Pharmacological Modulation of Human Mesenchymal Stem Cell Chondrogenesis by a Chemically Over-Sulphated Polysaccharide of Marine Origin: Potential Application to Cartilage Regenerative Medicine Here, researchers hypothesize that growth factor-induced differentiation of mesenchymal stem cells can be increased by chemically over-sulphated marine polysaccharides. [Stem Cells] Abstract Changes in Expression of the Antioxidant Enzyme SOD3 Occur upon Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells In Vitro The aim of this study was to investigate in vitro if mesenchymal stem cell differentiation down the adipogenic, chondrogenic and osteogenic lineages influences the expression of the antioxidant molecule SOD3. [Stem Cells Dev] Abstract Temporal Activation of ß-Catenin Signaling in the Chondrogenic Process of Mesenchymal Stem Cells Affects the Phenotype of the Cartilage Generated This study investigated the temporal effect of transforming growth factor-ß and ß-catenin signaling co-activation during mesenchymal stem cell chondrogenic differentiation and evaluated the influence of these pre-differentiation conditions to subsequent phenotypic development of the cartilage. [Stem Cells Dev] Abstract Molecular Imaging of Mesenchymal Stem Cell: Mechanistic Insight into Cardiac Repair following Experimental Myocardial Infarction In this study, researchers found increased angiogenesis and decreased fibrosis were associated with cardiac functional improvement following human mesenchymal stem cell transplantation. [Circ Cardiovasc Imaging] Abstract Hypoxia Inhibits the Spontaneous Calcification of Bone Marrow-Derived Mesenchymal Stem Cells In this study, spontaneous calcification of bone marrow-derived mesenchymal stem cells from rats was evaluated in normoxia without osteogenic medium after continuous culture for 21 days. [J Cell Biochem] Abstract TSH-Induced Gene Expression Involves Regulation of Self-Renewal and Differentiation-Related Genes in Human Bone Marrow-Derived Mesenchymal Stem Cells In this study, researchers investigated expression and biological consequence of thyroid-stimulating hormone (TSH) receptor interactions in mesenchymal stem cells of cultured human bone marrow. [J Endocrinol] Abstract Adipose-Derived Stem Cells Promote Lymphangiogenesis in Response to VEGF-C Stimulation or TGF-ß1 Inhibition The purpose of this study was to determine whether adipose-derived stem cells can be used in lymphatic tissue-engineering by altering the balance between pro- and anti-lymphangiogenic cytokines. [Future Oncol] Abstract Simvastatin Inhibits Sphingosylphosphorylcholine-Induced Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle Cells In the present study, researchers examined the effects of simvastatin on the sphingosylphosphorylcholine-induced α-smooth muscle actin expression and Smad2 phosphorylation in human adipose tissue-derived mesenchymal stem cells. [Exp Mol Med] Abstract |