SCIENCE NEWS Stem Cell Transplant May Help MS, ALS Patients Patients with multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) who received mesenchymal stromal cell transplantation in a recent Phase I/II trial experienced stabilization and, in some cases, improvement. [Press release from The Cleveland Clinic discussing online prepublication in the Archives of Neurology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement Researchers report here that epithelial-to-mesenchymal transition induced through ectopic expression of Twist or Snail promotes alpha-tubulin detyrosination and the formation of tubulin-based microtentacles in detached HMLEs. [Cancer Res] The Osteogenic Differentiation of Human Osteoprogenitor Cells on Anodic-Plasma-Chemical Treated Ti6Al7Nb In the present study, researchers compared the potential of anodic plasma-chemical surface treatment of high-strength titanium alloys with vacuum plasma spray treatment and yellow gold anodization in supporting osteogenic differentiation of two different osteoprogenitor cell types. [Biomaterials] The Spreading, Migration and Proliferation of Mouse Mesenchymal Stem Cells Cultured Inside Hyaluronic Acid Hydrogels In this study, researchers synthesized hyaluronic acid hydrogels that could be degraded through a combination of cell-released enzymes and used them to culture mouse mesenchymal stem cells. [Biomaterials] Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis The objective of this study was to evaluate the feasibility, safety, and immunological effects of intrathecal and intravenous administration of autologous mesenchymal stem cells in patients with multiple sclerosis and amyotrophic lateral sclerosis. [Arch Neurol] Relevance of the Mevalonate Biosynthetic Pathway in the Regulation of Bone Marrow Mesenchymal Stromal Cell-Mediated Effects on T Cell Proliferation and B Cell Survival Bone marrow mesenchymal stromal cells can suppress T lymphocyte proliferation, but promote survival of normal and malignant B cells, thus representing a possible target for new therapeutic schemes. Herein, researchers defined the effects of cholesterol synthesis inhibitors on the interaction between these mesenchymal stromal cells and T or B lymphocytes. [Haematologica] Human Cardiac and Bone Marrow Stromal Cells Exhibit Distinctive Properties Related to Their Origin The objective of the present work was the comparison of in vitro and in vivo properties of adult human cardiac stromal cells to those of syngeneic bone marrow mesenchymal stromal cells. [Cardiovasc Res] Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Upregulate Myelin Basic Protein in Shiverer Mice In the present study, researchers aimed to investigate the potential of human umbilical cord blood-derived pluripotent mesenchymal stem cells to myelinate the axons of shiverer mice brains. [Stem Cells Dev] Effect of the Modulation of Leucine Zipper Tumor Suppressor 2 Expression on Proliferation of Various Cancer Cells Functions as a Tumor Suppressor Researchers showed that NF-kappaB-induced modulation of beta-catenin/Tcf pathway is regulated by leucine zipper tumor suppressor 2 (lzts2) expression in mesenchymal stem cells and several cancer cells, and that NF-kappaB-induced lzts2 expression is differentially regulated among cancer cell types. [Mol Cell Biochem]
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POLICY NEWS NIH Announces New Program to Accelerate Research Independence The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States] NIH Launches Genotype-Tissue Expression Project The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States] FDA’s $25 Million Pitch for Improving Drug Regulation The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States] FDA to Push for More Investment in Science Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States] FDA Issues Regulatory Science Report The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States] Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176) [National Institutes of Health, United States] National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-25172) [National Institutes of Health, United States]
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EVENTS (Listed by Date) The American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting October 15-19, 2010 Toronto, Canada Stem Cells and Regenerative Medicine – New Solutions to Old Problems October 18-20, 2010 San Antonio, United States International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference October 22-24, 2010 Dallas, United States American Society for Matrix Biology (ASMB) 2010 Biennial Meeting October 24-27, 2010 Charleston, United States 2nd Annual Stem Cells Asia and Regenerative Medicine Congress October 26-28, 2010 Seoul, Korea FDA Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations November 2, 2010 North Bethesda, United States Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy November 2-3, 2010 Singapore 6th National Cancer Research Institute (NCRI) Conference November 7-10, 2010 Liverpool, United Kingdom 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC) November 12-13, 2010 Tianjin, China The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms November 15-18, 2010 Nara, Japan 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development November 18-19, 2010 Lattrop, The Netherlands Stem Cell Network’s 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Alberta First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium December 1-3, 2010 Berlin, Germany 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference December 5-8, 2010 Orlando, United States The American Society for Cell Biology 50th Annual Meeting December 11-15, 2010 Philadelphia, United States Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada Select Biosciences 5th Annual Stem Cells World Congress January 24-25, 2011 San Diego, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, DC, United States Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Stem Cells, Cancer and Metastasis (C4) March 6-11, 2011 Dillon, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference June 7-10, 2011 Granada, Spain International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011) August 3-5, 2011 Singapore Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Clean Room Team Leader – Cellular Therapy (Cell Medica Limited) Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Mesenchymal Cell News at no cost. Visit here to post your career opportunities.
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