 | | Vol. 14.25 – 28 June, 2022 |
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| Investigators explored the possibility of using MSCs derived from human gingival tissues for studying their ex vivo growth characteristics and differentiation potential with respect to donor age.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated the ability of human MSC (hMSC)-secreted extracellular matrix to augment lymphangiogenesis by using an in vitro co-culturing model of hMSC sheets with lymphatic endothelial cells and an in vivo mouse tail lymphedema model.
[Advanced Healthcare Materials] |
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| Using human dental MSCs, the authors demonstrated that nerve growth factor (NGF) mediated osteogenic differentiation through p75NTR, a low-affinity nerve growth factor receptor.
[Stem Cells] |
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| Investigators showed that autologous stem cell transplantation apheresis products were a suitable source of T cells for anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell manufacture.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists proposed a novel method to screen MSCs with high migration capacity and confirmed that these MSCs exhibited higher osteogenic differentiation ability both in vivo and in vitro.
[Cellular Signalling] |
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| Human MSCs were cultured in the presence of inflammatory mediators typically associated with osteoarthritis pathology.
[Frontiers in Bioengineering and Biotechnology] |
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| Scientists examined the ability of small interfering RNA to enhance osteoblast differentiation and bone formation by silencing the negative suppressor gene GNAS in bone MSCs.
[Molecular Therapy] |
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| Investigators generated a new transgenic chondrosarcoma model by double conditional deletions of Trp53 and Rb1 in chondrocyte lineage which spontaneously caused spinal chondrosarcoma and lung metastasis.
[Cell Death & Disease] |
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| Researchers isolated human adipose-MSCs, and found that early growth response factor-1, smooth muscle, and endothelial cell enriched migration/differentiation-associated long-noncoding RNA (lncRNA-SENCR) and achieved vascular endothelial growth factor-A (VEGF-A) overexpression or knockdown.
[Human Cell] |
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| Scientists assessed the potential protective effects of MSCs against colistin-induced neurotoxicity and the possible mechanisms underlying any effect.
[Toxicology Mechanisms and Methods] |
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| Investigators report that glucose is the primary energy substrate for MSCs, provides precursors for biomass generation, and regulates MSC functions, including proliferation, differentiation, and immunosuppressive properties.
[Tissue Engineering Part B-Reviews] |
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| The authors review the beneficial effects of MSC transplantation in spinal cord injury clinical studies with a special focus on the MSC properties and limitations of MSC transplantation.
[Cell and Tissue Research] |
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| A surgeon who just a decade ago was celebrated around the globe as a pioneer in stem cell transplants has been convicted of one count of “causing bodily harm,” a felony, in a Swedish court.
[ScienceInsider] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | National University of Ireland Galway – Galway, Ireland |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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