The Use of Autologous Enriched Bone Marrow MSCs to Enhance Osteoporotic Bone Defect Repair in Long-Term Estrogen Deficient Goats Investigators demonstrated that bone marrow mesenchymal stem cells (MSCs) harvested from goats with long-term estrogen deficiencies exhibited a lower proliferation rate and decreased osteogenic capacity. [Biomaterials] Abstract Nanotopography as Modulator of Human Mesenchymal Stem Cell Function Scientists studied a culture of human mesenchymal stem cells on polydimethylsiloxane substrates with 350 nm grating topography and investigated the focal adhesion composition and dynamics using biochemical and imaging techniques. [Biomaterials] Abstract Regulation of the Fate of Human Mesenchymal Stem Cells by Mechanical and Stereo-Topographical Cues Provided by Silicon Nanowires Researchers aimed to delineate the effects of stereotopography and its various relevant physical properties on the fate regulation of human mesenchymal stem cells. [Biomaterials] Abstract Basal Autophagy Decreased during the Differentiation of Human Adult Mesenchymal Stem Cells This study expands the knowledge on the control exerted by Bcl-xL on autophagy and illustrates the important role of autophagy in the maintenance and differentiation of adult human mesenchymal stem cells. [Stem Cells Dev] Abstract The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells Researchers isolated, purified and characterized a previously unrecognized progenitor population from two different regions in the adult human brain. They showed that these cells co-express markers for mesenchymal stem cells and pericytes in vivo and in vitro. [PLoS One] Abstract | Press Release The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury Investigators evaluated the role of the stromal-derived factor-1 (SDF-1)-CXCR4/CXCR7 pathway in regulating chemotaxis, viability and paracrine actions of hypoxic preconditioned-mesenchymal stem cells in vitro and in vivo. [PLoS One] Abstract Effects of Endothelial Cells on Proliferation and Survival of Human Mesenchymal Stem Cells and Primary Osteoblasts Researchers investigated the effect of endothelial cells on proliferation and cell survival of human primary osteoblasts and human mesenchymal stem cells. [J Orthop Res] Abstract Pre-Culturing Human Adipose Tissue Mesenchymal Stem Cells Under Hypoxia Increases Their Adipogenic and Osteogenic Differentiation Potentials Human adipose tissue mesenchymal stem-cells from four human donors were cultured in growth medium under either normoxic or hypoxic conditions for seven days and were then transferred to normoxic conditions to study their differentiation potential. [Cell Prolif] Abstract |