An Isoform of Decorin Is a Resistin Receptor on the Surface of Adipose Progenitor Cells By merging phage display technology with fluorescence-activated cell sorting, researchers screened a combinatorial library for peptides that target mouse adipose stromal cells in vivo. [Cell Stem Cell] Engraftment of Human Nasal Olfactory Stem Cells Restores Neuroplasticity in Mice with Hippocampal Lesions Here researchers report that upon transplantation into mice with chemically induced hippocampal lesions, human olfactory ecto–mesenchymal stem cells migrated toward the sites of neural damage, where they differentiated into neurons. [J Clin Invest] PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development To explore the cues that regulate mural cell differentiation and homeostasis, researchers have generated conditional knockin mice with activating mutations at the PDGFRβ locus. [Dev Cell] Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage is Regulated by AMP-Activated Protein Kinase The results provide a potential mechanism involving AMP-activated protein kinase (AMPK) activation in osteogenic differentiation of hAMSC and suggest that commitment of human adipose tissue–derived mesenchymal stem cells to osteogenic or adipogenic lineage is governed by activation or inhibition of AMPK, respectively. [J Cell Physiol] New Simple and Rapid Method for Purification of Mesenchymal Stem Cells from the Human Umbilical Cord Wharton Jelly Researchers have developed a simple and rapid method for isolation of human umbilical cord matrix stem cells. [Tissue Eng Part A] Odd-Skipped Related (Osr) Genes Regulate Differentiation of Embryonic Limb Mesenchyme and Bone Marrow Mesenchymal Stromal Cells Using bone marrow stromal cells (BMSCs) isolated from chicken fetal long bones researchers show that Osr1 and Osr2 have an intrinsic role in BMSC differentiation similar to their role in early embryonic development. [Stem Cells Dev] Adipose Stem Cells Originate from Perivascular Cells Researchers show that adipose stem cells originate from perivascular cells and congregate around blood vessels. [Biol Cell] Induction of Fracture Repair by Mesenchymal Cells Derived from Human Embryonic Stem Cells or Bone Marrow Researchers evaluated the capacity of human embryonic stem cell (hESC)-derived mesenchymal stem/stromal cells to induce healing in a fracture non-union model in rats. [J Orthop Res] Transplantation of Adipose-Derived Stem Cells for Peripheral Nerve Repair Researchers suggest that adipose-derived stem cells (ADSC) can promote the repair of peripheral nerve injury, and the combination of ADSC and acellular nerve allograft transplantation is a new therapeutic method for long distant peripheral nerve defects. [Int J Mol Med] |