Mesenchymal Cell News Volume 4.08 | Feb 28 2012

Noggin Is a Novel Inducer of Mesenchymal Stem Cell Adipogenesis: Implications for Bone Health and Obesity
Scientists report here for the first time a novel mechanism by which noggin directly induces adipogenesis of mesenchymal stem cells, independently of major human adipogenic signals through C/EBPδ, C/EBPα and PPAR-γ. [PLoS One] Abstract

Autophagy Activation: A Novel Mechanism of Atorvastatin to Protect Mesenchymal Stem Cells from Hypoxia and Serum Deprivation via AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway
Here researchers demonstrated that hypoxia/serum deprivation induced autophagy in mesenchymal stem cells significantly as identified by increasing acidic vesicular organelles-positive cells, type II of light chain 3 expression and autophagosomes formation. [Stem Cells Dev] Abstract

Mesenchymal Stem Cells Lack Efficacy in the Treatment of Experimental Autoimmune Neuritis Despite In Vitro Inhibition of T-Cell Proliferation
Researchers performed two trials of efficacy of mesenchymal stem cells in experimental autoimmune neuritis in Lewis rats. [PLoS One] Abstract

Dopamine Regulates Mobilization of Mesenchymal Stem Cells during Wound Angiogenesis
As recent reports indicate that mesenchymal stem cells (MSCs) by mobilizing into wound bed play an important role in promoting wound angiogenesis, researchers therefore investigated the effect of dopamine on the migration of MSCs in wound tissues. [PLoS One] Abstract

Paracrine Interactions between Mesenchymal Stem Cells Affect Substrate Driven Differentiation toward Tendon and Bone Phenotypes
Researchers investigated substrate dependent paracrine signaling between subpopulations of bone marrow stromal cells that may affect the formation, or perhaps malformation, of the regenerating tendon to bone enthesis. [PLoS One] Abstract

Regulation of Cell Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel
Researchers’ findings demonstrate that the hEAG1 channel plays a crucial role in controlling the proliferation rate of human induced pluripotent stem cell-mesenchymal stem cells (MSCs) and to a lesser extent in bone marrow-MSCs. [Am J Physiol Cell Physiol] Abstract

Melphalan Exposure Induces an Interleukin-6 Deficit in Bone Marrow Stromal Cells and Osteoblasts
In this current study, researchers investigated the effects of chemotherapy treatment on bone marrow stromal cells and human osteoblast expression of interleukin-6 as one regulatory factor. [Cytokine] Abstract

Mesenchymal Stem Cells with rhBMP-2 Inhibits the Growth of Canine Osteosarcoma Cells
The aim of this study was to analyze the effects of treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2) on the proliferation of canine mesenchymal stem cells and the tumor suppression properties of rhBMP-2 in canine osteocarcoma cells. [BMC Vet Res] Abstract

Four Prestigious Awards to Support Innovative Biomedical Research
Sanofi and the Institut Pasteur announced the creation of the Sanofi-Institut Pasteur Awards to encourage scientific excellence in the service of health. [Sanofi-Institut Pasteur] Press Release

Vomaris Innovations, Inc. Names New CEO
Vomaris Innovations, Inc., a leading regenerative medicine company focusing on wound care with bioelectric technology, has named Michael P. Nagel as its new President and Chief Executive Officer. [PR Newswire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Keystone Symposia on Molecular and Cellular Biology: Regenerative Tissue Engineering and Transplantation
April 1-6, 2012
Breckenridge, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Research Associates/Scientist/Senior Scientist – Stem Cell Research (Advanced Cell Technology) 

PhD Student – Immunotherapy Using Mesenchymal Stem Cells (Charles University)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellow (University of Rochester Medical Center)

Postdoctoral Fellow (Erasmus MC)

PhD Student – Polymer Technology (KTH Royal Institute of Technology)

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