Erythropoietin Gene-Enhanced Marrow Mesenchymal Stromal Cells Decrease Cisplatin-Induced Kidney Injury and Improve Survival of Allogeneic Mice The study demonstrates that Epo gene-enhanced mesenchymal stromal cells exert significant tissue protective effects in allogeneic mice with acute kidney injury, and supports the potential use of gene-enhanced cells as universal donors in acute injury. [Mol Ther] Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migration In Vitro and In Vivo The aim of this work was to analyze the capacity of human mesenchymal stromal cells to migrate and anchor to hepatocellular carcinoma tumors. [Mol Pharm] 14S,21R-Dihydroxy-Docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury In this report, using a murine model of renal ischemia/reperfusion (I/R) injury, researchers found that treatment with 14S,21R-diHDHA enhanced mesenchymal stem cell amelioration of renal I/R injury. [Stem Cells Dev] Periostin Mediates Human Adipose Tissue-Derived Mesenchymal Stem Cell-Stimulated Tumor Growth in a Xenograft Lung Adenocarcinoma Model In the present study, researchers demonstrate that conditioned medium from A549 human lung adenocarcinoma cells induces expression of periostin, an extracellular matrix protein, in human adipose tissue-derived mesenchymal stem cells. [Biochim Biophys Acta] Degenerate Wave and Capacitive Coupling Increase Human MSC Invasion and Proliferation While Reducing Cytotoxicity in an In Vitro Wound Healing Model Researchers compared the effects of direct current, capacitive coupling, pulsed electromagnetic field and degenerate wave on cellular activities including cytotoxicity, proliferation, cell-kinetics and apoptosis by stimulating human-bone marrow mesenchymal stem cells 3 hours a day, up to 5 days. [PLoS ONE] Optimized Conditions for Mesenchymal Stem Cells to Differentiate Into Osteoblasts on a Collagen/Hydroxyapatite Matrix The study confirmed that a higher collagen content increased scaffold stiffness but that a greater stiffness was not sufficient for bone tissue formation, a complex process evidently also dependent on scaffold porosity. [J Biomed Mater Res A] Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Cells in Collagen Scaffolds Researchers compared the potential of bone marrow-derived mesenchymal stem cells and P19 embryonic carcinoma cells, a pluripotent derivative of embryonic stem cells, for cartilage histogenesis in porous collagen scaffolds in vitro. [J Biomed Mater Res A] Induction of Autologous Mesenchymal Stem Cells in the Bone Marrow by Low-Level Laser Therapy has Profound Beneficial Effects on the Infarcted Rat Heart In this study, researchers investigated the hypothesis that photobiostimulation of autologous bone-marrow-derived mesenchymal stem cells by low-level laser therapy applied to the bone marrow, may migrate to the infarcted area and thus attenuate the scarring processes following myocardial infarction. [Lasers Surg Med] Effects of Mesenchymal Stem Cells on Matrix Metalloproteinase Synthesis in Cardiac Fibroblasts This study investigated the effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts through paracrine actions. [Exp Biol Med] GATA-4 Promotes Myocardial Transdifferentiation of Mesenchymal Stromal Cells via Up-Regulating IGFBP-4 Researchers investigated whether overexpression of GATA-4 increases adult mesenchymal stromal cell transdifferentiation into a cardiac phenotype in vitro. [Cytotherapy] |