Mesenchymal Cell News Volume 14.18 | May 10 2022

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    2022-05-10 | MESCN 14.18


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.18 – 10 May, 2022
    TOP STORY

    Fibrillin-1 Regulates White Adipose Tissue Development, Homeostasis, and Function

    To elucidate the fibrillin-1-dependent adipogenic mechanisms in cell culture, researchers used primary bone marrow-derived MSCs from Fbn1mgR/mgR, Fbn1C1041G/+ and wild-type mice.
    [Matrix Biology]

    Abstract
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    Identification of Distinct Non-Myogenic Skeletal-Muscle-Resident Mesenchymal Cell Populations

    Investigators identified six distinct Pdgfra+ non-myogenic muscle-resident mesenchymal cell populations that fit within a bipartite differentiation trajectory from a common progenitor.
    [Cell Reports]

    Full ArticleGraphical Abstract

    MDS Cells Impair Osteolineage Differentiation of MSCs via Extracellular Vesicles to Suppress Normal Hematopoiesis

    The authors demonstrated that both human and mouse myelodysplastic syndrome (MDS) cells perturbed bone metabolism by suppressing the osteolineage differentiation of MSCs, which impaired the ability of MSCs to support normal hematopoietic stem cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Adipose Tissue-Derived Mesenchymal Stem Cells’ Acellular Product Extracellular Vesicles as a Potential Therapy for Crohn’s Disease

    Considering the critical roles of macrophage polarization in Crohn’s disease and immunomodulatory properties of MSCs, scientists deciphered the interaction between adipose-derived MSCs and macrophages, including their cytokine production, regulation of differentiation, and pro-/anti-inflammatory function.
    [Journal of Cellular Physiology]

    Full Article

    Wnt/β-Catenin Signaling Pathway Is Involved in Early Dopaminergic Differentiation of Trabecular Meshwork-Derived Mesenchymal Stem Cells

    To examine if Wnt/beta-catenin pathway drives trabecular meshwork-derived MSCs towards a dopaminergic fate, investigators treated them with the Wnt agonist and the Wnt antagonist.
    [Journal of Cellular Biochemistry]

    Abstract

    Extracellular Vesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Protect Rats against Acute Myocardial Infarction-Induced Heart Failure

    Scientists explored the underlying mechanism of bone marrow MSCs-extracellular vesicles in acute myocardial infarction-induced heart failure.
    [Cell and Tissue Research]

    Abstract

    Loss of KDM4B Impairs Osteogenic Differentiation of OMSCs and Promotes Oral Bone Aging

    Investigators found that the histone demethylase KDM4B played an essential role in regulating the osteogenesis of MSCs isolated from oral bones and oral bone aging.
    [International Journal of Oral Science]

    Full Article

    Conditioned Medium from Amniotic Fluid Mesenchymal Stem Cells Could Modulate Alzheimer’s Disease-Like Changes in Human Neuroblastoma Cell Line Sy-SY5Y in a Paracrine Manner

    Researchers investigated the paracrine effect of amniotic fluid-derived MSCs on Alzheimer’s disease changes in human SH–SY5Y cells.
    [Tissue and Cell]

    Abstract

    Conductive Nanocomposite Hydrogel and Mesenchymal Stem Cells for the Treatment of Myocardial Infarction and Non-Invasive Monitoring via Pet/Ct

    The combination of MSCs and the injectable conductive nanocomposite hydrogel offered a promising strategy for myocardial infarction treatment.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Mesh-Like Electrospun Membrane Loaded with Atorvastatin Facilitates Cutaneous Wound Healing by Promoting the Paracrine Function of Mesenchymal Stem Cells

    Scientists established a rat model of wound healing, applied atorvastatin -loaded mesh-like membranes seeded with bone marrow-derived MSCs on wounds, and assessed their efficacy for promoting wound healing.
    [Stem Cell Research & Therapy]

    Full Article
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    REVIEWS

    Mesenchymal Stromal Cells (MSCs) and Their Exosome in Acute Liver Failure (Alf): A Comprehensive Review

    The authors discuss recent progress in preclinical and clinical studies and current challenges in MSCs-based therapies in acute liver failure, with a special focus on in vivo reports.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Umoja Biopharma Announces Activation of First ENLIGHTen Phase I Trial Site in Study of UB-TT170, a TumorTag that Targets Folate Receptors to Mark Tumors for Clearance by CAR T Cells

    Umoja Biopharma, Inc. announced the Seattle Children’s activation of the Phase I ENLIGHTen clinical trial in patients with osteosarcoma to assess the safety and tolerability of autologous “universal” CAR T cells when administered with UB-TT170, the company’s proprietary small molecule fluorescein tag.
    [Umoja Biopharma, Inc.]

    Press Release
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Mesenchymal Stromal Cells

    National University of Ireland Galway – Galway, Ireland

    Postdoctoral Fellow – Cancer Biology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Assistant – Effects of Chemical Exposure

    Wayne State University – Detroit, Michigan, United States

    Postdoctoral Associate – Planarian Stem Cell Biology and Regeneration

    Baylor College of Medicine – Houston, Texas, United States

    Technician – Cell Culture

    Novo Nordisk – Fremont, California, United States

    > See All Jobs

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