 | | Vol. 14.05 – 8 February, 2022 |
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| The authors showed that high-mannose N-linked glycans could serve as a biomarker for the label-free tracking of transplanted human MSCs by mannose-weighted chemical exchange saturation transfer magnetic resonance imaging.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described a de novo dominant neomorphic missense variant in SP7 in a patient with craniosynostosis, cranial hyperostosis, and long bone fragility. Histomorphometry showed increased osteoblasts but decreased bone mineralization.
[Nature Communications] |
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| Researchers characterized changes in the soft tissue sarcoma tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.
[Clinical Cancer Research] |
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| Functional screening showed that the N6-methyladenosine (M6A) demethylase FTO could be a candidate therapeutic target for osteosarcoma (OS). FTO promoted the growth and metastasis of OS in vitro and in vivo.
[Oncogene] |
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| Investigators used engineered cartilage microtissues formed from bone marrow-derived stromal cells or expanded articular chondrocytes to study the impact of enzyme treatment on cartilage tissue integration and matrix remodeling.
[Journal of Tissue Engineering] |
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| To improve the effectiveness of naïve hair follicle-derived-MSC (HF-MSC) treatments on liver cirrhosis (LC), the authors used bioinformatic tools to identify an exogenous gene targeting hepatic stellate cells (HSCs) among the differentially expressed genes in LC to modify HF-MSCs.
[Cell Death Discovery] |
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| Scientists demonstrated that the combination of extrinsic photobiomodulation and collagen-covered microislands could be used to induce differentiation of Wharton’s jelly MSCs with the differentiation direction dictated by the specific island topography without use of chemical factors.
[Scientific Reports] |
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| Researchers compared the neurogenic ability of dental pulp stem cells to bone marrow-derived MSCs under inflammatory stimulation.
[Scientific Reports] |
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| A transwell migration assay was used to investigate recruitment of MDA-MB-231, MCF-7, and MDA-MB-453 breast cancer cells to the osseous polycaprolactone-nano-hydroxyapatite scaffolds.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| The authors unveiled the role of MSCs in regulating the brain sirtuin-1 (SIRT-1) levels following stroke and the involvement of SIRT-1 in regulating inflammasome signaling to reduce cellular apoptosis towards rendering neuroprotection.
[Stem Cell Reviews and Reports] |
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| Exosomes were isolated from the dental pulp tissue and dental pulp stem cells of swine. The effects of the exosomes on apical dental papilla were compared using CKK-8, Transwell, angiogenesis, and odontogenic induction assays.
[International Journal of Nanomedicine] |
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| Investigators demonstrated that bone marrow MSC-derived extracellular vesicles carrying NEAT1 could promote the progression of melanoma by inducing M2 polarization of macrophages, and thus might be considered as a potential target for melanoma therapeutics.
[Cancer Gene Therapy] |
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| Researchers elucidated that exosomal miR-133b-3p from bone marrow MSCs suppressed angiogenesis and oxidative stress in diabetic retinopathy via FBN1 repression.
[Gene Therapy] |
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| The authors summarize the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-extracellular vesicles (EVs), and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation.
[Stem Cell Reviews and Reports] |
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| Scientists summarize the clinical efficacy of MSCs in the treatment of COVID-19 based on published results, including mortality, time to symptom improvement, computed tomography imaging, cytokines, and safety, while elaborating on the possible mechanisms underpinning the effects of MSCs.
[Stem Cell Research & Therapy] |
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| Investigators discuss the mechanisms of platelet mitochondrial translocation and metabolic reprogramming of MSCs, suggesting that platelets or platelet-containing preparations such as platelet-rich plasma may provide a practical guide for tissue injury treatment.
[Platelets] |
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| Calidi Biotherapeutics, Inc., a clinical-stage biotechnology company developing cell-based delivery of oncolytic viruses, and Edoc Acquisition Corp. have entered into a definitive merger agreement.
[Calidi Biotherapeutics, Inc.] |
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| BioRestorative Therapies, Inc. announced that it has initiated the site selection process for its active Phase II clinical trial targeting chronic lumbar disc disease with BRTX-100, a product formulated from autologous cultured MSCs collected from the patient’s bone marrow.
[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] |
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| February 24 – February 25, 2022
Virtual |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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| | Stanford University – Stanford, California, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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