De Novo Cardiomyocytes from within the Activated Adult Heart After Injury Investigators demonstrated in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction. [Nature] Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast Scientists described three signaling pathways, involving transforming growth factor-β and canonical and noncanonical Wnt signaling, that collaborate to induce activation of the epithelial-mesenchymal transition program and thereafter function in an autocrine fashion to maintain the resulting mesenchymal state. [Cell] Integrin-Mediated Adhesion and Proliferation of Human MSCs Elicited by a Hydroxyproline-Lacking, Collagen-Like Peptide In this study, researchers evaluated the competence of a rationally designed collagen-like peptide (CLP-Cys) sequence – containing the minimal essential Glycine-Glutamic acid-Arginine triplet but lacking the hydroxyproline residue – for supporting human mesenchymal stem cell (hMSC) adhesion, spreading and proliferation. [Biomaterials] Role of Slug Transcription Factor in Human Mesenchymal Stem Cells Researchers used human mesenchymal stem cells from tibial plateau trabecular bone, iliac crest bone marrow and Wharton’s jelly umbilical cord demonstrating a variability in their mineral matrix deposition, and in the expression levels of transcription factors including Runx2, Sox9, Sox5, Sox6, STAT1 and Slug, all involved in the control of osteochondroprogenitors differentiation program. [J Cell Mol Med] PUMILIO2 is Involved in the Positive Regulation of Cellular Proliferation in Human Adipose-Derived Stem Cells Here researchers show that PUM2 is expressed in a subpopulation of adipose-derived stem cell cultures, with a granular pattern of staining in the cytoplasm. [Stem Cells Dev] Stem Cell Induced Cardiac Regeneration: Fusion/Mitochondrial Exchange and/or Transdifferentiation? In this study researchers demonstrated that cells of fused human adipose tissue derived stem cell-cardiomyocytes display a cardiomyocyte phenotype and spontaneous rhythmic contraction and generate an action potential in vitro. [Cell Cycle] Mesenchymal Stem Cell Seeding Promotes Reendothelialization of the Endovascular Stent This study is designed to make a novel cell seeding stent and to evaluate reendothelialization and anti-restenosis after the stent implantation. [J Biomed Mater Res A] |