Mesenchymal Cell News Volume 14.22 | Jun 7 2022

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    2022-06-07 | MESCN 14.22


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.22 – 7 June, 2022
    TOP STORY

    Adaptive Liquid Interfaces Induce Neuronal Differentiation of Mesenchymal Stem Cells through Lipid Raft Assembly

    Scientists presented an adaptive biomaterial based on two-dimensional networks of protein nanofibrils at a liquid-liquid interface.
    [Nature Communications]

    Full Article
    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Mechanical Activation Drives Tenogenic Differentiation of Human Mesenchymal Stem Cells in Aligned Dense Collagen Hydrogels

    A recently introduced gel aspiration-ejection method was used to rapidly fabricate aligned dense collagen hydrogel scaffolds.
    [Biomaterials]

    AbstractGraphical Abstract

    CircRNA422
    Enhanced Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells during Early Osseointegration through the SP7/LRP5 Axis

    Researchers identified a new circRNA, circRNA422, from rat bone marrow MSCs cultured on sandblasted, large-grit, acid-etched titanium surfaces.
    [Molecular Therapy]

    AbstractGraphical Abstract

    ALX1-Transcribed LncRNA AC132217.4 Promotes Osteogenesis and Bone Healing via IGF-AKT Signaling in Mesenchymal Stem Cells

    Based on differential expression analysis of RNA sequencing data, scientists found that lncRNA AC132217.4, a 3’UTR-overlapping lncRNA of insulin growth factor (IGF) 2, was highly induced during the osteogenic differentiation of bone marrow MSCs.
    [Cellular and Molecular Life Sciences]

    Abstract

    In Vitro Generation of Transplantable Insulin-Producing Cells from Canine Adipose-Derived Mesenchymal Stem Cells

    In vitro preservation of pluronic F127-coated alginate-encapsulated canine adipose MSCs-derived insulin-producing cells (IPCs) was performed to verify ready-to-use IPCs.
    [Scientific Reports]

    Full Article

    Enhanced Osteogenic Differentiation of Mesenchymal Stem Cells by Surface Lithium Modification in a Sandblasted/Acid-Etched Titanium Implant

    The osteogenesis-related cell response to the surface lithium ion-modified sandblasted/acid-etched sample was evaluated using two kinds of murine bone marrow stem cells, bipotent ST2 cells and primary multipotent MSCs.
    [Journal of Biomaterials Applications]

    Abstract

    Foxf2 Represses Bone Formation via Wnt2b/β-Catenin Signaling

    Through a comprehensive analysis of gene expression during the differentiation of MSCs into osteoblasts, the authors showed that the forkhead transcription factor Foxf2 was a crucial regulator of this process.
    [Experimental & Molecular Medicine]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Mesenchymal Stroma/Stem Cells: Hematologists’ Friend or Foe?

    Investigators review the clinical experience with use of MSCs in hematopoietic stem cell transplantation for enhancement of engraftment, prevention, and treatment of graft-versus-host disease and hemorrhagic cystitis.
    [British Journal of Haematology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Lytix Biopharma AS Announces That LTX-315 in Combination with Adoptive Cell Therapy Has Been Shown to Generate Tumor-Specific T Cells and Stabilize the Disease in Patients with Progressive Metastatic Soft Tissue Sarcoma (STS)

    Lytix Biopharma AS announced data from its ATLAS-IT-04 trial in patients with metastatic STS. The data from this Phase II proof of concept study showed that LTX-315 in combination with adoptive cell therapy was able to stabilize the disease in 3 out of 4 fully treated patients.
    [Lytix Biopharma AS (Oslo Børs)]

    Press Release

    FEATURED EVENT

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    November 16 – 18, 2022
    Melbourne, Victoria, Australia

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