 | | Vol. 14.31 – 9 August, 2022 |
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| The authors showed that pancreas-derived MSCs were capable of regenerating exocrine pancreas when implanted into the kidney capsule of mice with streptozotocin–induced diabetes.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers suggested that an intricate homeostatic balance between hematopoietic stem cells and proximal hematopoietic progenitors was regulated by cell competition for limited amounts of membrane-bound stem cell factor.
[Nature Communications] |
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| Scientists reported that most high-grade pediatric osteosarcomas maintained their telomeres by alternative lengthening of telomeres (ALT), and that the majority of these ALT tumors were ATRX wild-type and instead carried an amplified 17p11.2 chromosomal region containing TOP3A.
[EMBO Molecular Medicine] |
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| The wrist and knuckle epitopes of bone morphogenetic protein 2 (BMP-2 screened to identify peptides with potential osteogenic properties.
[Advanced Healthcare Materials] |
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| The authors suggested a novel strategy to treat triple negative breast cancer (TNBC) using MSC-derived extracellular vesicles to transform the behaviors and cellular communication of TNBC cells with other non-cancer cells related to tumorigenesis and metastasis.
[Scientific Reports] |
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| Researchers found that upregulation of miR-551b-5p suppressed the proliferation and migration and induced the apoptosis of breast cancer cells via downregulating tripartite motif-containing protein 31 (TRIM31).
[Human Cell] |
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| | Scientists performed a Phase I/IIa, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs in the treatment of psoriasis and preliminarily explored the possible mechanisms.
[Signal Transduction and Targeted Therapy] |
| | Investigators engineered adipose-derived MSCs (ADSCs) to overexpress hematopoietic prostaglandin D synthase (ADSCHpgds) and evaluated its effects on diabetic wound healing using a full-thickness skin wound model.
[Stem Cell Research & Therapy] |
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| The authors characterized the potential role of follistatin-like 1 in MSC-based anti-fibrotic therapy and further elucidated the mechanisms underlying its action.
[Stem Cell Research & Therapy] |
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| Scientists provide an update on recent clinical applications using either human pluripotent stem cells or MSCs derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.
[Signal Transduction and Targeted Therapy] |
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| The authors review the influences of umbilical cord-derived MSCs on breast cancer and summarize this with a focus on the molecular mechanisms involved in its pathogenesis and treatment.
[Molecular Biology Reports] |
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| Rain Therapeutics, Inc. announced completion of enrollment in its Phase III MANTRA randomized, global, registrational trial of its lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53.
[Rain Therapeutics, Inc.] |
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| October 10 – 12, 2022
Lausanne, Switzerland |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | German Cancer Research Center in the Helmholtz Association – Dresden, Germany |
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| | Essen University Hospital – Essen, Germany |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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