Mesenchymal Cell News Volume 3.29 | Jul 26 2011

Mesenchymal Stem Cells Expressing Insulin-Like Growth Factor-I (MSC^IGF) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knock-Out Mice: Analyses of MSC^IGF Autocrine and Paracrine Regenerative Effects
The primary objective of this study is to find a novel mean, by transplanting primary cultures of bone marrow-derived mesenchymal stem cells (MSC) expressing insulin-like growth factor-I (MSC^IGF), to promote these seed-and-soil actions of MSC to fully implement their regenerative abilities in fracture repair and non-unions. [Stem Cells]

A Modular Approach to the Engineering of a Centimeter-Sized Bone Tissue Construct with Human Amniotic Mesenchymal Stem Cell-Laden Microcarriers
In the present study, researchers investigated the feasibility of using microcarriers seeded with adult mesenchymal stem cells (MSCs) to fabricate a large bone tissue. [Biomaterials]

A Comparison between Adipose Tissue and Dental Pulp as Sources of MSCs for Tooth Regeneration
In this study, several in vivo and in vitro comparisons were performed to test the possibility of using adipose-derived stem cells, a more convenient cell source than dental pulp stem cells, in tooth regeneration. [Biomaterials]

The Role of Cell Surface Markers and Enamel Matrix Derivatives on Human Periodontal Ligament Mesenchymal Progenitor Responses In Vitro
In this in vitro study, researchers identify periodontal ligament progenitor cells from multiple individuals and demonstrate that enamel matrix derivative stimulates them. [Biomaterials]

Repair of Critical-Sized Rat Calvarial Defects Using Genetically Engineered BMSCs Overexpressing HIF-1a
In this study, researchers tested the hypothesis that HIF-1a gene therapy could be used to promote the repair of critical-sized bone defects. [Stem Cells]

Pigment Epithelial-Derived Factor and Melanoma Differentiation Associated Gene-7 Cytokine Gene Therapies Delivered by Adipose-Derived Stromal/Mesenchymal Stem Cells are Effective in Reducing Prostate Cancer Cell Growth
The goal was to examine the potential of adipose-derived stromal/mesenchymal stem cells to deliver cytokine gene therapies melanoma differentiation associated gene-7 (MDA-7) or pigment epithelial-derived factor (PEDF) to cancer cells. [Stem Cells Dev]

Mesenchymal Stem Cell Delivery into Rat Infarcted Myocardium Using a Porous Polysaccharide-Based Scaffold: A Quantitative Comparison with Endocardial Injection
This study was designed to quantitatively compare mesenchymal stem cell engraftment rates after delivery using a polysaccharide-based porous scaffold or endocardial injection in a rat myocardial infarction model. [Tissue Eng Part A]

Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells
Researchers investigated the effect of a catabolic environment on chondrogenesis in pellet cultures of human mesenchymal stem cells. [Tissue Eng Part A]

Mesenchymal Stem Cells Promote the Sustained Expression of CD69 on Activated T-Lymphocytes: Roles of Canonical and Non-Canonical NF-κB Signaling
Given its enormous therapeutic potential, researchers explored the molecular mechanisms underlying the induction of regulatory cells by mesenchymal stem cells. [J Cell Mol Med]

Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model
This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells can effectively attenuate acute pulmonary ischemia-reperfusion injury. [J Transl Med]

Cell Cycle Regulators are Critical for Maintaining the Differentiation Potential and Immaturity in Adipogenesis of Adipose-Derived Stem Cells
In this study, researchers analyzed changes in the differentiation potency of adipose tissue-derived stem cells according to the number of spontaneous cell divisions. [Differentiation]

Ottawa Hospital Researchers Awarded $4.8 Million from Ontario Research Fund to Advance Regenerative Medicine and Patient Safety
Two research teams affiliated with the Ottawa Hospital Research Institute, The Ottawa Hospital and the University of Ottawa have been awarded major new grants through the Ontario Research Fund – Research Excellence competition. [Ottawa Hospital Research Institute Press Release]

University of Pittsburgh Receives $67.3 Million to Translate Science into Therapies
A University of Pittsburgh institute aimed at accelerating the pace of translating science into real-life treatments for patients has received $67.3 million from the National Institutes of Health to expand its work over the next five years. [University of Pittsburgh Medical Center Press Release]

Columbia University Medical Center Receives $38.9 Million to Help Translate Science into Treatment
The Irving Institute for Clinical and Translational Research is among 10 institutes nationwide to receive renewed funding, in recognition of their successes during the first five years of the Clinical and Translational Science Awards program. [Columbia University Medical Center Press Release]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

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