 | | Vol. 14.11 – 22 March, 2022 |
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| Scientists demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified the role of p75 signaling pathway in coordinating skeletal cell migration during early bone repair.
[Science Advances] |
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| The authors showed that extracellular vesicles derived from aged bone matrix during bone resorption favored bone marrow MSC adipogenesis rather than osteogenesis and augmented calcification of vascular smooth muscle cells.
[Nature Communications] |
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| Researchers found that the RNA-binding protein Musashi2 regulated bone marrow MSCs (BMSCs) lineage commitment and found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs.
[Bone Research] |
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| Investigators identified novel therapeutic targets for uterine leiomyosarcoma based on transcriptome analysis and assessed the preclinical efficacy of novel drug candidates.
[Clinical Cancer Research] |
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| Scientists presented two series of fibrous and porous hydrogels and used them as substrates to study the mechanoresponses of bone marrow MSCs to stiffness and fibrous structure.
[Biomacromolecules] |
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| The authors revealed the mechanism responsible for the dilated endoplasmic reticulum that is a hallmark characteristic of osteosarcomas and identified a highly conserved molecular signature for this genetically unstable tumor.
[iScience] |
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| Signal transduction and activator of transcription 3 (STAT3) activation increased migration and profibrotic signaling in genome-edited, pericyte-like cells. Conversely, blocking Stat3 inhibited detachment, migration, and profibrotic signaling.
[Cell Reports] |
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| In a wound healing mouse model, the histological evaluation of wound tissue in PBS, bone marrow MSCs (BMSCs), and ascorbic acid 2-glucoside-treated BMSCs group were investigated.
[Stem Cell Research & Therapy] |
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| Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.
[Stem Cell Research & Therapy] |
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| MiR-155-inhibitor-loaded MSC-derived exosomes showed synergistic effects in keratinocyte migration, restoration of FGF-7 levels, and anti-inflammatory action, leading to accelerated wound healing mediated by negative regulation of miR-155.
[Molecular Pharmaceutics] |
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| Proliferation capability, osteogenic lineage commitment, senescence-associated secreted phenotype and circadian oscillation of clock genes under osteogenic condition were assessed in bone marrow MSCs from young adult and aged adult mice.
[Cell Death Discovery] |
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| Researchers found that the expression of the c-Myc oncogene was negatively correlated with T cell infiltration rate in osteosarcoma (OS). Pharmacological inhibition of c-Myc with JQ-1 significantly reduced tumor burden and improved overall survival in an immunocompetent syngeneic murine model of OS.
[Cell Death Discovery] |
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| Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.
[Signal Transduction and Targeted Therapy] |
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| Scientists explored the general characteristics of MSC as delivery tools for cancer therapeutic agents and discuss the potential of oncolytic viruses as immune therapeutics.
[Molecular Therapy-Oncolytics] |
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| Ossium Health, Inc. announced that the US FDA has accepted its Investigational New Drug application for OSSM-001, an MSC product, for the treatment of refractory perianal fistulas in patients with Crohn’s disease.
[Ossium Health, Inc. (Business Wire, Inc.)] |
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| April 27 – May 1, 2022
Riviera Maya, Mexico |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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