Mesenchymal Cell News Volume 3.30 | Aug 2 2011

Human Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells Downregulate NK Cell Cytolytic Machinery
Researchers have generated mesenchymal stem cells (MSC) from human induced pluripotent stem (IPS-MSC) cells that share similar properties with embryonic stem cells (ES-MSC). Herein, researchers compared the immunoregulatory properties of ES/IPS-MSC with those of BM-MSC and showed, for the first time, that IPS-derived MSC display remarkable inhibition of NK cell proliferation and cytolytic function in a similar way to ES-MSC. [Blood]

Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide
Herein, researchers report that the strong noncovalent binding abilities of graphene allow it to act as a preconcentration platform for osteogenic inducers, which accelerate mesenchymal stem cells growing on it toward the osteogenic lineage. [ACS Nano]

The Development of a Novel Cancer Immunotherapeutic Platform Using Tumor-targeting Mesenchymal Stem Cells and a Protein Vaccine
Taking advantage of the tumor-homing property of mesenchymal stem cells (MSCs) and PE(ΔIII)-E7-KDEL3, researchers used E6/E7-immortalized human MSCs as an E7 antigen-delivering vehicle to test if this protein vaccine could effectively eliminate non-E7-expressing tumor cells. [Mol Ther]

The Novel Role of SERPINB9 in Cytotoxic Protection of Human Mesenchymal Stem Cells
Examination of the mechanisms by which allogeneic mesenchymal stem cells (MSCs) evade the host immune response, which is crucial for their therapeutic use, demonstrated that constitutive expression of serine protease inhibitor 9 (PI-9) on human peripheral blood MSCs and bone marrow-derived MSCs is a major defense mechanism against granzyme B-mediated destruction by NK cells. [J Immunol]

Efficient Differentiation of Human Pluripotent Stem Cells into Mesenchymal Stem Cells by Modulating Intracellular Signaling Pathways in a Feeder-/Serum-Free System
Here, an efficient protocol is demonstrated for generating human pluripotent stem cell-derived mesenchymal stem cells under a feeder-free culture system by regulating signaling pathways. [Stem Cells Dev]

Initial Binding and Re-Cellularization of De-Cellularized Mouse Lung Scaffolds with Bone Marrow-Derived Mesenchymal Stromal Cells
To explore the potential utility of stem and progenitor cells in this model, researchers investigated re-cellularization of de-cellularized whole mouse lungs following intratracheal inoculation of bone marrow-derived mesenchymal stromal cells. [Tissue Eng Part A]

MicroRNA-145 Regulates Chondrogenic Differentiation of Mesenchymal Stem Cells by Targeting Sox9
To investigate the mechanisms for miRNA-mediated regulation of chondrogenic differentiation, researchers identified that miR-145 was decreased during transforming growth factor beta 3 (TGF-β3)-induced chondrogenic differentiation of murine mesenchymal stem cells. [PLoS ONE]

The Metabolism of Human Mesenchymal Stem Cells during Proliferation and Differentiation
The present investigation measured the oxygen consumption, glucose consumption and lactate production of mesenchymal stem cells during proliferation and subsequent differentiation towards the osteogenic and chondrogenic lineages. [J Cell Physiol]

Simulated Intervertebral Disc-Like Assembly Using Bone Marrow-Derived Mesenchymal Stem Cell Sheets and Silk Scaffolds for Annulus Fibrosus Regeneration
The objective of this study was to investigate whether the use of bone marrow-derived mesenchymal stem cells to form cell sheets, and incorporating them onto silk scaffolds, has the potential to regenerate the annulus fibrosus. [J Tissue Eng Regen Med]

Fiber Stretch and Reorientation Modulates Mesenchymal Stem Cell Morphology and Fibrous Gene Expression on Oriented Nanofibrous Microenvironments
In this work, macroscopic strain applied to mesenchymal stem cells in an aligned nanofibrous microenvironment elicited cellular and nuclear deformations that varied depending on scaffold orientation. [Ann Biomed Eng]

Launch of Three New Research Projects Offers Hope to MS Patients
Funding for the projects has resulted from a recent collaboration between the UKSCF and the MS Society, which jointly raised a fund of £1 million for translational stem cell MS research projects. [UK Stem Cell Foundation (UKSCF) Press Release]

Osiris Therapeutics Announces Second Quarter 2011 Financial Results Conference Call
Osiris Therapeutics, Inc. announced that it will report its financial results for the second quarter ended June 30, 2011, on Friday, August 5, 2011. [BusinessWire]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

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