Mesenchymal Cell News Volume 14.23 | Jun 14 2022

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    2022-06-14 | MESCN 14.23


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.23 – 14 June, 2022
    TOP STORY

    R-SPONDIN2+ Mesenchymal Cells Form the Bud Tip Progenitor Niche during Human Lung Development

    Functional experiments using organoid models, explant cultures, and FACS-isolated RSPO2+ mesenchyme showed that RSPO2 was a critical niche cue that potentiated WNT signaling in bud tip progenitors to support their maintenance and multipotency.
    [Developmental Cell]

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    PUBLICATIONSRanked by the impact factor of the journal

    Exosomes Derived from Magnetically Actuated Bone Mesenchymal Stem Cells Promote Tendon-Bone Healing through the miR-21-5p/SMAD7 Pathway

    Investigators isolated and characterized two types of exosomes, conducted in vitro experiments to measure their effects on fibroblasts, and performed in vivo experiments to compare the effects on tendon-to-bone integration.
    [Materials Today Bio]

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    Long Noncoding RNA ZBTB40-IT1 Regulates Bone Mass by Directing the Differentiation of Human Bone Marrow Mesenchymal Stromal Cells via the microRNA-514a-3p/FOXO4 Axis

    Researchers clarified the mechanism of long noncoding RNA ZBTB40-IT1 in directing human bone marrow-derived MSC (hBMSC) differentiation. hBMSCs underwent osteogenic and adipogenic induction, and an osteoporosis mouse model was established via ovariectomy.
    [Human Cell]

    Abstract

    Activin B-Activated Cdc42 Signaling Plays a Key Role in Regulating Adipose-Derived Mesenchymal Stem Cells-Mediated Skin Wound Healing

    The dominant-negative mutant of Cdc42 was used to explore the role of Cdc42 in activin B-induced adipose-derived MSC migration, proliferation, and secretion in vitro.
    [Stem Cell Research & Therapy]

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    Adipose-Derived Mesenchymal Stem Cells Reprogram M1 Macrophage Metabolism via PHD2/HIF-1α Pathway in Colitis Mice

    Investigators treated DSS-induced colitis mice with adipose‐derived MSCs (ADMSCs) and revealed that ADMSCs alleviated colon inflammation by reducing the infiltration of M1 macrophages.
    [Frontiers in Immunology]

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    Mesenchymal Stem Cells Exert Their Anti-Asthmatic Effects through Macrophage Modulation in a Murine Chronic Asthma Model

    Scientists evaluated the anti-asthmatic effects of MSCs primed with Liproxstatin-1, a potent ferroptosis inhibitor.
    [Scientific Reports]

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    REVIEWS

    Mesenchymal Stromal/Stem Cells Spheroid Culture Effect on the Therapeutic Efficacy of These Cells and Their Exosomes: A New Strategy to Overcome Cell Therapy Limitations

    Due to the novelty of the field of using 3D culture MSCs-derived exosomes, examination of their properties and the results of their therapeutic application can increase the authors’ views of this field, as they discuss MSCs and their exosomes enhanced properties in spheroid culture.
    [Biomedicine & Pharmacotherapy]

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    Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage

    Investigators discuss the pathological mechanisms following intracerebral hemorrhage and the therapeutic mechanisms of MSC-based therapy to unravel new cues for future therapeutic strategies.
    [Frontiers in Cellular Neuroscience]

    Full Article
    INDUSTRY AND POLICY NEWS

    Immunicum AB: Immunicum Received FDA Orphan Drug Designation for Ilixadencel as Treatment of Gastrointestinal Stromal Tumors (GIST)

    Immunicum AB announced that it has been granted an orphan drug designation from the US FDA for ilixadencel in the treatment of GIST. A rare and difficult to treat subgroup of cancers referred to as soft tissue sarcoma.
    [Immunicum AB]

    Press Release
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    JOB OPPORTUNITIES

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