Mesenchymal Cell News Volume 2.15 | Apr 20 2010

TOP STORY

How Can You Heal a Broken Heart?
Researchers are evaluating the safety, feasibility and efficacy of injecting stem cells into the hearts of patients while they are undergoing coronary bypass surgery. [Research Centre of the Centre Hospitalier de l’Université de Montréal Press Release]

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SCIENCE NEWS

Glass Helps Damaged Bone Regenerate
The goal is to place in the body a glass “scaffold” that promotes transport of blood and nutrients through interconnected pores and allows new cells to grow, without causing infection or a systemic reaction. [Lehigh University Press Release]

Human Development Index Linked to Stem Cell Transplant Rates and Success in Leukemia Patients
A new study reports that in Europe, socioeconomic factors have a direct correlation to the rates and outcomes of stem cell transplantation for patients with acute myeloid leukemia. [Press release from PRNewswire discussing online prepublication in Blood]

Bioheart Commenced Successful Regenerative Stem Cell Treatments with Latin American Patients Having Congestive Heart Failure
Bioheart, Inc. announced that treatment with stem cell therapy on two congestive heart failure patients was performed successfully at the Hospital Angeles Tijuana, Mexico, through Bioheart’s Center of Excellence program with Regenerative Medicine Institute. [PRNewswire Press Release]

Intravenous Administration of Endometrial Regenerative Cells Induces Benefit in Heart Failure Patient
Medistem Inc. reported a recent publication in the peer reviewed journal International Archives of Medicine describing a 74 year old heart failure patient treated with the company’s endometrial regenerative cell product in November 2007. [Marketwire]

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CURRENT PUBLICATIONS

High-Dose Therapy and Autologous Stem-Cell Transplantation in Waldenström Macroglobulinemia: The Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
The aim of this study was to analyze the results of autologous stem cell transplantation in patients with Waldenström macroglobulinemia and to determine the prognostic factors that have a significant impact on outcome. [J Clin Oncol]

Association of Human Development Index with Rates and Outcomes of Hematopoietic Stem Cell Transplantation for Patients with Acute Leukemia
Researchers conclude that in Europe, the human development Index is associated with both rates and results of hematopoietic stem cell transplantation for acute leukemia. [Blood]

Positioning of Bone Marrow Hematopoietic and Stromal Cells Relative to Blood Flow In Vivo: Serially Reconstituting Hematopoietic Stem Cells Reside in Distinct Non-Perfused Niches
To investigate functional attributes of hematopoietic stem cells niches, mice were perfused with Hoechst33342 in vivo before bone marrow cell collection in presence of pump inhibitors and antibody stained. [Blood]

Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy
In this study, investigators evaluated whether adipose-derived mesenchymal stromal/stem cells could deliver proapoptotic molecules for cancer treatment. [Cancer Res]

The Chondrogenic Differentiation of Mesenchymal Stem Cells on an Extracellular Matrix Scaffold Derived from Porcine Chondrocytes
In this study, an extracellular matrix scaffold derived from porcine cartilage was evaluated for whether it can support and maintain chondrogenesis of rabbit mesenchymal stem cells in vitro and in the nude mouse model in vivo. [Biomaterials]

Distinct Stem Cells Subpopulations Isolated from Human Adipose Tissue Exhibit Different Chondrogenic and Osteogenic Differentiation Potential
The obtained results underline the complexity of the ASCs population demonstrating that it is composed of several subpopulations, which express different levels of adipose stem cells markers and exhibit distinctive differentiation potentials. [Stem Cell Rev]

Autologous Bone Marrow-Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation: An Observational Cohort Study
This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow-derived mesenchymal stem cells. [Am J Sports Med]

Stem Cells Genetically Modified With the Developmental Gene MT1-MMP Improve Regeneration of the Supraspinatus Tendon-to-Bone Insertion Site
Mesenchymal stem cells genetically modified to overexpress the developmental gene MT1-MMP can augment rotator cuff healing at 4 weeks by the presence of more fibrocartilage at the insertion and improved biomechanical strength.  [Am J Sports Med]

Membrane Properties of Neuron-Like Cells Generated from Adult Human Bone Marrow-Derived Mesenchymal Stem Cells
Adult mesenchymal stem cells isolated from human bone marrow generated neural stem cell-like cells were subjected to current pulses in order to determine if they were capable of generating depolarization-induced action potentials. [Stem Cells Dev]

How to Track Cellular Aging of Mesenchymal Stromal Cells?
Researchers demonstrated that gene expression changes and epigenetic modifications are continuously acquired during replicative senescence. [Aging]

INDUSTRY NEWS

Einstein Receives $10 Million National Institutes of Health Grant to Expand Stem Cell Research Facilities
Albert Einstein College of Medicine of Yeshiva University has been awarded $10 million from the National Institutes of Health to expand its stem cell research capabilities. [Albert Einstein College of Medicine Press Release]

Stimulating Healing in the Heart
A startup aims to repair heart damage with peptides that trigger the proliferation of heart cells. [Technology Review by Massachusetts Institute of Technology]

Regenerative Medicine Company Wants Biobusiness Center Space
A start-up biotech company will seek Rochester City Council approval to put a manufacturing facility in the Minnesota Biobusiness Center. [The Post-Bulletin]

Florida Biotech Research Money in Jeopardy
Florida researchers could lose $50 million in biomedical research funding due to the state’s $3 billion budget deficit. [Orlando Business Journal]

Quebec Biotechs in Tailspin
Once Canada’s envy, and in the same league as Boston and San Francisco, Quebec’s biotechnology industry is a shadow of its former self and in danger of disappearing, observers say. [The Gazette]

POLICY NEWS

Stem Cell Funding in Sight
Two of the most widely used embryonic stem cell lines could be just weeks away from being eligible for United States federal funding. [Obama Administration, United States]

Obama Picks Pragmatists for New Bioethics Panel
President Barack Obama named the members of his bioethics commission – headed by two university presidents. [National Bioethics Commission, United States]

Policy Reminder Concerning Appendix Materials for All National Institutes of Health/Agency for Healthcare Research and Quality/National Institute for Occupational Safety and Health Grant Applications (NOT-OD-10-077) [National Institutes of Health, United States]

Enhancing Peer Review: Clarification of Resubmission Policy and Determination of New Application Status (NOT-OD-10-080) [National Institutes of Health, United States]

Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving Animals (NOT-OD-10-081) [National Institutes of Health, United States]

Update of Sample Animal Welfare Assurance for Foreign Institutions (NOT-OD-10-083) [National Institutes of Health, United States]

Agency for Healthcare Research and Quality Small Research Grant Program (R03) (PAR-10-168) [National Institutes of Health, United States]

Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P) List of Registered Establishments [Center for Biologics Evaluation and Research, United States]

Preparation for International Conference on Harmonization Steering Committee and Expert Working Group Meetings in Tallinn, Estonia; Regional Public Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

EVENTS

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

European Molecular Biology Laboratory (EMBL) Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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