Mesenchymal Cell News Volume 4.15 | Apr 17 2012

Xenotransplanted Embryonic Kidney Provides a Niche for Endogenous Mesenchymal Stem Cell Differentiation into Erythropoietin-Producing Tissue
Researchers established xenotransplantation models that control endogenous mesenchymal stem cell differentiation into mature erythropoietin-producing tissue in a niche provided by a developing xenometanephros. [Stem Cells] Abstract

FGF-2 Maintains a Niche-Dependent Population of Self-Renewing Highly Potent Non-Adherent Mesenchymal Progenitors through FGFR2c
Scientists showed that primary human bone marrow cultures contain a population of intrinsically non-adherent mesenchymal progenitors with features of more primitive progenitors than the initially adhering Colony Forming Units-fibroblast (CFU-f). [Stem Cells] Abstract

In Vivo Tracking of Mesechymal Stem Cells Using Fluorescent Nanoparticles in an Osteochondral Repair Model
Investigators devised and tested an in vivo system to monitor the migration of mesenchymal stem cells within the marrow cavity. [Mol Ther] Abstract

Effects of Multiple Agents on Epithelial Differentiation of Rabbit Adipose-Derived Stem Cells in Three-Dimensional Culture
Scientists investigated the possibility of epithelial differentiation of rabbit adipose-derived stem cells in an in vitro three-dimensional culture system. [Tissue Eng Part A] Abstract

Myocyte-Depleted Engineered Cardiac Tissues Support Therapeutic Potential of Mesenchymal Stem Cells
Investigators found that supplementing myocyte-depleted engineered cardiac tissues with mesenchymal stem cells (MSC) transiently improved contractile function and compensated for a 50% loss of cardiomyocytes, mimicking recent animal studies and clinical trials, thus supporting the potential of MSC for myocardial therapy. [Tissue Eng Part A] Abstract

Acellular Bone Colonization and Aggregate Culture Conditions Diversely Influence Murine Periosteum Mesenchymal Stem Cells Differentiation Potential in Long-Term In Vitro Osteo-Inductive Conditions
Data showed that periosteum-mesechymal stem cells cultured onto acellular bone scaffold develop a complex three-dimensional matrix and an osteoblastic phenotype but do not produce hydroxyapatite; moreover they seem able to reabsorb the colonized bone scaffold. [Tissue Eng Part A] Abstract

Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased Interleukin-6 and Interferon Gamma-Induced Protein-10 Secretion
This work begins to identify the influence of macrophages on mesenchymal stem cell biology. [PLoS One] Abstract

Effect of Cyclic Strain on Cardiomyogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells
Researchers investigated whether a cyclic strain could regulate rat bone marrow derived mesenchymal stem cell differentiation into cardiomyocyte-like lineage. [PLoS One] Abstract

Induction of Superficial Zone Protein (SZP)/Lubricin/PRG 4 in Muscle-Derived Mesenchymal Stem/Progenitor Cells by Transforming Growth Factor-Beta1 and Bone Morphogenetic Protein-7
This investigation demonstrated the efficient and reproducible induction of SZP accumulation by transforming growth factor-beta1 and bone morphogenetic protein-7 in skeletal muscle-derived mesenchymal stem/progenitor cells. [Arthritis Res Ther] Abstract

Intervertebral Disc Repair Phase II Trial Update
Mesoblast Limited announced that its Phase II clinical trial investigating the use of allogeneic mesenchymal precursor cells for non-surgical restoration of degenerated intervertebral discs and treatment of low back pain has enrolled 50% of the total study patients. [Mesoblast Limited] Press Release

TiGenix Rheumatoid Arthritis Phase IIa Study Successfully Passes Last Safety Hurdle
TiGenix announced that, upon review of the safety data of the first three patients of the third cohort of the company’s Phase IIa clinical trial in rheumatoid arthritis, it has received the go-ahead from the independent Safety Monitoring Board to recruit and dose the remaining patients of this cohort. [TiGenix] Press Release

NeoStem Announces the Addition of Jonathan Sackner-Bernstein, MD, as Vice President, Clinical Development and Regulatory Affairs
NeoStem, Inc. announced that Jonathan Sackner-Bernstein, MD, FACC joined the firm as Vice President of Clinical Development and Regulatory Affairs. [NeoStem, Inc.] Press Release

Minneapolis Heart Institute Again Selected to Participate in Cardiovascular Cell Therapy Research Network (CCTRN)
The CCTRN has selected the Minneapolis Heart Institute® as one of its seven U.S. centers of excellence. The network will receive $63 million from the National Institutes of Health and National Heart, Lung and Blood Institute over the next seven years to help achieve its mission of driving public health advances in cardiovascular cell therapy for the treatment of cardiovascular diseases. [BusinessWire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

PhD Student (University of Liège) 

Postdoctoral Position (GENyO)

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