SCIENCE NEWS How Physical Environment Influences Stem Cell Development Recent research has revealed how physical qualities — and not only chemical ones — may have an influence in determining how adult stem cells from the bone marrow develop into differentiated ones. [Press release from ScienceDaily discussing online prepublication in Nature Physics] New Evidence that Fat Cells Are not Just Dormant Storage Depots for Calories Scientists are reporting new evidence that the fat tissue in those spare tires and lower belly pooches — far from being a dormant storage depot for surplus calories — is an active organ that sends chemical signals to other parts of the body, perhaps increasing the risk of heart attacks, cancer, and other diseases. [Press release from the American Chemical Society discussing online prepublication in the Journal of Proteome Research]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Puma is Required for p53-Induced Depletion of Adult Stem Cells To investigate the roles of DNA damage and p53 in tissue-regenerative capability, two phosphorylation-site mutations (T21D and S23D) were introduced into the endogenous p53 gene in mice, so that the synthesized protein mimics phosphorylated p53. [Nat Cell Biol] Optimal Matrix Rigidity for Stress-Fiber Polarization in Stem Cells The findings offer physical insight into the sensitivity of stem cell differentiation to tissue elasticity and, more generally, introduce a cell-type-specific parameter for actomyosin polarizability. [Nat Phys] Tuberin Regulates E-Cadherin Localization – Implications in Epithelial-Mesenchymal Transition In this study, researchers show that tuberin regulates the localization of E-cadherin via an Akt/mTORC1/CLIP170-dependent, rapamycin-sensitive pathway. Consequently, Tsc2(-/-) epithelial cells display a loss of plasma membrane E-cadherin that leads to reduced cell-cell adhesion. [Am J Pathol] Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells It can be concluded that Simpson Golabi Behmel syndrome (SGBS) cells are both a valid human cell model for adipocyte secretion profiling and for searching for novel human (pre)adipocytes secreted proteins. [J Proteome Res] New Strategies for Anterior Cruciate Ligament Partial Rupture Using Bone Marrow Transplantation in Rats The purpose of this study was to compare anterior cruciate ligament regeneration between animal groups subjected to intra-articular injection of fresh whole bone marrow cells, cultured mesenchymal stem cells or saline. [Stem Cells Dev] Hypoxia and Amino Acid Supplementation Synergistically Promote the Osteogenesis of Human Mesenchymal Stem Cells on Silk Protein Scaffolds Silk protein scaffolds seeded with human mesenchymal stem cells in osteogenic differentiation media were used to study in vitro osteogenesis under varied conditions of amino acid (lysine and proline) concentration and oxygen level. [Tissue Eng Part A] The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study The goal of this study was to evaluate the effect of simulated microgravity on all genes expressed in human mesenchymal stem cells, with the underlying hypothesis that many important pathways are affected during culture within a rotating wall vessel system. [Tissue Eng Part A] Improved Proliferation and Differentiation Capacity of Human Mesenchymal Stromal Cells Cultured with Basement-Membrane Extracellular Matrix Proteins The results suggest that expansion of bone marrow-derived mesenchymal stromal cells (MSC) in the presence of extracellular matrix proteins is a powerful approach for generating large numbers of MSC, showing a prolonged capacity to differentiate into mesodermal cell lineages, with the exception of the lack of chondrogenesis by using laminin-5 coating. [Cytotherapy]
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POLICY NEWS NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States] Obama Administration Appeals Stem Cell Injunction The Obama administration asked a federal judge on to lift an injunction halting human embryonic stem cell research, saying it would irreparably harm research and cost more than 1,300 jobs. [The White House, United States] NIH Asks Judge to Suspend Stem Cell Research Injunction Warning of a “devastating impact” on ongoing research, the National Institutes of Health (NIH) asked a federal court to stay a preliminary injunction that last week forced NIH to suspend future grant payments to study human embryonic stem cells (hESC) and shut down its in-house research on hESCs. [National Institutes of Health, United States] Judge Upholds Stem Cell Funding Ban A Washington, D.C., judge said this afternoon that his ruling two weeks ago, halting all federal funding for human embryonic stem cell research, will stand while the case moves forward. Chief Judge Royce Lamberth, responding to a request from the Department of Justice that he stay his preliminary injunction, released a 3-page order denying the request. [United States District Court for the District of Columbia] Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States] Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States] Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States] Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States] Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]
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EVENTS (Listed by Date) International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine September 11-17, 2010 Hydra, Greece Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 5th Annual Germany Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany 2010 World Stem Cell Summit October 4-6, 2010 Detroit, United States 5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010 October 5-7, 2010 Hannover, Germany 17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.) October 6-9, 2010 Munich, Germany bone-tec 2010 – International Bone-Tissue Engineering Congress October 7-10, 2010 Hannover, Germany The NYSCF Fifth Annual Translational Stem Cell Research Conference October 12-13, 2010 New York, United States International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference October 22-24, 2010 Dallas, United States 2010 American Society for Matrix Biology (ASMB) Meeting October 24-27, 2010 Charleston, United States Stem Cell Society Singapore Symposium 2010 November 2-3, 2010 Singapore 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8) January 21-26, 2011 Vancouver, Canada Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington DC, United States Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States Stem Cells, Cancer and Metastasis (C4) March 6-11, 2011 Keystone, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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