CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects Because mesenchymal stem cells (MSCs) reside in low oxygen niches in vivo, researchers propose that, in Hutchinson-Gilford Progeria syndrome, this causes additional depletion of the MSC pool responsible for replacing differentiated cells lost to progerin toxicity. [Cell Stem Cell] Hypoxia-Inducible Vascular Endothelial Growth Factor-Engineered Mesenchymal Stem Cells Prevent Myocardial Ischemic Injury In an effort to reduce ischemic myocardial damage, researchers investigated the effects on infarcted myocardium of transplantation of genetically modified mesenchymal stem cells (MSCs) that specifically expressed vascular endothelial growth factor (VEGF) under hypoxic conditions. [Mol Ther] MITR is a Switch that Promotes Osteogenesis and Inhibits Adipogenesis of Mesenchymal Stem Cells by Inactivating PPAR(gamma)-2 Results demonstrated that MITR plays a master switch role to balance osteogenic and adipogenic differentiation of mesenchymal stem cells through regulation of PPAR(gamma)-2 transcriptional activity. [J Biol Chem] Dynamic Tensile Loading Improves the Functional Properties of MSC-Laden Nanofiber-Based Fibrocartilage The results show that dynamic tensile loading enhances the maturation of mesenchymal stem cell (MSC)-laden aligned nanofibrous constructs, suggesting that recapitulation of the structural and mechanical environment of load-bearing tissues results in increases in functional properties which can be exploited for tissue engineering applications. [Tissue Eng Part A] Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation Previous studies showed that co-culture of primary chondrocytes with various sources of multipotent cells results in a higher relative amount of cartilage matrix formation than cultures containing only chondrocytes. The aim of this study is to investigate the mechanism underlying this observation. [Tissue Eng Part A] Mesenchymal Stem Cell Characteristics of Human Anterior Cruciate Ligament Outgrowth Cells When ruptured, the anterior cruciate ligament (ACL) of the human knee has limited regenerative potential. However, the goal of this report was to show, that the cells that migrate out of the human ACL constitute a rich population of progenitor cells and researchers hypothesize that they display mesenchymal stem cell (MSC) characteristics when compared with adherent cells derived from bone marrow or collagenase digests from ACL. [Tissue Eng Part A] In Vitro Assessment of the Differentiation Potential of BMSCs on Genipin-Chitosan Conjugation Scaffold with Surface Hydroxyapatite Nanostructure for Bone Tissue Engineering In this study, researchers examined the effect of surface biomimetic apatite nanostructure of a new hydroxyapatite coated genipin-chitosan conjugation scaffold on cell shape, cytoskeleton organization and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. [Tissue Eng Part A] Effects of Nanofiber/Stem Cell Composite on Wound Healing in Acute Full-Thickness Skin Wounds Acute full-thickness skin wounds (FTSW) caused by extensive burns or high energy trauma are not adequately addressed by current clinical treatments. This study hypothesized that biomimetic nanofiber scaffolds (NFS) functionalized with rich attachment of bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute FTSW. [Tissue Eng Part A] Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants Researchers aim to overcome mesenchymal stem cell (MSC) immune rejection through permanent down-regulation of major histocompatibility complex (MHC) class I proteins on the surface of these MHC class II-negative cells through the use of viral immune evasion proteins. [PLoS ONE]
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