Mesenchymal Cell News Volume 3.37 | Sep 20 2011

USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma
Researchers show that the deubiquitinating enzyme USP1 promotes ID protein stability and stem cell-like characteristics in osteosarcoma. [Cell] Abstract

The Effect of Micro and Nanotopography on Endocytosis in Drug and Gene Delivery Systems
The results showed increased internalization of fluorescently labeled dextran by human mesenchymal stem cells and monkey kidney fibroblasts (COS7) when they were cultured on micro- and nanopillars. [Biomaterials] Abstract

Gadd45a Plays an Essential Role in Active DNA Demethylation during Terminal Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells
Researchers provide evidence that active DNA demethylation does occur during terminal specification of stem cells in an adipose-derived mesenchymal stem cell-derived osteogenic differentiation model. [J Biol Chem] Abstract

Mesenchymal Stem Cell-Secreted Soluble Signaling Molecules Potentiate Tumor Growth
In the present study, researchers investigate whether the physical presence or the continuous presence of mesenchymal stem cells (MSCs) is required for enhanced tumor growth, and they found that pretreatment of tumor cells SGC-7901 with a single dose of hMSC-conditioned medium in vitro is sufficient to potentiate tumor growth comparable to the effect of MSC co-injection in vivo in mouse xenograft models. [Cell Cycle] Abstract

The Influence of Construct Scale on the Composition and Functional Properties of Cartilaginous Tissues Engineered Using Bone-Marrow Derived Mesenchymal Stem Cells
The objective of this study was to determine how the composition and mechanical properties of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells depend on the scale of the construct. [Tissue Eng Part A] Abstract

Treatment Outcomes of Alginate-Embedded Allogenic Mesenchymal Stem Cells Versus Autologous Chondrocytes for the Repair of Focal Articular Cartilage Defects in a Rabbit Model
Treatment with allogenic undifferentiated mesenchymal stem cells has similar effectiveness as autologous chondrocyte treatment for repair of focal cartilage defects. Both treatments resulted in superior tissue regeneration compared with untreated defects. [Am J Sports Med] Abstract

MicroRNA-34a Modulates Genes Involved in Cellular Motility and Oxidative Phosphorylation in Neural Precursors Derived from Human Umbilical Cord Mesenchymal Stem Cells
The data suggest a critical role of miRNAs in mesenchymal stem cell neuronal differentiation, and miR-34a contributes in neuronal precursor motility, which may be crucial for stem cells to home to the target sites they should be. [BMC Med Genomics] Abstract

Mesenchymal Stem Cell-Conditioned Medium Facilitates Angiogenesis and Fracture Healing in Diabetic Rats
Researchers demonstrate in this report that mesenchymal stem cells-derived conditioned medium delivered in gelatin sponges stimulates angiogenesis and promotes fracture healing in a diabetic rat model. [J Tissue Eng Regen Med] Abstract

Human Peripheral Blood Derived Mesenchymal Stem Cells Demonstrate Similar Characteristics and Chondrogenic Differentiation Potential to Bone Marrow Derived Mesenchymal Stem Cells
The objectives of this study are to isolate and characterize mesenchymal stem cells (MSCs) derived from peripheral blood and, compare their chondrogenic potential to MSC derived from bone marrow. [J Orthop Res] Abstract

Isolation and Basic Characterization of Human Term Amnion and Chorion Mesenchymal Stromal Cells
The results indicate that mesenchymal stromal cells (MSC) can be easily isolated from the human term placenta. The human amniotic and chorion MSC maintained a marker profile similar to the mesenchymal progenitors and could be used for studies as an alternative source of MSC for further application in cellular therapy. [Cytotherapy] Abstract

Modification of the Alkaline Comet Assay with Human Mesenchymal Stem Cells
For monitoring of in vitro senescence of mesenchymal stem cells (MSCs) researchers assessed the integrity of DNA by means of the alkaline comet assay. [Cell Biol Int] Abstract

Bioheart Announces US FDA Clinical Program Using Adipose Cells
Bioheart, Inc. announced that they will begin a US clinical program called the ANGEL trial utilizing adipose derived cells or LipiCell for congestive heart failure patients. [MarketWatch] Press Release

Genetics Policy Institute Announces 2011 “Stem Cell Action” Award Winners and Honorees
The Genetics Policy Institute will honor individuals and organizations that have positively impacted the advancement of stem cell research at the 7th Annual Stem Cell Action Awards Dinner on October 4, 2011. [Genetic Engineering & Biotechnology News] Press Release

University of Pittsburgh Receives $3.54 Million Grant
The Swanson School of Engineering at the University of Pittsburgh has received a $3.54 million grant from the Wallace H. Coulter Foundation. [University of Pittsburgh] Press Release

Aastrom Announces Positive 12-Month Safety and Efficacy Data From IMPACT-DCM Phase 2 Clinical Trial for Ixmyelocel-T in Treatment of Dilated Cardiomyopathy
Aastrom Biosciences, Inc. announced that 12-month follow up data from the IMPACT-DCM clinical trial for ixmyelocel-T showed that treatment was well-tolerated and that efficacy observations were consistent with improved function of impaired myocardium in patients with dilated cardiomyopathy including ischemic cardiomyopathy and idiopathic dilated cardiomyopathy. [Aastrom Biosciences, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)

NEW VI Brazilian Congress on Stem Cells and Cell Therapy
September 28-October 1, 2011
Salvador, Brazil

Visit our events page to see a complete list of events in the mesenchymal cell community.

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

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