Mesenchymal Cell News Volume 2.14 | Apr 13 2010

TOP STORY

Magnetic Attraction of Stem Cells Creates More Potent Treatment for Heart Attack
Researchers have found in animals that infusing cardiac-derived stem cells with micro-size particles of iron and then using a magnet to guide those stem cells to the area of the heart damaged in a heart attack boosts the heart’s retention of those cells and could increase the therapeutic benefit of stem cell therapy for heart disease. [Press release from EurekAlert! discussing online prepublication in Circulation Research]

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SCIENCE NEWS

Supplement Your Stem Cells
Recent research suggests that a commercially-available supplement can increase the blood circulation of hematopoietic stem cells, which can give rise to all blood cells, and endothelial progenitor cells. [Press release from EurekAlert! discussing online prepublication in Journal of Translational Medicine]

Scientists Grow Replacement Blood Vessels from Stem Cells
Blood vessels engineered from laboratory-grown stem cells have worked well in animals, researchers say, and might someday replace the synthetic products now in use. [HealthDay Press Release]

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CURRENT PUBLICATIONS

Long-Term Outcome and Late Effects in Patients Transplanted with Mobilized Blood or Bone Marrow: A Randomized Trial
More than nine years after transplantation, overall and leukemia-free survival remains similar in patients who underwent bone-marrow transplantation and peripheral blood progenitor cell transplantation. [Lancet Oncol]

Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction
Investigators sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. [Circ Res]

Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium
Results demonstrate the in vitro and in vivo salutary effects of genetic modification of stem cells. Specifically, overexpression of chemokine receptor enhances the migration, survival and engraftment of mesenchymal stem cells, and may provide a new therapeutic strategy for the injured myocardium. [Circ Res]

Generation of Induced Pluripotent Stem Cells from Human Adipose-Derived Stem Cells Without c-MYC
Results show that human induced pluripotent stem cells can be generated by the transduction of three factors (OCT3/4, SOX2, and KLF4) into human adipose-derived stem cells. [Tissue Eng Part A]

Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain
Data indicate the usefulness of green fluorescent protein for investigating the survival of mesenchymal stem cells following transplantation to the brain. [Neurorehabil Neural Repair]

Angiogenic Effects Despite Limited Cell Survival of Bone Marrow-Derived Mesenchymal Stem Cells Under Ischemia
This study suggests that mesenchymal stem cell transplantation may be an effective and clinically relevant tool in the therapy of occlusive arterial diseases. [Thorac Cardiovasc Surg]

Comparison of Proliferative and Multilineage Differentiation Potentials of Cord Matrix, Cord Blood, and Bone Marrow Mesenchymal Stem Cells
Umbilical cord matrix mesenchymal stem cells are a dependable source of an unlimited number of mesenchymal stem cells for autologous and allogenic use in regenerative medicine. [Asian J Transfus Sci]

INDUSTRY NEWS

Institute Forms Partnership with Group in Tokyo
The Wake Forest Institute for Regenerative Medicine has formed an international partnership that holds promise for accelerating the pace of developing therapies for patients. [Winston-Salem Journal]

AllCells LLC Announces Facilities Expansion
AllCells LLC recently announced it has completed its expansion into 10,000 additional square feet of office and laboratory production space located in Emeryville, California. [Business Wire]

Regenerative Medical Firm Plans to Expand Operations
Stemnion, a privately held company taking an innovative approach to treating wounds through regenerative medicine, has finished enrollment for first-phase clinical trials and is expanding its South Oakland operations. [Pittsburgh Post-Gazette]

Bay Street Says Life Sciences Fare Better in United States
Canadian life sciences companies that need to raise cash in capital markets are best served going south of the border for their financing needs, Bay Street specialty bankers said. [Reuters]

POLICY NEWS

University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues
Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States]

National Human Genome Research Institute Names New Chief of Genome Technology Branch
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States]

Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States]

Clinical Investigator Status (Biologics) [Center for Biologics Evaluation and Research, United States]

Background on Study Results of U.S. Academic Researchers [Center for Biologics Evaluation and Research, United States]

May 7, 2010: Vaccines and Related Biological Products Advisory Committee Meeting Announcement [Center for Biologics Evaluation and Research, United States]

Vaccines and Related Biological Products Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Food and Drug Administration, United States]

EVENTS

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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