Mesenchymal Cell News Volume 2.09 | Mar 9 2010

TOP STORY

Offering Hope for Tissue Regeneration
Researchers have discovered how cells communicate with each other during times of cellular injury. [Press release from the Rhode Island Hospital discussing the online prepublication in Experimental Hematology]

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SCIENCE NEWS

Theory of Single Stem Cell for Blood Components Challenged
Components of the blood or hematopoietic system derive from stem cell subtypes rather than one single stem cell that give rise to all the different kinds of blood cells equally. [Press release from the Baylor College of Medicine discussing the online prepublication in Cell Stem Cell]

Breakthrough Reveals Blood Vessel Cells Are Key to Growing Unlimited Amounts of Adult Stem Cells
In a leap toward making stem cell therapy widely available, researchers have discovered that endothelial cells produce growth factors that can grow copious amounts of adult stem cells and their progeny over the course of weeks. [Press release from the Weill Cornell Medical College discussing the online prepublication in Cell Stem Cell]

CURRENT PUBLICATIONS

Endothelial Cells are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
Researchers developed angiogenic models to demonstrate that endothelial cell-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic long-term hematopoietic stem cells. [Cell Stem Cell]

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by Transforming Growth Factor Beta 1
This study demonstrates definitive isolation of lineage-biased hematopoietic stem cells subtypes and contributes to the fundamental change in view that the hematopoietic system is maintained by a continuum of hematopoietic stem cells subtypes, rather than a functionally uniform pool. [Cell Stem Cell]

Cadherin-Based Adhesion is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow
Data suggests that enhanced cell adhesion may protect hematopoietic stem cells (HSCs) against various stresses and promote long-term maintenance of the HSC pool. [Cell Stem Cell]

Insufficient Evidence for Association of NOD2/CARD15 or Other Inflammatory Bowel Disease-Associated Markers on Graft-Versus-Host Disease Incidence or Other Adverse Outcomes in T-Replete, Unrelated Donor Transplantation
The results do not support an association between the 3 inflammatory bowel disease-associated single nucleotide polymorphisms and adverse outcomes following matched unrelated donor hematopoietic cell transplantations in American patients. [Blood]

Bone Marrow-Derived Mesenchymal Stem Cells Prevent the Loss of Niemann-Pick Type C Mouse Purkinje Neurons by Correcting Sphingolipid Metabolism and Increasing Sphingosine-1-Phosphate
Researchers found that Niemann-Pick type C Purkinje neurons exhibit abnormal sphingolipid metabolism and defective lysosomal calcium store compared to wild type Purkinje neurons. [Stem Cells]

Towards an Intraoperative Engineering of Osteogenic and Vasculogenic Grafts from the Stromal Vascular Fraction of Human Adipose Tissue
This study investigates the feasibility of an intraoperative approach to engineer cell-based bone grafts with tissue harvest, cell isolation, cell seeding onto a scaffold and subsequent implantation within a few hours. [Eur Cell Mater]

A Protocol for Isolation and Culture of Mesenchymal Stem Cells from Mouse Compact Bone
Investigators provide an easy and reproducible method to harvest mouse mesenchymal stem cells that does not require depletion of hematopoietic cells by sorting or immunomagnetic techniques. [Nat Protoc]

Microvesicle Entry into Marrow Cells Mediates Tissue-Specific Changes in mRNA by Direct Delivery of mRNA and Induction of Transcription
The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA. [Exp Hematol]

Human Bone Marrow Mesenchymal Stem Cells Expressing Stromal Cell-Derived Factor-1 Promote Hematopoietic Stem cell Function of Human Mobilized Peripheral Blood CD34⁺ Cells In Vivo and In Vitro
This study was aimed to assess whether bone marrow mesenchymal stem cells overexpressing exogenous stromal cell-derived factor-1 could synergistically promote the homing of CD34⁺ (Cluster of Differentiation) cells to bone marrow of lethally irradiated severe combined immunodeficiency mice. [Int J Radiat Biol]

INDUSTRY NEWS

Key Bone Repair Patent Granted in the United States
Mesoblast Limited recently announced that the United States Patent and Trademark Office has granted a key patent that provides exclusive commercial protection for its bone tissue generating products through to at least the year 2019 in the United States. [Mesoblast Limited Press Release]

Axiogenesis Announces Worldwide, Exclusive Distribution Agreement with Lonza Cologne
The agreement includes Axiogenesis’s current product and service portfolio, including the industry standard Cor.At^® mouse embryonic stem cell-derived cardiomyocytes. [Axiogenesis AG Press Release]

Entest BioMedical Announces Creation of Proprietary Adult Stem Cell Lines
Entest BioMedical Inc. announced the creation of three bone marrow derived-stem cell lines useful for optimizing laser intensities and wavelengths in laser enhanced stem cell therapy. [CNN Money]

NeoStem Enters into a Sponsored Research Agreement with University of Michigan; Funding from the National Institutes of Health Stem Cell Research Grant
NeoStem, Inc. announced that it has entered into a sponsored research agreement with the University of Michigan to evaluate bone defect repairs using human stem cells. [PR Newswire]

Using Own Skin Cells to Repair Hearts on Horizon
A heart patient’s own skin cells soon could be used to repair damaged cardiac tissue thanks to pioneering stem cell research of the University of Houston’s newest biomedical scientist, Robert Schwartz. [University of Houston Press Release]

Stem Cell Research Center to Open at University of California, Davis Med Center
University of California, Davis will open a $62 million stem cell facility at its medical center campus in Sacramento. [Sacramento Business Journal]

POLICY NEWS

Canadian Budget Light on New Research Dollars
Relief was the order of the day for Canadian scientists on Thursday as the federal government brought down its fiscal blueprint for 2010-11. [Conservative Party, Canada]

In Annual Rite, Chinese Science Showered With Riches
At the opening session of the National People’s Congress, officials announced that the science and technology budget will rise 8% to 163.3 billion RMB ($24 billion) in 2010. [National People’s Congress, China]

Guidance for Industry: Characterization and Qualification of Cell Substrates and Other Biological Materials Used in the Production of Viral Vaccines for Infectious Disease Indications, 9905-9906 [2010-4553] [Food and Drug Administration, United States]

Request for Information (RFI): To Solicit Input for the National Institute of General Medical Sciences (NIGMS) Strategic Plan for Training and Career Development (NOT-GM-10-102) [National Institutes of Health, United States]

Correction to Required Budget Component for PAR-09-084: Enhancing Developmental Biology Research at Undergraduate Institutions Academic Research Enhancement Award (R15) (NOT-HD-10-007) [National Institutes of Health, United States]

Clarification of Budget Form for PAR-09-092 Academic-Community Partnership Conference Series (U13) (NOT-HD-10-009) [National Institutes of Health, United States]

Recovery Act Limited Competition: The National Institutes of Health Director’s American Recovery & Reinvestment Act Funded Pathfinder Award to Promote Diversity in the Scientific Workforce (DP4) (RFA-OD-10-013) [National Institutes of Health, United States]

Minority Access to Research Careers Undergraduate Student Training in Academic Research (U-STAR) National Research Service Award (NRSA) Institutional Research Training Grant (T34) (PAR-10-119) [National Institutes of Health, United States]

EVENTS

36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology (TT) Meeting
March 22-24, 2010
Berlin, Germany

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

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