Mesenchymal Cell News Volume 3.31 | Aug 9 2011

Gsα Enhances Commitment of Mesenchymal Progenitors to the Osteoblast Lineage but Restrains Osteoblast Differentiation in Mice
In this study, researchers set out to determine the role of Gsα signaling in cells of the early osteoblast lineage in vivo by conditionally deleting Gsα from osterix-expressing cells. [J Clin Invest]

Bone Marrow-Derived Mesenchymal Stem Cells from Early Diffuse Systemic Sclerosis Exhibit a Paracrine Machinery and Stimulate Angiogenesis In Vitro
The objective of this study was to characterise bone marrow-derived mesenchymal stem cells (MSCs) from patients with systemic sclerosis for the expression of factors implicated in MSC recruitment at sites of injury, angiogenesis and fibrosis. [Ann Rheum Dis]

Skeletal Stem Cell Physiology on Functionally Distinct Titania Nanotopographies
Mesenchymal stem cell responses to titanium substrates patterned with nanopillar structures were investigated in this study. [Biomaterials]

Changes of Chondrocyte Expression Profiles in Human MSC Aggregates In the Presence of PEG Microspheres and TGF-β3
To address whether the presence of microparticles could themselves affect differentiation of mesenchymal stem/stromal cells (MSCs), a 3D co-aggregate system was developed containing an equal volume of human primary bone marrow-derived MSCs and non-degradable RGD-conjugated poly(ethylene glycol) microspheres (PEG-μs). [Biomaterials]

Combined Use of Decellularized Allogeneic Artery Conduits with Autologous Transdifferentiated Adipose-Derived Stem Cells for Facial Nerve Regeneration in Rats
The purpose of this study was to investigate the effects of a decellularized allogeneic artery conduit containing autologous transdifferentiated adipose-derived stem cells on an 8-mm facial nerve branch lesion in a rat model. [Biomaterials]

TNF Inhibits Mesenchymal Stem Cell Differentiation into Osteoblasts via the Ubiquitin E3 Ligase Wwp1
To test if TNF inhibits bone formation by affecting the commitment and differentiation of mesenchymal stem cells (MSCs) into osteoblasts, researchers examined the osteogenic potential of MSCs from TNF transgenic mice, a model of chronic inflammatory arthritis. [Stem Cells]

Heterozygous Inactivation of Gnas in Adipose-Derived Mesenchymal Progenitor Cells Enhances Osteoblast Differentiation and Promotes Heterotopic Ossification
The data suggests that Gnas is a key regulator of fate decisions in adipose-derived mesenchymal progenitor cells, specifically those that are involved in bone formation. [J Bone Miner Res]

Nicotinamide Phosphoribosyltransferase (Nampt) Affects the Lineage Fate Determination of Mesenchymal Stem Cells: a Possible Cause for Reduced Osteogenesis and Increased Adipogenesis in Older Individuals
Researchers found that osteoblast differentiation was reduced while adipocyte formation increased in bone marrow stromal cells derived from aged mice compared with young controls. [J Bone Miner Res]

In Vitro Adipogenesis of Adipose-Derived Stem Cells in 3D Fibrin Matrix of Low Component Concentration
This study evaluated the suitability of adipose-derived stem cells combined with fibrin matrix of variable composition for adipose tissue-equivalent formation in vitro. [J Tissue Eng Regen Med]

Effect of Replicated Polymeric Substrate with Lotus Surface Structure on Adipose-Derived Stem Cell Behaviors
Researchers fabricated polystyrene substrates with lotus leaf surface structure and investigated cell behaviors, including attachment, morphology, proliferation, and differentiation of adipose-derived stem cells on them. [Macromol Biosci]

Proliferation and Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells in Porous Hyaluronic Acid Scaffold
Researchers prepared the PEGDG-crosslinked porous three-dimensional hyaluronic acid scaffold and evaluated for its feasibility to induce proliferation and chondrogenic differentiation of the human adipose-derived mesenchymal stem cells. [J Biosci Bioeng]

AlloSource Joins Alliance for Regenerative Medicine, Medical Device Manufacturers Association
AlloSource announced two new key affiliations with the Alliance for Regenerative Medicine and the Medical Device Manufacturers Association. [PR Newswire]

IntelliCell BioSciences, Inc. Announces It Will Open Adipose Tissue Processing Center in Baton RougeIntelliCell BioSciences, Inc. announced it has signed an agreement to open an Adipose Stem Cell Processing Center in Baton Rouge, Louisiana in the next six weeks. [BioPortfolio]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)

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