Mesenchymal Cell News Volume 14.09 | Mar 8 2022

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    2022-03-08 | MESCN 14.09


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.09 – 8 March, 2022
    TOP STORY

    Evaluation of Neuroprotective and Immunomodulatory Properties of Mesenchymal Stem Cells in an Ex Vivo Retinal Explant Model

    Labeled rat bone marrow MSCs were placed in coculture with rat retinal explants after optic nerve axotomy. Scientists analyzed the neuroprotective effect of MSCs on retinal ganglion cell survival by immunofluorescence using RBPMS, Brn3a, and NeuN markers.
    [Journal of Neuroinflammation]

    Full Article
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Umbilical Cord Mesenchymal Stem Cell Promotes Angiogenesis via Integrin β1/ERK1/2/HIF-1α/VEGF-A Signaling Pathway for Off-the-Shelf Breast Tissue Engineering

    Allogenic human umbilical cord MSCs were injected into transplanted fat tissue with or without breast scaffolds as an alternative for breast tissue engineering in vivo, and its potential mechanism of angiogenesis in vitro was explored.
    [Stem Cell Research & Therapy]

    Full Article

    The NSUN5-FTH1/FTL Pathway Mediates Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells

    Researchers demonstrated that NOP2/Sun RNA methyltransferase 5 (NSUN5) was downregulated in erastin-induced ferroptosis in bone marrow-derived MSCs.
    [Cell Death Discovery]

    Full Article

    Human Infrapatellar Fat Pad Mesenchymal Stem Cells Show Immunomodulatory Exosomal Signatures

    Investigators hypothesized that infrapatellar fat pad-derived MSCs robust immunomodulatory therapeutic effects were largely exerted via their exosomal secretome by attenuating synoviocytes and macrophages pro-inflammatory activation.
    [Scientific Reports]

    Full Article

    Nectin Cell Adhesion Molecule 4 Regulates Angiogenesis through Src Signaling and Serves as a Novel Therapeutic Target in Angiosarcoma

    Using immunohistochemistry, scientists investigated nectin cell adhesion molecule 4 (NECTIN4) expression in 74 tissue samples from angiosarcoma patients, finding variable NECTIN4 expression.
    [Scientific Reports]

    Full Article

    Safety and Efficacy of Autologous, Adipose-Derived Mesenchymal Stem Cells in Patients with Rheumatoid Arthritis: A Phase I/IIa, Open-Label, Non-Randomized Pilot Trial

    The authors performed a Phase I/IIa non-randomized, open-label study to evaluate the safety and efficacy of a single, intravenous infusion of autologous, adipose-derived MSCs over a period of 52 weeks, in patients with active rheumatoid arthritis.
    [Stem Cell Research & Therapy]

    Full ArticlePress Release

    Effects of Obesity on Reparative Function of Human Adipose Tissue-Derived Mesenchymal Stem Cells on Ischemic Murine Kidneys

    Abdominal adipose tissue-derived mesenchymal stem cell were harvested from patients without or with obesity during kidney donation or bariatric surgery, respectively.
    [International Journal of Obesity]

    Abstract

    Comparative Evaluation of Fracture Healing Potential of Differentiated and Undifferentiated Guinea Pig and Canine Bone Marrow-Derived Mesenchymal Stem Cells in a Guinea Pig Model

    Researchers compared the therapeutic potential of undifferentiated and osteogenic differentiated canine and guinea pig bone marrow MSCs in fracture healing using guinea pigs as a model.
    [Tissue and Cell]

    Abstract

    Therapeutic Efficacy of Adipose-Derived Mesenchymal Stem Cells after Chronic Fluoxetine Treatment on Pars Distalis in Adult Male Albino Rats

    Investigators conducted research to detect the effect of chronic fluoxetine treatment on pars distalis and the possible therapeutic effect of adipose-derived MSCs.
    [Tissue and Cell]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    The Mechanisms of Mutual Relationship between Malignant Hematologic Cells and Mesenchymal Stem Cells: Does It Contradict the Nursing Role of Mesenchymal Stem Cells?

    Scientists study the crosstalk between MSCs and malignant hematologic cells which results in the final feedback of either the progression or suppression of blood cell malignancy.
    [Cell Communication and Signaling]

    Full ArticleGraphical Abstract

    Potential Anticancer Properties and Mechanisms of Thymoquinone in Osteosarcoma and Bone Metastasis

    The authors focus on the characteristics and mechanisms by which thymoquinone exerts its cytotoxic effects on bone malignancies.
    [Cellular & Molecular Biology Letters]

    Full Article
    INDUSTRY AND POLICY NEWS

    Clarkson University Chemical & Biomolecular Engineering Prof Receives $200K NSF Grant

    Clarkson University Assistant Professor of Chemical & Biomolecular Engineering Bethany Almeida has received a $200,000 National Science Foundation (NSF) Engineering Research Initiation grant.
    [Clarkson University]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2022

    April 8-13 |
    New Orleans, Louisiana, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Engineer – Bioprinted Tissue Therapeutics

    Aspect Biosystems – Vancouver, British Columbia, Canada

    Postdoctoral Research Associate – Morphogenesis and Differentiation

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Positions – Human Immunology and Inflammation

    National Institute for Health and Medical Research – Paris, France

    PhD Position – Tumor Tissue Engineering

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Associate – Cell Viability

    Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore

    > See All Jobs

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