Mesenchymal Cell News Volume 14.12 | Mar 29 2022

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    2022-03-29 | MESCN 14.12


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.12 – 29 March, 2022
    TOP STORY

    MicroRNA-378 Contributes to Osteoarthritis by Regulating Chondrocyte Autophagy and Bone Marrow Mesenchymal Stem Cell Chondrogenesis

    MiR-378 amplified osteoarthritis (OA) development via repressing chondrocyte autophagy and by inhibiting bone marrow MSC chondrogenesis, thus indicating miR-378 may be a potential therapeutic target for OA treatments.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Scientific resources to support your cancer research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Bevacizumab Attenuates Osteosarcoma Angiogenesis by Suppressing MIAT Encapsulated by Serum-Derived Extracellular Vesicles and Facilitating miR-613-Mediated GPR158 Inhibition

    Scientists investigated the therapeutic potential of bevacizumab in angiogenesis during osteosarcoma and the related mechanisms.
    [Cell Death & Disease]

    Full Article

    Bone Marrow Mesenchymal Stem Cell-Derived Exosomal microRNA-381-3p Alleviates Vascular Calcification in Chronic Kidney Disease by Targeting NFAT5

    The authors investigated the mechanism of bone marrow MSC-derived exosome using high phosphate stimulated human aortic smooth muscle cells and 5/6 subtotal nephrectomy rat models.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    The Intercellular Communication Between Mesenchymal Stromal Cells and Hematopoietic Stem Cells Critically Depends on NF-κB Signaling in the Mesenchymal Stromal Cells

    Investigators showed that CoCl2-treated MSCs possessed activated NF-κB signalling pathways, and its pharmacological inhibition significantly relieved their growth arrest.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Influence of HEMA on LPS- and LTA-Stimulated IL-6 Release from Human Dental Pulp Cells

    Researchers analyzed the formation of the pro-inflammatory cytokines TNFα and IL-6 in lipopolysaccharide (LPS)- or lipoteichoic acid (LTA)-stimulated cells from the dental pulp interface and pulp fibroblasts in the presence of the resin monomer 2-hydroxyethyl methacrylate (HEMA).
    [Dental Materials]

    Abstract

    Exendin-4 Enhances Osteogenic Differentiation of Adipose Tissue Mesenchymal Stem Cells through the Receptor Activator of Nuclear Factor-Kappa B and Osteoprotegerin Signaling Pathway

    Scientists investigated the decoy receptor osteoprotegerin axis and determined the effect of exendin-4 upon adipose MSC osteogenic differentiation.
    [Journal of Cellular Biochemistry]

    Abstract

    Anti-Inflammatory Effects of Mesenchymal Stem Cell-Conditioned Media Inhibited Macrophages Activation In Vitro

    The authors investigated the anti-inflammatory effects of MSCs on lipopolysaccharide-stimulated macrophages and the subsequent downregulation of their inflammatory mediators.
    [Scientific Reports]

    Full Article

    Spidroin Striped Micropattern Promotes Chondrogenic Differentiation of Human Wharton’s Jelly Mesenchymal Stem Cells

    Scientists directed human Wharton’s jelly-MSCs chondrogenesis using micropattern made of spidroin bioink as opposed to fibronectin that often was used as the gold standard.
    [Scientific Reports]

    Full Article

    Destabilizing Heterochromatin by APOE Mediates Senescence

    Investigators reported that in aged human mesenchymal progenitor cells, apolipoprotein E (APOE) accumulation was a driver for cellular senescence.
    [Nature Aging]

    Abstract

    Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Containing NORAD Promote Osteosarcoma by miR-30c-5p

    Researchers explored the role of non-coding RNA activated by DNA damage (NORAD) derived from extracellular vesicles of bone MSCs in osteosarcoma.
    [Laboratory Investigation]

    Abstract

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Psoriasis-Like Dermatitis by Suppressing IL-17-Producing γδ T Cells

    Human umbilical cord-derived MSCs were subcutaneously injected into mice with imiquimod-induced psoriasis-like skin inflammation to explore the feasibility of this cellular therapy.
    [Cell and Tissue Research]

    AbstractGraphical Abstract

    Lack of Tumorigenesis and Protumorigenic Activity of Human Umbilical Cord Mesenchymal Stem Cells in NOD SCID Mice

    Investigators observed tumor formation in NOD SCID mice after a single subcutaneous injection of human umbilical cord-MSCs and the effect of these cells on tumor growth in tumor-bearing mice.
    [BMC Cancer]

    Full Article

    Dental Pulp Regeneration Induced by Allogenic Mesenchymal Stromal Cells Transplantation in a Mature Tooth: A Case Report

    Researchers evaluated the capacity of allogeneic MSCs to induce dental-pulp and apical bone regeneration in a tooth previously endodontically treated.
    [Journal of Endodontics]

    Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    A Brief Overview of Global Trends in MSC-Based Cell Therapy

    Scientists summarize the biological effects and mechanisms of action of MSCs, elucidating recent clinical trials phases and findings, and highlighting therapeutic effects of MSCs in several representative diseases
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome

    The authors summarize current evidence from in vitro studies, animal models, and their clinical experience, to support stromal cell therapy in multiple clinical indications.
    [Frontiers in Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Stem Cell Biotech Neuroplast Enrolls First Patient in Phase II Clinical Trial of Transformative Neuro-Cells® Treatment for Traumatic Spinal Cord Injury

    Neuroplast has enrolled its first patient in a Phase II clinical trial to evaluate efficacy of its transformative Neuro-Cells® treatment that aims to prevent further damage to the central nervous system after sustaining acute traumatic spinal cord injury.
    [Neuroplast]

    Press Release

    IMAC Holdings, Inc. Announces Initiation of Third and Final Cohort of its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced it has initiated the third and final cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic MSCs for the treatment of bradykinesia due to Parkinson’s disease.
    [IMAC Holdings, Inc. (]

    Press Release

    FEATURED EVENT

    ISSCR 2022 Annual Meeting

    June 15 – 18, 2022
    San Francisco, California, United States

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    JOB OPPORTUNITIES

    PhD Studentship – Mechanisms of Small Cell Lung Cancer Metastasis

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    Postdoctoral Associate – Obesity Related Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    Postdoctoral Researcher – 3D Advanced Microscopy

    University of Barcelona – Barcelona, Spain

    > See All Jobs

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