SCIENCE NEWS Mouse Stem Cell Study Offers New Insights into Body Fat Distribution New research shows that adding fat to mouse stem cells grown in the lab affects their response to the signals that push them to develop into one or other of the main types of fat storage cells – subcutaneous (under the skin) or visceral (around the organs). [UK National Stem Cell Network Press Release] New Cell Therapy Treatment for Osteoarthritis to be Trialled Cultured stem cells are to be used for the first time in the UK to treat the common joint condition of osteoarthritis, throwing a potential lifeline to millions of sufferers in the future. [Robert Jones and Agnes Hunt Orthopaedic Hospital in Oswestry Press Release]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) EphB-Ephrin-B2 Interactions are Required for Thymus Migration During Organogenesis Here, researchers show that, in the absence of ephrin-B2 expression on thymic neural crest-derived mesenchyme, the thymus remains in the cervical area instead of migrating into the thoracic cavity. [Proc Natl Acad Sci U S A] Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates To test the graft promoting effects of mesenchymal stem cells in a cynomolgus monkey model of islet/bone marrow transplantation. [Diabetes] Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage This soft PEG/CMP hydrogel shows promise as a biomimetic scaffold that provides a desirable environment for the chondrogenic differentiation of human mesenchymal stem cells and is useful for the repair of cartilage defects. [Biomaterials] The Effect of Incorporation of Exogenous Stromal Cell-Derived Factor-1 Alpha Within a Knitted Silk-Collagen Sponge Scaffold on Tendon Regeneration This study developed a bioactive knitted silk-collagen sponge scaffold by incorporation of exogenous SDF-1 alpha, to enable selective migration and homing of cells for in situ tendon regeneration. [Biomaterials] Characterizing Cancer Cells With Cancer Stem Cell-Like Features in 293T Human Embryonic Kidney Cells Here, researchers fully characterize cancer stem cell-like features in 293T human embryonic kidney cells. [Mol Cancer] Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis Cannabinoids are derivates of the marijuana component delta(9)-tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via CB1 and CB2 receptors. The aim of the present study was to evaluate the role of CB1 in systemic sclerosis. [Arthritis Rheum] Control of Fibroblast Fibronectin Expression and Alternative Splicing Via the PI3K/Akt/mTOR Pathway Here, researchers show TGF-beta, a potent inducer of both EDA (extra type III domain A) splicing and fibroblast activation, inhibits phosphatase and tensin homologue on chromosome 10 (PTEN) expression and activity in mesenchymal cells, corresponding with enhanced PI3K/Akt signaling. [Exp Cell Res] Identification of Growth and Attachment Factors for the Serum-Free Isolation and Expansion of Human Mesenchymal Stromal Cells Using classical approaches of medium development, researchers were able to identify a set of growth and attachment factors that allowed the serum-free isolation and expansion of human mesenchymal stromal cells from bone marrow. [Cytotherapy]
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POLICY NEWS Harold Varmus Sworn in as National Cancer Institute’s 14th Director Nobel Prize winner Harold E. Varmus, M.D., today took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States] Britain Delays Controversial Assessment Scheme for Research Britain’s new science minister made good a manifesto pledge today when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom] Spanish Science Spending Lockdown Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain] Maryland Stem Cell Research Commission Elects Margaret Conn Himelfarb as Chair The Maryland Stem Cell Research Commission announced that it has elected Margaret Conn Himelfarb as chair and Bowen P. Weisheit, Jr. as vice chair. [Maryland Stem Cell Research Commission, United States] Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting [Centers for Disease Control and Prevention, United States] Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States] Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States] National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States] Advisory Committee on Organ Transplantation; Notice of Meeting [National Institutes of Health, United States]
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EVENTS 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010 October 5-7, 2010 Hannover, Germany 2010 American Society for Matrix Biology (ASMB) Meeting October 24-27, 2010 Charleston, United States 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Senior Scientist – Magnetic Cell Separation (STEMCELL Technologies) Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Mesenchymal Cell News. Visit here to post your career opportunities.
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