SCIENCE NEWS Mayo’s “Smart” Adult Stem Cells Repair Hearts Mayo Clinic investigators, with Belgian collaborators, have demonstrated that rationally “guided” human adult stem cells can effectively heal, repair and regenerate damaged heart tissue. [Press release from Mayo Clinic discussing online prepublication in the Journal of the American College of Cardiology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Mesenchymal and Hematopoietic Stem Cells Form a Unique Bone Marrow Niche Here researchers demonstrated that mesenchymal stem cells, identified using nestin expression, constitute an essential hematopoietic stem cells niche component. [Nature] Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction The goal of this study was to guide bone marrow-derived human mesenchymal stem cells into a cardiac progenitor phenotype and assess therapeutic benefit in chronic myocardial infarction. [J Am Coll Cardiol] Bone Marrow-Derived Mesenchymal Cells and MMP13 Contribute to Experimental Choroidal Neovascularization In this study, investigators evaluated the potential involvement of collagenase-3 (MMP13), a matrix metalloproteinase family member, in the exudative form of age-related macular degeneration characterized by a neovascularisation into the choroid. [Cell Mol Life Sci] Down-Regulation of Thrombomodulin, a Novel Target of Snail, Induces Tumorigenesis Through Epithelial-Mesenchymal Transition The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently down-regulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown. Here, an inverse expression of TM and Snail was detected in different cancer cell lines. [Mol Cell Biol] Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Via Upregulation of Kruppel-Like Factor 2 This study shows that ultraviolet A inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells and its action mechanisms. [J Biol Chem] Effects of Microgravity Modeled by Large Gradient High Magnetic Field on the Osteogenic Initiation of Human Mesenchymal Stem Cells In the present study, scientists used large gradient high magnetic field (LGHMF) produced by a superconducting magnet to model microgravity (LGHMF-MG) and analyzed the effects of LGHMF-MG on survival, cytoskeleton and osteogenic potential of human mesenchymal stem cells. [Stem Cell Rev] Isolation of Cancer Stem Cells from Transformed Human Mesenchymal Stem Cell Line F6 In the present study, scientists isolated cancer stem cells from F6 cells based on CD133 expression using flow cytometry and investigated the biological characteristics of CD133+ F6 cells. [J Mol Med] Culture and Differentiation of Osteoblasts on Coral Scaffold from Human Bone Marrow Mesenchymal Stem Cells In this paper investigators described an approach that aims to provide fundamental information towards a scientific, biomechanical basis for the use of natural coral scaffolds to initiate mesenchymal stem cells into osteogenic differentiation for transplant purposes. [Cell Tissue Bank]
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POLICY NEWS EU Agency Allows Access to Drug Side Effects Data The European Medicines Agency has agreed to provide access to studies about drug side effects, following criticism over data secrecy from the European Ombudsman. [European Medicines Agency, European Union] Scientists Receive Nearly $11 Million to Develop Radiation Countermeasures Scientists at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $10.8 million grant to develop stem cell-based therapies that could be used to mitigate radiation-induced gastrointestinal syndrome – part of acute radiation syndrome – for military personnel, first responders and the general public. [National Institute of Allergy and Infectious Diseases, United States] Proposed Collection; Comment Request; NIH NCI Central Institutional Review Board (CIRB) Initiative (NCI) (FR Doc. 2010-20167) [National Institutes of Health, United States] Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010- 20023) [National Institutes of Health, United States] National Center for Research Resources; Notice of Meeting (FR Doc. 2010-20014) [National Institutes of Health, United States] 7342.007 Addendum – Imported Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) [Center for Biologics Evaluation and Research, United States] 7342.007 – Imported CBER-Regulated Products [Center for Biologics Evaluation and Research, United States] Complete List of Licensed Products and Establishments [Center for Biologics Evaluation and Research, United States] Comprehensive List of Guidance Documents at the Food and Drug Administration [Docket No. FDA-1998-N-0050] (formerly Docket No. 1998N-0046) [Food and Drug Administration, United States
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EVENTS (Listed by Date) Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine September 11-17, 2010 Hydra, Greece Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 5th Annual Germany Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany 2010 World Stem Cell Summit October 4-6, 2010 Detroit, United States 5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010 October 5-7, 2010 Hannover, Germany 17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.) October 6-9, 2010 Munich, Germany bone-tec 2010 – International Bone-Tissue Engineering Congress October 7-10, 2010 Hannover, Germany NEW The NYSCF Fifth Annual Translational Stem Cell Research Conference October 12-13, 2010 New York, United States International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference October 22-24, 2010 Dallas, United States 2010 American Society for Matrix Biology (ASMB) Meeting October 24-27, 2010 Charleston, United States Stem Cell Society Singapore Symposium 2010 November 2-3, 2010 Singapore 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8) January 21-26, 2011 Vancouver, Canada Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington DC, United States NEW Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States Stem Cells, Cancer and Metastasis (C4) March 6-11, 2011 Keystone, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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