Mesenchymal Cell News Volume 3.21 | May 31 2011

Fgf2 Inhibits Differentiation of Mesenchymal Stem Cells by Inducing Twist2 Spry4, Blocking Extracellular Regulated Kinase Activation and Altering Fgfr Expression Levels
The results demonstrate that inhibition of mouse mesenchymal stem cell differentiation by Fgf2 is strongly correlated with up regulation of Twist2 and Spry4 and suppression of Erk1/2 activation. [Stem Cells]

Autologous Bone Mesenchymal Stem Cell Transplantation in Liver Failure Patients Caused by Hepatitis B: Short-Term and Long-Term Outcomes
The study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells. [Hepatology] 

Mesenchymal Stem Cell (MSC) Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer
This study aimed to introduce MSC-mediated expression of the sodium iodide symporter for imaging and therapy of breast cancer. [Stem Cells]

Inhibition of Osteogenic Differentiation of Human Adipose Derived Stromal Cells by RBP2 Repression of RUNX2-activated Transcription
In this study, the roles of retinoblastoma binding protein 2 (RBP2) in osteogenic differentiation of human adipose-derived stromal cells were investigated. [Stem Cells]

Electrically Conductive Gold-Coated Collagen Nanofibers for Placental-Derived Mesenchymal Stem Cells Enhanced Differentiation and Proliferation
Gold-coated collagen nanofibers were produced by a single-step reduction process and used for the growth and differentiation of human adult stem cells. The nanomaterials were characterized by a number of analytical techniques including electron microscopy and spectroscopy. [ACS Nano]

Engineering of Large Osteogenic Grafts with Rapid Engraftment Capacity Using Mesenchymal and Endothelial Progenitors from Human Adipose Tissue
Researchers investigated whether the maintenance in culture of endothelial and mesenchymal progenitors from the stromal vascular fraction of human adipose tissue supports the formation of vascular structures in vitro and thereby improves the efficiency and uniformity of bone tissue formation in vivo within critically sized scaffolds. [Biomaterials]

Label-Free Protein Profiling of Adipose-Derived Human Stem Cells under Hyperosmotic Treatment
Here, researchers used label-free proteomic profiling to evaluate the effects of control and hyperosmotic treatment environments on the phenotype of multipotent adipose-derived stem cells cultivated with a chondrogenic growth factor cocktail. [J Proteome Res]

Mitochondrial Function and Energy Metabolism in Umbilical Cord Blood – and Bone Marrow-Derived Mesenchymal Stem Cells
The present work focuses on the mitochondrial function of human mesenchymal stem cells from umbilical cord blood, bone marrow cells from donors under 18 years old (BMMSC<18) and over 50 years old (BMMSC>50). [Stem Cells Dev]

Identification of Mesenchymal Stem Cells in Perinodular Fat and Skin in Dupuytren’s Disease: A Potential Source of Myofibroblasts with Implications for Pathogenesis and Therapy
The aim of this study was to profile mesenchymal stem cells from phenotypically distinct Dupuytren’s disease sites including cord, nodule, skin overlying nodule and peri-nodular fat compared to unaffected internal controls i.e., distant palmar fat and transverse palmar fas-cia (Skoog’s fibers) as well as external control carpal tunnel tissue including skin, fat and fascia. [Stem Cells Dev]

Bone Marrow Cells Repair Cigarette Smoke-Induced Emphysema in Rats
Scientists tested the capacities of bone marrow cells, mesenchymal stem cells (MSCs), and conditioned media of MSCs (MSC-CM) to repair cigarette smoke-induced emphysema. [Am J Physiol Lung Cell Mol Physiol]

Retinoic Acid-Induced Smad3 Expression is Required for the Induction of Osteoblastogenesis of Mesenchymal Stem Cells
Herein researchers show that Smad3, whose expression is stimulated by retinoic acid (RA), relays the effects of RA on differentiation by initiating the displacement of C/EBPß from the Runx2 promoter. [Differentiation]

Maryland Stem Cell Research Commission Funds 36 New Projects in FY 2011
The Maryland Stem Cell Research Commission has completed its review of the 180 applications received in response to its three FY 2011 Requests for Applications. [Maryland Stem Cell Research Fund]

Two Candidates Nominated to Lead California Stem Cell Agency
Southern California investor Jonathan Thomas and cardiologist turned entrepreneur Frank Litvack have been nominated to lead the California Institute of Regenerative Medicine. [ScienceInsider]

Key Patents Granted in United States Strengthen Commercial Rights and Broaden Clinical Indications
Australian regenerative medicine company, Mesoblast Limited, announced that the company’s product development strategy has been significantly strengthened by novel composition of matter claims granted by the United States Patent and Trade Mark Office in two distinct patent families to which Mesoblast has exclusive worldwide commercial rights. [Mesoblast Limited Press Release]

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