Mesenchymal Cell News Volume 3.12 | Mar 29 2011

Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Towards a Progenitor-Like State through Partial Cell Fusion and Mitochondria Transfer
To further characterize cell fusion, researchers co-cultured mouse fully differentiated cardiomyocytes with human multipotent adipose-derived stem cells as a model of adult stem cells. [Stem Cells]

Erythropoietin Couples Erythropoiesis, B Lymphopoiesis, and Bone Homeostasis Within the Bone Marrow Microenvironment
Using in vivo lineage tracing researchers document that within the hematopoietic and mesenchymal lineage, expression of Epo-R is essentially restricted to erythroid lineage cells. [Blood]

Differentiation Potential of Human Postnatal MSC, MAB and MAPC Reflected in their Transcriptome and Partially Influenced by the Culture Conditions
Researchers compared the phenotype and functional characteristics of human Mesenchymal Stem Cells (hMSC), Mesoangioblasts (hMab) and Multipotent Adult Progenitor Cells (hMAPC) using uniform standardized methods. [Stem Cells]

Mesenchymal Stem Cell Migration is Regulated by Fibronectin through a5ß1-Integrin-Mediated Activation of PDGFR-ß and Potentiation of Growth Factor Signals
Here, researchers report extracellular matrix-directed crosstalk between platelet-derived growth factor receptor (PDGFR)-ß and a5ß1-integrin, which controls the migration of mesenchymal stem (stromal) cells. [J Cell Sci]

Chromosomal Variability of Human Mesenchymal Stem Cells Cultured under Hypoxic Conditions
Researchers propose that the continuous monitoring of human mesenchymal stem cells (hMSCs) will be required before they are used in therapeutic applications in the clinic, especially when cells are cultured under hypoxic conditions. [J Cell Mol Med]

Expression of Blood Group Genes by Mesenchymal Stem Cells
Focusing on distinct carbohydrate- and protein-based membrane structures, defined by blood group antigens, researchers investigated human bone marrow-derived mesenchymal stem cells (MSCs) cultured in human serum. [Br J Haematol]

Metabolic Activities and Chondrogenic Differentiation of Human Mesenchymal Stem Cells Following rAAV-Mediated Gene Transfer and Overexpression of Fibroblast Growth Factor 2
Here, researchers examined the effects of rAAV-mediated overexpression of human FGF-2, a mitogenic factor also known to influence mesenchymal stem cell (MSC) differentiation, upon the proliferative and chondrogenic activities of human MSCs in a three-dimensional environment that supports chondrogenesis in vitro. [Tissue Eng Part A]

Human Embryonic Stem Cell-derived Mesenchymal Stem Cells (MSCs) as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma
Mesenchymal stem cell potential in cancer therapy highlights the need for a consistent and renewable source for the production of uniform human MSCs suitable for clinical applications. In this study, researchers seek to investigate whether human embryonic stem cells can be used as a cell source to fulfill this goal. [Hum Gene Ther]

Variable Behavior of Autologous Bone Marrow Mesenchymal Stem Cells Transplanted in Experimental Autoimmune Encephalomyelitis (EAE)
In the current study, bone marrow stromal cells (BMSCs) were intracerebroventricular administered in severe and mild EAE, as well as naive animals; Neural Precursor Cells served as cellular controls. [Exp Neurol]

Genetically Modified Adipose Tissue Derived Mesenchymal Stem Cells (AT-MSC) Overexpressing CXCR4 Display Increased Motility, Invasiveness and Homing to Bone Marrow of NOD/SCID Mice
This study evaluates usefulness of CXCR4 overexpression, via retroviral transduction, in adipose tissue derived MSC, as a strategy to increase their migration and engraftment ability. [Exp Hematol]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW The EMBO Meeting: Advancing the Life Sciences
September 10-13, 2011
Vienna, Austria

Visit our events page to see a complete list of events in the mesenchymal cell community.

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Field Applications Specialist – Cell Therapy (Pall Corporation) 

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

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