Mesenchymal Cell News Volume 2.43 | Nov 2 2010

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    Mesenchymal Cell News 2.43, November 2, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Novel Hyperactive Transposons for Genetic Modification of Induced Pluripotent and Adult Stem Cells: A Nonviral Paradigm for Coaxed Differentiation 
    Researchers have previously generated hyperactive transposases derived from Sleeping Beauty, using an in vitro molecular evolution and selection paradigm. They now demonstrate that these hyperactive transposases resulted in superior gene transfer efficiencies and expression in mesenchymal and muscle stem/progenitor cells, consistent with higher expression levels of therapeutically relevant proteins including coagulation factor IX. [Stem Cells]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing
    The findings provide first evidence that mesenchymal stem cells from human gingiva are capable to elicit M2 polarization of macrophages, which might contribute to a marked acceleration of wound healing. [Stem Cells]

    Antibacterial Effect of Human Mesenchymal Stem Cells is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37
    Researchers studied the effect of human mesenchymal stem cells (MSC) derived from bone marrow on the bacterial growth of gram-negative (E. coli and P. aeruginosa) and gram-positive (S. aureus ) bacteria. MSC as well as their conditioned medium demonstrated marked inhibition of bacterial growth in comparison to control medium or normal human lung fibroblasts. [Stem Cells]

    Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells Through p38 MAPK Pathway
    The results showed that gold nanoparticles promoted the differentiation of mesenchymal stem cells toward osteoblast cells over adipocyte cells by inducing an enhanced osteogenic transcriptional profile and an attenuated adipogenic transcriptional profile. [ACS Nano]

    Role of Canonical Wnt Signaling/Beta-Catenin via Dermo1 in Cranial Dermal Cell Development
    Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, researchers show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. [Development]

    Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation
    In this paper, researchers report that suppression of mitogen-induced T cell proliferation by human umbilical cord-, bone marrow-, and cord blood-mesenchymal stromal cells required monocytes. [J Immunol]

    ARTEMIS Stabilizes the Genome and Modulates Proliferative Responses in Multipotent Mesenchymal Cells
    Here, researchers investigate roles for the nonhomologous end joining factor ARTEMIS in multipotent mesenchymal stem/progenitor cells, as putative sarcomagenic cells of origin. [BMC Biol]

    Transient Expression of OCT4 is Sufficient to Allow Human Keratinocytes to Change Their Differentiation Pathway
    Researchers transiently transfected freshly isolated human skin keratinocytes with the single transcription factor OCT4. Within two days these cells displayed expression of endogenous embryonic genes and showed reduced genomic methylation. More importantly, these cells could be specifically converted into neuronal and contractile mesenchymal cell types. [Gene Ther]

    Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State
    Human mesenchymal stem cells (hMSCs) are therapeutically useful cells that are typically expanded in vitro on stiff substrata before reimplantation. Here, researchers explore MSC mechanical and structural changes via atomic force microscopy and optical stretching during extended passaging, and demonstrate that cytoskeletal organization and mechanical stiffness of attached MSC populations are strongly modulated over >15 population doublings in vitro. [Biophys J]

    Amniotic Mesenchymal Stem Cells Enhance Normal Fetal Wound Healing
    Researchers conclude that fetal wound healing encompasses an autologous yet exogenous cellular component in naturally occurring amniotic mesenchymal stem cells. While seemingly not absolutely essential to the healing process, amniotic cells expedite wound closure and enhance its extracellular matrix profile. [Stem Cells Dev]

    Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
    Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for STRO1, OCT3/4 and SSEA-4 as well as the classic MSC-markers CD44, CD73, CD90, Ki67, CD105 and CD106 and negative for CD34 and CD45. [Stem Cells Dev]

    Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Grow Best Under GMP-Compliant Culture Conditions and Maintain Their Phenotypic and Functional Properties
    Here, researchers analyzed the phenotypic and functional properties of umbilical cord mesenchymal stem cells (UCMSC) under xeno-free (XF, containing GMP-certified human serum) and serum-free culture conditions in comparison with standard UCMSC cultures. [J Immunol Methods]


    INDUSTRY NEWS

    Stem Cell Central: The Lorry I. Lokey Building
    The Lokey Building, an incredible new laboratory facility, is built on a design championed by faculty to facilitate research in one of the most exciting interdisciplinary areas of the 21st century – stem cell biology and regenerative medicine. [Stanford University School of Medicine Press Release]

    Cytori to Webcast Third Quarter Financial Results
    Cytori Therapeutics will host a webcast to discuss their third quarter financial results. [The Wall Street Journal]


    POLICY NEWS

    NIH Introduces Images, a Database of Images in Biomedical Literature
    More than 2.5 million images and figures from medical and life sciences journals are now available through Images, a new resource for finding images in biomedical literature. [National Institutes of Health, United States]

    NIH Recovery Act Grants to Foster Scientific Workforce Diversity
    The National Institutes of Health has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]

    Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

    National Heart, Lung, and Blood Institute; Notice of Closed Meetings (FR Doc. 2010-27319) [National Institutes of Health, United States]

    National Heart, Lung, and Blood Institute; Notice of Meetings (FR Doc. 2010-27318) [National Institutes of Health, United States]

    National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-26889) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27325) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-27410) [National Institutes of Health, United States]

    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    National Cancer Research Institute (NCRI) Conference 2010
    November 7-10, 2010
    Liverpool, United Kingdom

    9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
    November 7-10, 2010
    Philadelphia, United States

    Third Annual Research Experience of Stem Cells in European Society (RESCUES) Conference
    November 8-9, 2010
    Oxford, United Kingdom

    Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
    November 12-13, 2010
    Tianjin, China

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
    November 16-19, 2010
    Berlin, Germany

    Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
    November 18-19, 2010
    Lattrop, The Netherlands

    Stem Cell Network’s 10th Annual Scientific Meeting
    November 22-24, 2010
    Calgary, Canada

    First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
    December 1-3, 2010
    Berlin, Germany

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
    December 5-8, 2010
    Orlando, United States

    5th Annual Stem Cell Meeting on the Mesa
    December 7, 2010
    La Jolla, United States

    The American Society for Cell Biology 50th Annual Meeting
    December 11-15, 2010
    Philadelphia, United States

    Pharmacology in Stem Cells Research and Regenerative Medicine
    December 17, 2010
    London, United Kingdom

    Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
    January 21-26, 2011
    Vancouver, Canada

    5th Annual Stem Cells and Regenerative Medicine World Congress
    January 24-25, 2011
    San Diego, United States

    Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
    January 24-26, 2011
    Washington, D.C., United States

    Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
    January 30-February 4, 2011
    Santa Fe, United States

    1st Annual Clinical Meeting of the Cell Society
    February 18-19, 2011
    La Jolla, United States

    NEW  6th Annual Stem Cell Summit
    March 1, 2011
    New York, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    Stem Cells, Cancer and Metastasis (C4)
    March 6-11, 2011
    Dillon, United States

    United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
    March 30-April 1, 2011
    York, United Kingdom

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
    June 7-10, 2011
    Granada, Spain

    International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
    June 15-18, 2011
    Toronto, Canada

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
    August 3-5, 2011
    Singapore

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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