Mesenchymal Cell News Volume 2.33 | Aug 24 2010

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    Mesenchymal Cell News 2.33, August 24, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing  
    Researchers describe the interplay between gingiva-derived mesenchymal stem cells and macrophages and the potential relevance in skin wound healing. [Stem Cells]

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    SCIENCE NEWS

    New Mechanisms of Tumor Resistance to Targeted Therapy in Lung Cancer are Discovered
    Researchers published results of a study that suggests new ways in which tumor cells develop resistance to one of the most successful targeted therapies, the small-molecule drug Tarceva (erlotinib). [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Proceedings of the National Academy of Sciences U.S.A]

    Defining Characteristics of Bona Fide Human iPS Cells
    Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
    G. Daley & T. Schlaeger Labs, Harvard Medical School
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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    TGF-Beta IL-6 Axis Mediates Selective and Adaptive Mechanisms of Resistance to Molecular Targeted Therapy in Lung Cancer
    In nonsmall cell lung cancer-derived cell lines and early-stage tumors before erlotinib treatment, researchers have uncovered the existence of a subpopulation of cells that are intrinsically resistant to erlotinib and display features suggestive of epithelial-to-mesenchymal transition. [Proc Natl Acad Sci USA]

    Core Epithelial-to-Mesenchymal Transition Interactome Gene-Expression Signature is Associated with Claudin-Low and Metaplastic Breast Cancer Subtypes
    The epithelial-to-mesenchymal transition core signature associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negatively with pathological complete response. [Proc Natl Acad Sci USA]

    Novel Hyperactive Transposons for Genetic Modification of Induced Puripotent and Adult Stem Cells: A Non-Viral Paradigm for Coaxed Differentiation
    Researchers demonstrate that hyperactive transposases derived from Sleeping Beauty resulted in superior gene transfer efficiencies and expression in mesenchymal and muscle stem/progenitor cells, consistent with higher expression levels of therapeutically relevant proteins including coagulation factor IX. [Stem Cells]

    Alpha2B-Adrenoceptor Deficiency Leads to Postnatal Respiratory Failure in Mice
    Alpha2B-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure. [J Biol Chem]

    Transplantation of Mesenchymal Stem Cells Exerts a Greater Long-Term Effect Than Bone Marrow Mononuclear Cells in a Chronic Myocardial Infarction Model in Rat
    The aim of this study is to assess the long-term effect of mesenchymal stem cells transplantation in a rat model of chronic myocardial infarction in comparison with the effect of bone marrow mononuclear cells transplant. [Cell Transplant]

    Tumor Associated Mesenchymal Stem Cells Protects Ovarian Cancer Cells from Hyperthermia through CXCL12
    Contrary to the previous published study, researchers demonstrated that TAMC and bone marrow-mesenchymal stem cells co-cultured with ovarian cancer cells induced thermotolerance in a CXCL12 dependant manner. [Int J Cancer]

    Dynamic Culture Enhances Stem Cell Infiltration and Modulates Extracellular Matrix Production on Aligned Electrospun Nanofibrous Scaffolds
    In this study, researchers demonstrated that a simple modification to standard in vitro culture conditions effectively improves cellular ingress into electrospun scaffolds, resolving a challenge which has until now limited the utility of these materials for various tissue engineering applications. [Acta Biomater]

    Osteogenic Differentiation of Human Mesenchymal Stem Cells Synergistically Enhanced by Biomimetic Peptide Amphiphiles Combined with Conditioned Media
    In this study, peptide amphiphiles were investigated as an extracellular matrix-mimicking biomaterial to provide an instructive microenvironment for human mesenchymal stem cells in an effort to guide osteogenic differentiation. [Acta Biomater]

    Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with Multiple Sclerosis: A Pilot Study
    Researchers explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells in 10 patients with advanced multiple sclerosis. [J Neuroimmunol]

    Rough Surface Topography Enhances the Activation of Wnt/Beta-Catenin Signaling in Mesenchymal Cells
    This study analyzed the behavior of the murine C2C12 mesenchymal cell line on polished or acid-etched, sand-blasted commercially pure titanium. [J Biomed Mater Res A]

    INDUSTRY NEWS

    Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
    The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

    NSF Awards $3 Million Stem Cell Bio-Manufacturing Program to Georgia Tech
    The National Science Foundation (NSF) has awarded $3 million to the Georgia Institute of Technology to fund a unique research program on stem cell bio-manufacturing. [Georgia Institute of Technology Press Release]

    Mesoblast On Track for Phase III Bone Marrow Transplant Trial Following Positive Meeting with FDA
    Mesoblast Limited provided market guidance on its Phase III bone marrow transplant program following a formal meeting with the United States Food and Drug Administration (FDA). [Mesoblast Limited Press Release]

    Sanofi Seeks Efficiencies with New Model
    Sanofi-aventis is dividing its vast resources into decentralized disease-based units, each with its own departments for research and development, regulatory affairs, marketing, and sales — a plan designed to identify promising drugs more quickly and weed out failures before spending billions on unsuccessful clinical trials. [The Boston Globe]

    POLICY NEWS

    Lawrence A. Tabak Named Principal Deputy Director NIH
    National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]

    FDA, Companies Must Stretch Overseas Supply Oversight
    The FDA is trying to stretch its enforcement reach over foreign drug suppliers, potentially through consent decrees, and is asking manufacturers to take bigger steps as well to tighten the pharmaceutical supply chain. [Food and Drug Administration, United States]

    Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States]

    Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-20287) [National Institutes of Health, United States]

    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]

    NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States]

    Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]

    EVENTS (Listed by Date)

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
    September 11-17, 2010
    Hydra, Greece

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States   

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
    September 15-17, 2010
    Sydney, Australia

    5th Annual Germany Society for Stem Cell Research
    September 30-October 2, 2010
    Lübeck, Germany

    2010 World Stem Cell Summit
    October 4-6, 2010
    Detroit, United States

    5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
    October 5-7, 2010
    Hannover, Germany

    17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
    October 6-9, 2010
    Munich, Germany

    bone-tec 2010 – International Bone-Tissue Engineering Congress
    October 7-10, 2010
    Hannover, Germany

    The NYSCF Fifth Annual Translational Stem Cell Research Conference
    October 12-13, 2010
    New York, United States

    International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
    October 22-24, 2010
    Dallas, United States

    2010 American Society for Matrix Biology (ASMB) Meeting
    October 24-27, 2010
    Charleston, United States

    Stem Cell Society Singapore Symposium 2010
    November 2-3, 2010
    Singapore

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
    December 5-8, 2010
    Orlando, United States

    Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
    January 21-26, 2011
    Vancouver, Canada

    Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
    January 24-26, 2011
    Washington DC, United States

    Stem Cells in Development, Tissue Homeostasis and Disease
    January 30-February 4, 2011
    Santa Fe, United States

    Stem Cells, Cancer and Metastasis (C4)
    March 6-11, 2011
    Keystone, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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