Intravenous Administration of Auto Serum-Expanded Autologous Mesenchymal Stem Cells in Stroke Researchers report a study designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells expanded in autologous human serum in stroke patients. [Brain] The Use of Dynamic Surface Chemistries to Control MSC Isolation and Function This paper defines the potential of –CH3 modified surfaces, with optimized dynamic surface chemistry, to manipulate initial mesenchymal stem cell (MSC) adhesive events, integrin binding, and subsequent cell function. [Biomaterials] Simultaneous Regeneration of Articular Cartilage and Subchondral Bone In Vivo Using MSCs Induced by a Spatially Controlled Gene Delivery System in Bilayered Integrated Scaffolds In the present study, researchers formulated a bilayered gene-activated osteochondral scaffold consisting of plasmid TGF-ß1-activated chitosan-gelatin scaffold for chondrogenic layer and plasmid BMP-2-activated hydroxyapatite/chitosan-gelatin scaffold for osteogenic layer. [Biomaterials] Relative Percentage and Zonal Distribution of Mesenchymal Progenitor Cells in Human Osteoarthritic and Normal Cartilage The present results underline the suitability of CD166 as a biomarker to identify and, in particular, localize and/or enrich resident mesenchymal progenitor cells with a high chondrogenic potential in human articular cartilage. [Arthritis Res Ther] Fetal Liver-Derived Mesenchymal Stem Cell Engraftment After Allogeneic In Utero Transplantation into Rabbits Researchers report safe and widespread distribution of recombinant pSF-EGFP retrovirus-transduced fetal rabbit liver mesenchymal stem cells in neonatal rabbit tissues at 10 days after fetal allogeneic transplantation through both intrahepatic and intra-amniotic administration. [Stem Cells Dev] Adipogenic Differentiation of Individual Mesenchymal Stem Cell on Different Geometric Micropatterns Human mesenchymal stem cells were cultured on the micropatterned surface, and the effect of cell geometry on adipogenic differentiation was investigated. [Langmuir] Effective Treatment of Severe Steroid-Resistant Acute Graft-Versus-Host Disease with Umbilical Cord-Derived Mesenchymal Stem Cells Researchers compared umbilical cord-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells for morphology, surface markers expression, differentiation, proliferative potential, and their suppressive effects on peripheral blood mononuclear cell proliferation. [Transplantation] Mixture of Fibroblasts and Adipose Tissue-Derived Stem Cells Can Improve Epidermal Morphogenesis of Tissue-Engineered Skin The findings revealed for the first time that a mixture of fibroblasts and adipose tissue-derived stem cells in bilayered tissue-engineered skin can improve epidermal morphogenesis. [Cells Tissues Organs] Multipotent Mesenchymal Stromal Cells Express FoxP3: A Marker for the Immunosuppressive Capacity? Regulatory T lymphocytes and mesenchymal stromal cells have immunosuppressive features in common. Here, researchers looked for a common basis for immunosuppression in these distinct cell types. [J Immunother] Investigating the Role of Hematopoietic Stem and Progenitor Cells in Regulating the Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro In this study, researchers investigated the influence of hematopoietic stem and progenitor cells on the osteogenic differentiation of mesenchymal stem cells in vitro, using a highly enriched population of hematopoietic cells with the phenotype c-Kit+Sca-1+Lineage- and bone marrow derived mesenchymal stromal cells in direct contact co-culture in medium with or without the addition of the osteogenic supplement dexamethasone. [J Orthop Res] |