinib-induced cell apoptosis through miR-145a-5p/USP6.
    [Cell Death & Disease]

    Full Article

    Normal Ex Vivo Mesenchymal Stem Cell Function Combined with Abnormal Immune Profiles Sets the Stage for Informative Cell Therapy Trials in Idiopathic Pulmonary Fibrosis Patients

    Researchers characterized the functionality of autologous MSCs for use as an idiopathic pulmonary fibrosis therapy and presented an attempt to determine whether the disease occurring in the lungs was associated with an alterated immune system.
    [Stem Cell Research & Therapy]

    Full Article

    High Throughput Screening of Bisphenols and Their Mixtures under Conditions of Low-Intensity Adipogenesis of Human Mesenchymal Stem Cells (hMSCs)

    The authors described a ten day long adipogenesis model using high content analysis readouts for adipocyte number, size, and lipid content on primary human MSC sensitive enough to compare bisphenol A derivatives quantitatively in a robust and high throughput manner.
    [Food and Chemical Toxicology]

    Full Article

    Histone Deacetylase Inhibitors Attenuated Interleukin-1β-Induced Chondrogenesis Inhibition in Synovium-Derived Mesenchymal Stem Cells of the Temporomandibular Joint

    Synovium-derived MSCs (SMSCs) were isolated from synovium specimens of patients undergoing temporomandibular joint surgery. Chondrogenic differentiation potential of SMSCs was evaluated in vitro in the control, IL-1β stimulation, and IL-1β stimulation with histone deacetylase inhibitors groups.
    [Bone & Joint Journal]

    Full Article

    Therapeutic Effects of Mesenchymal Stem Cells Loaded with Oncolytic Adenovirus Carrying Decorin on a Breast Cancer Lung Metastatic Mouse Model

    Investigators loaded umbilical cord-derived MSCs with oncolytic adenoviruses expressing decorin or without foreign genes to treat breast cancer lung metastasis.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Cross-Species Metabolomic Analysis Identifies Uridine as a Potent Regeneration Promoting Factor

    To reveal why young individuals have higher regenerative capacity than the elderly, the authors constructed metabolic profiles for primate juvenile and aged tissues, as well as young and aged human stem cells.
    [Cell Discovery]

    Full Article

    Mesenchymal Stem Cell Exosomes Promote Functional Osteochondral Repair in a Clinically Relevant Porcine Model

    Scientists showed that the combination of MSC exosomes and hyaluronic acid administered at a clinically acceptable frequency of three weekly intra-articular injections could promote functional cartilage and subchondral bone repair.
    [American Journal of Sports Medicine]

    Abstract

    An In Vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-Clinical Animal Models

    Researchers described the use of an MSC-based delivery system for the secretion of a Zinc fingers protein in transgenic mouse models and young rhesus monkeys.
    [Frontiers in Molecular Neuroscience]

    Full Article

    Efficacy and Safety of Mesenchymal Stem Cells Treatment for Multidrug-Resistant Graft-versus-Host Disease after Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation

    Scientists identified the efficacy and safety of MSCs for multidrug-resistant-graft-versus-host disease after haploidentical donor hematopoietic stem cell transplantation.
    [Therapeutic Advances in Hematology]

    Full Article

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    REVIEWS

    Stem Cell-Derived and Circulating Exosomal MicroRNAs as New Potential Tools for Diabetic Nephropathy Management

    In recent years, a growing line of research has shown the participation of exosomal microRNAs in the pathophysiological processes of diabetic nephropathy (DN), which may provide effective therapeutic and biomarker tools for DN treatment.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stem Cell (MSC)-Derived Exosomes as Novel Vehicles for Delivery of miRNAs in Cancer Therapy

    The authors provide an overview of the properties and potentials of MSCs in cancer therapy as well as the application of MSC-derived exosomes in cancer therapy.
    [Cancer Gene Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Leonhardt Ventures Announces Launch of Research Program Using Patent Pending Klotho Expressing Mesenchymal Stem Cells for Multiple Applications in Combination with Bioelectric Protein Expressions

    Leonhardt Ventures LLC announced that it has begun an active research program to combine its patent-pending klotho expression bioelectric stimulation technologies with newly acquired klotho expressing MSC technology.
    [Leonhardt Ventures (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Antibody Biology and Engineering

    March 13 – 18, 2022
    Ventura, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Regenerative Medicine

    Stanford University – Stanford, California, United States

    PhD Scholarship – Tissue Engineering & Scaffold Design

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Proteome Dynamics

    University of Texas Medical Branch – Galveston, Texas, United States

    Postdoctoral Fellow – Regenerative Medicine

    National University of Ireland Galway – Galway, Ireland

    Postdoctoral Fellowships – Extracellular Vesicles, Microglia and Alzheimer’s Disease

    Mayo Clinic Florida Campus – Jacksonville, Florida, United States

    > See All Jobs

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