Direct and Efficient Cellular Transformation of Primary Rat Mesenchymal Precursor Cells by KSHV Here, researchers report efficient infection and cellular transformation of primary rat embryonic metanephric mesenchymal precursor cells by kaposi’s sarcoma-associated herpesvirus (KSHV). [J Clin Invest] Abstract | Press Release Mesenchymal Stromal Cells Orchestrate Follicular Lymphoma Cell Niche through the CCL2-Dependent Recruitment and Polarization of Monocytes Researchers show here that bone marrow-mesenchymal stromal cells (MSC) obtained from follicular lymphoma patients display a specific gene expression profile compared to MSC obtained from healthy age-matched donors. [Blood] Abstract Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stem cells occurs widely in patients with multiple myeloma (MM), but the pathophysiological effects of GDF15 in this setting remain undefined. In this study, researchers report that GDF15 significantly increases survival of stroma-dependent MM cells including primary MM cells. [Cancer Res] Abstract A Calcium-Induced Signaling Cascade Leading to Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells Here, researchers have created an in vitro environment with high extracellular calcium concentration and investigated the response of human bone marrow-derived mesenchymal stromal cells to it. [Biomaterials] Abstract Adipose Tissue-Derived Mesenchymal Stem Cells Improve Revascularization Outcomes to Restore Renal Function in Swine Atherosclerotic Renal Artery Stenosis Researchers hypothesized that replenishment of mesenchymal stem cells as an adjunct to percutaneous transluminal renal angioplasty would restore renal cellular integrity and improve renal function in atherosclerotic renal artery stenosis pigs. [Stem Cells] Abstract Potently Immunosuppressive 5-Fluorouracil-Resistant Mesenchymal Stromal Cells Completely Remit an Experimental Autoimmune Disease Researchers treated mice with 5-fluorouracil (5-FU) to isolate a quiescent and undifferentiated mesenchymal stromal cell (MSC) population from the bone marrow. These 5-FU-resistant MSCs free from hematopoietic components were examined for CFU fibroblasts and their immunosuppressive potential in vitro and in vivo was assessed. [J Immunol] Abstract Short-Term Exposure to Tumor Necrosis Factor-α Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation Researchers demonstrate that the p38 mitogen-activated protein kinase signaling pathway regulates the expression of bone morphogenetic protein-2 in osteoblasts, which then acts through a paracrine loop, to direct the osteoblast lineage commitment of mesenchymal stem cells. [Stem Cells Dev] Abstract Hypoxic Preconditioning Enhances Survival of Human Adipose-Derived Stem Cells and Conditions Endothelial Cells In Vitro Here researchers report the protective effects of hypoxic preconditioning and identify mechanisms for improving survival of adipose-derived stem cells in vitro. [Stem Cells Dev] Abstract |