Differential Effects of Dexamethasone on the Chondrogenesis of Mesenchymal Stromal Cells: Influence of Microenvironment, Tissue Origin and Growth Factor Researchers hypothesize that the influence of dexamethasone on the chondrogenesis of mesenchymal stromal cells depends upon their tissue origin and microenvironment (absence or presence of an extracellular matrix), as well as upon the nature of transforming-growth-factor-β. [Eur Cell Mater] Abstract Preconditioning by Phosphodiesterase-5 Inhibition Improves Therapeutic Efficacy of Adipose Derived Stem Cells following Myocardial Infarction in Mice Researchers tested the hypothesis that inhibition of phosphodiesterase-5 with sildenafil or knockdown with a silencing vector in adipose derived stem cells would improve their survival and enhance cardiac function following myocardial implantation in vivo. [Stem Cells] Abstract Bone Marrow Derived Mesenchymal Stromal Cells Are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo In this study, in vitro and in vivo migration assays revealed that mesenchymal stromal cells (MSCs) have tropism towards multiple myeloma (MM) cells and CCL25 was identified as a major MM cell-produced chemoattractant for MSCs. [Stem Cells] Abstract Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential Here researchers show that, after in vitro induction of neuronal differentiation and dedifferentiation, on withdrawal of extrinsic factors, mesenchymal stem cells derived from bone marrow, which have already committed to neuronal lineage, revert to a primitive cell population retaining stem cell characteristics but exhibiting a reprogrammed phenotype distinct from their original counterparts. [Stem Cells] Abstract Mesenchymal Stem Cells Enhance Recovery and Repair following Ventilator-Induced Lung Injury in the Rat This study was undertaken to determine the potential for mesenchymal stem cells to enhance repair after ventilator-induced lung injury and elucidate the mechanisms underlying these effects. [Thorax] Abstract PPARγ Suppression Inhibits Adipogenesis but Does Not Promote Osteogenesis of Human Mesenchymal Stem Cells In this study, using human mesenchymal stem cells (hMSCs) as an in vitro model, researchers showed that the two isoforms of proliferator-activated receptor γ (PPARγ), PPARγ1 and PPARγ2, were differentially induced during hMSC adipogenesis, whereas only PPARγ1 was detected during osteogenesis. [Int J Biochem Cell Biol] Abstract Differential Mesengenic Potential and Expression of Stem Cell Fate Modulators in Mesenchymal Stromal Cells from Human Term Placenta and Bone Marrow In this study, scientists characterized ex vivo expanded mesenchymal stromal cells (MSCs) from the human amniotic and chorionic membranes of human full term placentas and adult bone marrow. [J Cell Physiol] Abstract Suppression of Allergic Airway Inflammation in a Mouse Model of Asthma by Exogenous Mesenchymal Stem Cells Researchers investigated whether exogenous mesenchymal stem cells (MSCs) can relocate to lung tissues in asthmatic mice, analyzed this chemotactic mechanism and evaluated the in vivo immunomodulatory effect of exogenous MSCs in asthma. [Exp Biol Med] Abstract |