Mesenchymal Cell News Volume 14.17 | May 3 2022

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    2022-05-03 | MESCN 14.17


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.17 – 3 May, 2022
    TOP STORY

    Colony Stimulating Factor-1 Producing Endothelial Cells and Mesenchymal Stromal Cells Maintain Monocytes within a Perivascular Bone Marrow Niche

    Bone histology revealed that monocytes reside near sinusoidal endothelial cells (ECs) and leptin receptor-expressing perivascular MSCs. Targeted deletion of Csf1 from sinusoidal ECs selectively reduced Ly6C− monocytes, whereas combined depletion of Csf1 from ECs and MSCs further decreased Ly6Chi cells.
    [Immunity]

    Abstract
    Webinar: Bone Marrow Skeletal Progenitors and Bone Diseases
    PUBLICATIONSRanked by the impact factor of the journal

    BAP1 Shapes the Bone Marrow Niche for Lymphopoiesis by Fine-Tuning Epigenetic Profiles in Endosteal Mesenchymal Stromal Cells

    Investigators reported that BAP1 in bone marrow MSCs was critical for the maintenance of hematopoietic stem cells and B lymphopoiesis. Mice lacking BAP1 in MSCs showed aberrant differentiation of hematopoietic stem and progenitor cells, impaired B lymphoid differentiation, and expansion of myeloid lineages.
    [Cell Death & Differentiation]

    Abstract

    Irisin Mediates Beiging of Adipose-Derived Mesenchymal Stem Cells through Binding to TRPC3

    Scientists found that TRPC3 was a key factor in irisin-induced beiging of MSCs, which may provide a new target pathway in addressing metabolic disorders.
    [BMC Biology]

    Full ArticleGraphical Abstract

    Lateral Mesoderm-Derived Mesenchymal Stem Cells With Robust Osteochondrogenic Potential and Hematopoiesis-Supporting Ability

    The authors successfully established an efficient differentiation protocol for the derivation of MSCs with a lateral mesoderm origin from human pluripotent stem cells under specific conditions.
    [Frontiers in Molecular Biosciences]

    Full Article

    A Comprehensive Analysis of the circRNA–miRNA–mRNA Network in Osteocyte-Like Cell Associated with Mycobacterium leprae Infection

    Quantitative reverse-transcription polymerase chain reaction and western blots analyses confirmed decreased Clock expression in osteocyte-like cell, while increased in bone MSCs, implicating a crucial factor in osteogenic differentiation.
    [PLoS Neglected Tropical Diseases]

    Full Article

    Apoptotic Extracellular Vesicles Alleviate PG-LPS Induced Inflammation of Macrophages via AMPK/SIRT1/NF-κB Pathway and Inhibit Adjacent Osteoclasts Formation

    Researchers extracted apoptotic extracellular vesicles (ApoEVs) from bone marrow MSCs and found ApoEVs inhibited macrophages polarizing into the pro-inflammatory condition via AMPK/SIRT1/NF-κB pathway.
    [Journal of Periodontology]

    Abstract

    Sodium Butyrate Induces Hepatic Differentiation of Mesenchymal Stem Cells in 3D Collagen Scaffolds

    The authors explored a novel method for differentiation of bone marrow-derived MSCs into hepatic-like cells using 3D culture conditions and histone deacetylase inhibitor, sodium butyrate.
    [Applied Biochemistry and Biotechnology]

    Abstract

    Long-Term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients with Radiation-Induced Xerostomia: Primary Results of the MESRIX Phase I/II Randomized Trial

    Researchers investigated the long-term safety of autologous adipose tissue-derived MSCs injections into the submandibular glands.
    [Clinical Cancer Research]

    Abstract

    Regorafenib Induces the Apoptosis of Gastrointestinal Cancer-Associated Fibroblasts by Inhibiting AKT Phosphorylation

    Investigators established two in vivo tumor models, the cancer cell line HCT116 with or without MSCs and treated them with regorafenib.
    [Stem Cells and Development]

    Abstract
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    REVIEWS

    Heterogeneity of Mesenchymal Stem Cell-Derived Extracellular Vesicles Is Highly Impacted by the Tissue/Cell Source and Culture Conditions

    The authors focus on the heterogeneity of extracellular vesicles derived from MSCs and summarize upstream process parameters that crucially affect the resulting therapeutic properties and biological functions.
    [Cell & Bioscience]

    Full ArticleGraphical Abstract

    Investigating the Safety and Efficacy of Hematopoietic and Mesenchymal Stem Cell Transplantation for Treatment of T1DM: A Systematic Review and Meta-Analysis

    Based on the results of this meta-analysis, the MSC and its combination with hematopoietic stem cell could be considered as “Safe Cell” for stem cell transplantation in type 1 diabetes mellitus (T1DM).
    [Systematic Reviews]

    Full Article
    INDUSTRY AND POLICY NEWS

    Cynata Starts Trials on Diabetic Foot Ulcer Treatment

    Stem cell biotechnology company Cynata Therapeutics has started clinical trials with an initial cohort of patients in Adelaide of its patented product, aimed at treating diabetic foot ulcers.
    [Cynata Therapeutics Limited (The West Australian)]

    Press Release
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Biology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Assistant – Effects of Chemical Exposure

    Wayne State University – Detroit, Michigan, United States

    Postdoctoral Fellowship – In Vivo Cellular Imaging

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Associate – Planarian Stem Cell Biology and Regeneration

    Baylor College of Medicine – Houston, Texas, United States

    Technician – Cell Culture

    Novo Nordisk – Fremont, California, United States

    > See All Jobs

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