Dissection of the Biphasic Nature of Hypoxia-Induced Motogenic Action in Bone Marrow-Derived Human Mesenchymal Stem Cells In this study, designed to dissect mechanisms underlying hypoxia-dependent migration of bone marrow-derived human mesenchymal stem cells, signal transduction and molecular mechanisms were evaluated by integrating morphological, molecular and cell biology techniques, including the wound healing and modified Boyden’s chamber assays to monitor migration. [Stem Cells] TLR-3-Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils In this study, researchers aimed to assess whether Toll-like receptor (TLR)3- and TLR4-activated bone marrow-derived mesenchymal stromal cells influence human neutrophil responses under coculture conditions. [Stem Cells] Adipose Tissue-Derived Stem Cell In Vitro Differentiation in a Three-Dimensional Dental Bud Structure Researchers show how mesenchyme-derived single stem cell populations can be induced to transdifferentiate in vitro in a structure similar to a dental bud. [Am J Pathol] Adipose Injury–Associated Factors Mitigate Hypoxia in Ischemic Tissues through Activation of Adipose-Derived Stem/Progenitor/Stromal Cells and Induction of Angiogenesis The results suggest that adipose injury cocktail may have therapeutic potentials for various ischemic/hypoxic conditions by inducing adipose remodeling and neovascularization through activation of adipose-derived stem/progenitor/stromal cells and other cells. [Am J Pathol] Contamination of Mesenchymal Stem-Cells with Fibroblasts Accelerates Neurodegeneration in an Experimental Model of Parkinson’s Disease Here researchers show for the first time, using the same experimental model and protocol, that transplantation of umbilical cord-derived mesenchymal stem cells induced potent neuroprotection in the brain resulting in clinical benefit. [Stem Cell Rev] Aligned Hybrid Silk Scaffold for Enhanced Differentiation of Mesenchymal Stem Cells into Ligament Fibroblasts The results show that the aligned hybrid scaffold system is promising for enhancing cell proliferation, differentiation, and function for ligament tissue engineering applications. [Tissue Eng Part C Methods] Isolation and Characterization of Mesenchymal Stem Cells (MSCs) from the Fat Layer on the Density Gradient Separated Bone Marrow In the present study researchers presented evidences that MSCs could be isolated from the very low-density cells of the fat layer. [Stem Cells Dev] Chemokines Stimulate Bi-Directional Migration of Human Mesenchymal Stem Cells Across Bone Marrow Endothelial Cells Here researchers describe the migratory cues that drive mesenchymal stem cell transendothelial migration in both directions with focus on chemokines. [Stem Cells Dev] PDX1- and NGN3-Mediated In Vitro Reprogramming of Human Bone Marrow-Derived Mesenchymal Stromal Cells (BM-MSC) into Pancreatic Endocrine Lineages Reprogramming primary BM-MSC into pancreatic endocrine lineages has not yet been consistently demonstrated. To unravel the role and interaction of key factors governing this process, researchers used well-characterized telomerase-immortalized human MSC (hMSC-TERT). [Cytotherapy] |