Mesenchymal Cell News Volume 3.40 | Oct 11 2011

Artificial Niche Microarrays for Probing Single Stem Cell Fate in High Throughput
Researchers report a microengineered platform comprised of soft hydrogel microwell arrays with modular stiffness (shear moduli of 1–50 kPa) in which individual microwells can be functionalized with combinations of proteins spotted by robotic technology. To validate the platform, researchers tested the effect of cell-cell interactions on adipogenic differentiation of adherent human mesenchymal stem cells (MSCs) and the effect of substrate stiffness on osteogenic MSC differentiation. [Nat Methods] Abstract

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
Here, researchers report that primary human mesenchymal stem cells undergoing differentiation into adipocytes display an early increase in mitochondrial metabolism, biogenesis, and reactive oxygen species (ROS) generation. [Cell Metab] Abstract

Human Gingiva-Derived Mesenchymal Stromal Cells Attenuate Contact Hypersensitivity via Prostaglandin E2-Dependent Mechanisms
Here, researchers report a new immunological approach using human gingiva-derived mesenchymal stromal cells to desensitize and suppress contact hypersensitivity and the underlying mechanisms. [Stem Cells] Abstract

Modulation of Osteogenic Differentiation in hMSCs Cells by Submicron Topographically-Patterned Ridges and Grooves
Researchers used topographically-patterned substrates containing anisotropically ordered ridges and grooves to investigate the effects of topographic cues on mesenchymal stem cell (MSC) morphology, proliferation, and osteogenic differentiation. [Biomaterials] Abstract

High-Resolution Imaging and Antitumor Effects of GFP+ Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors
Researchers have established a mouse model for imaging bone marrow-derived cells from whole tumor to single-cell resolution, whereby the bone marrow of lethally irradiated host animals is reconstituted with EGFP-expressing bone marrow cells from matched TgActb(EGFP) donors. [Am J Pathol] Abstract | Press Release

Developmental Regulation of TAC1 in Peptidergic-Induced Human Mesenchymal Stem Cells: Implication for Spinal Cord Injury in Zebrafish
This study investigated the molecular pathway in TAC1 induction as mesenchymal stem cells differentiated into neurons and then applied the findings in a model of spinal cord injury in zebrafish. [Stem Cells Dev] Abstract | Press Release

miR-486-5p Induces Replicative Senescence of Human Adipose Tissue-Derived Mesenchymal Stem Cells and its expression is controlled by high glucose
Through a microarray approach, researchers have identified miR-486-5p, of which expression is progressively expressed in human adipose tissue-derived mesenchymal stem cells with aging. [Stem Cells Dev] Abstract

Molecular Analysis of the Differentiation Potential of Murine Mesenchymal Stem Cells from Tissues of Endodermal or Mesodermal Origin
To better understand the relationship between mesenchymal stem cells resident in different tissues, researchers analyzed the expression of genes related to pluripotency (SOX2 and OCT-4) and to adipogenic (C/EBP and ADIPOR1), osteogenic (OMD and ALP) and chondrogenic (COL10A1 and TRPV4) differentiation in cultures derived from murine endodermal (lung) and mesodermal (adipose) tissue maintained in different conditions. [Stem Cells Dev] Abstract

Mesenchymal Stem Cell Transplantation for the Infarcted Heart: A Role in Minimizing Abnormalities in Cardiac-Specific Energy Metabolism
This study examines the ability of mesenchymal stem cells to rescue the infarcted heart from perturbed substrate uptake in vivo. [Am J Physiol Endocrinol Metab] Abstract

Mesenchymal Stem Cells Exhibit Firm Adhesion, Crawling, Spreading and Transmigration across Aortic Endothelial Cells: Effects of Chemokines and Shear
This study examines the interaction of murine mesenchymal stem cells with, and their migration across, murine aortic endothelial cells, and the effects of chemokines and shear stress. [PLoS ONE] Abstract

Bone Marrow Derived Mesenchymal Stem Cells Inhibit Inflammation and Preserve Vascular Endothelial Integrity in the Lungs after Hemorrhagic Shock
The data suggests that mesenchymal stem cells, acting directly and through soluble factors, are potent stabilizers of the vascular endothelium and inflammation. [PLoS ONE] Abstract

Cellerix Secures €4.95 Million for Phase III Study of Allogeneic Adult Stem Cell Therapy
Cellerix has secured a €4.95 million soft loan from the nonprofit Madrid Network, to support Phase III development of lead expanded allogeneic adult stem cell product. [Genetic Engineering & Biotechnology News] Press Release

Scientific Luminary Dr. Robert Langer Joins ACT’s Board of Directors
Advanced Cell Technology, Inc. (ACT) announced that Robert S. Langer, David H. Koch Institute Professor at the Massachusetts Institute of Technology, has been appointed to the company’s Board of Directors, and will also serve as the Chair of the Board’s Science Advisory Committee. [Advanced Cell Technology, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

Postdoctoral Research Assistant Grade 7 (University of Oxford)

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