Mesenchymal Cell News Volume 2.22 | Jun 8 2010

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    Mesenchymal Cell News 2.22, June 8, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe


    TOP STORY

    Synovial Sarcoma is a Stem Cell Malignancy
    Collectively, these data suggest that a human multipotent mesenchymal stem cell can serve as a cell of origin for synovial sarcoma (SS) and SS is a stem cell malignancy resulting from dysregulation of self-renewal and differentiation capacities driven by SS18-SSX fusion protein. [Stem Cells]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    DNAJB6 Induces Degradation of Beta-Catenin and Causes Partial Reversal of Mesenchymal Phenotype
    Researchers revealed that MRJ(L) expression causes changes in cell morphology concomitant with down-regulation of several mesenchymal markers viz. Vimentin, N-cadherin, Twist, Slug and up-regulation of epithelial marker, Keratin 18. [J Biol Chem]

    Polyampholytes as Cryoprotective Agents for Mammalian Cell Cryopreservation
    The results indicate that these polymeric extracellular cryoprotective agents (CPAs) may replace current CPAs and the high viability after thawing and non-necessity of serum ensure that these CPAs may be used in various preservation fields. [Cell Transplant]

    Non-Senescent Hsp27-Upregulated MSCs Implantation Promote Neuroplasticity in Stroke Model
    In this study, researchers demonstrated that implantation of human umbilical cord mesenchymal stem cells cultured in human umbilical cord serum significantly enhanced neuroplasticity and angiogenesis in stroke and ischemic limb models. [Cell Transplant]

    Loss of Stromal Caveolin-1 Leads to Oxidative Stress, Mimics Hypoxia and Drives Inflammation in the Tumor Microenvironment, Conferring the “Reverse Warburg Effect”: A Transcriptional Informatics Analysis with Validation
    Using an unbiased informatics analysis of the transcriptional profile of Cav-1 (-/-) deficient mesenchymal stromal cells, researchers have now identified many of the major signaling pathways that are activated by a loss of Cav-1, under conditions of metabolic restriction (with low glucose media). [Cell Cycle]

    Promotion of Human Adipose-Derived Stem Cell Proliferation Mediated by Exogenous Nucleosides
    The results support the importance of the nucleoside supplementation of media to improve conditions for the expansion and maintenance of human adipose-derived stem cells in culture. [Cell Biol Int]

    Mesenchymal Stromal Cells for Steroid-Refractory Acute Graft-Versus-Host Disease: A Report of Two Cases
    Here researchers have reported two cases of the patients with acute steroid-refractory graft-versus-host disease who underwent allogeneic hematopoietic stem cell transplantation. [Int J Hematol]

    INDUSTRY NEWS

    30 Johns Hopkins Researchers Receive Maryland Stem Cell Funding
    Thirty Johns Hopkins researchers have been awarded funding from the Maryland Stem Cell Research Commission under the Maryland Stem Cell Research Act of 2006. [Johns Hopkins Medicine Press Release]

    Costa Rica Puts Brakes on Popular Stem Cell Tourism
    Costa Rica is cracking down on an unauthorized stem cell clinic that has attracted hundreds of foreigners seeking relief from degenerative diseases and serious injuries. [Reuters]

    EU Merger Update
    PTS, Inc. announced that it is preparing a Letter of Intent to merge with a European tissue engineering company. [PR Newswire]

    Derma Sciences Receives CE Mark for ALGICELL(R) Ag
    Derma Sciences, Inc. announced that its ALGICELL® Ag wound dressings have received a CE mark for use in the European Union. SGS Group, the world’s largest Control and Inspection Company, supervised the assessment and certification process. [PR Newswire]

    POLICY NEWS

    STAR METRICS: New Way to Measure the Impact of Federally Funded Research
    A new initiative–Science and Technology for America’s Reinvestment: Measuring the Effect of Research on Innovation, Competitiveness and Science, or STAR METRICS–promises to monitor the impact of federal science investments on employment, knowledge generation, and health outcomes. [National Institutes of Health, United States]

    Administrative Supplements to Increase Public Awareness of Pediatric Cancers and Available Treatments and Research (NOT-CA-10-026) [National Institutes of Health, United States]

    Heart Failure Clinical Research Network Regional Clinical Centers (U10) (RFA-HL-12-001) [National Institutes of Health, United States]

    FDA Announces Collaboration with Drugs.com
    The U.S. Food and Drug Administration announced that it will collaborate with the website Drugs.com to expand access to the FDA’s consumer health information. [Food and Drug Administration, United States]

    2010 Biological License Application Approvals [Food and Drug Administration, United States]

    2010 Biological Device Application Approvals [Food and Drug Administration, United States]

    Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety Public Workshop (Update) [Food and Drug Administration, United States]

    EVENTS

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
    June 13-17, 2010
    Galway, Ireland

    International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
    June 16-19, 2010
    San Francisco, United States

    United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
    July 12-14, 2010
    Nottingham, United Kingdom

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
    September 15-17, 2010
    Sydney, Australia

    5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
    October 5-7, 2010
    Hannover, Germany

    2010 American Society for Matrix Biology (ASMB) Meeting
    October 24-27, 2010
    Charleston, United States

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
    December 5-8, 2010
    Orlando, United States

    Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

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