Mesenchymal Cell News Volume 4.17 | May 1 2012

Bone Marrow-Derived Mesenchymal Stem Cells Promote Colorectal Cancer Progression through Paracrine Neuregulin 1/Human Epidermal Growth Factor Receptor 3 Signaling
Bone marrow-derived mesenchymal stem cells migrate to primary tumors and drive tumor progression. Researchers aimed to identify the molecular mechanisms associated with these heterotypic cellular interactions and analyze their relevance in colorectal cancer. [Gut] Abstract

Adult and Umbilical Cord Blood-Derived Platelet-Rich Plasma for Mesenchymal Stem Cell Proliferation, Chemotaxis, and Cryo-Preservation
To compare the ability of various platelet-rich plasma (PRP) products to stimulate proliferation of human bone marrow (BM), rat BM and compact bone-derived mesenchymal stem cells, cells were cultured in serum-free media for four and seven days with varying concentrations of PRP, platelet-poor plasma, or combinations of recombinant mitogens. [Biomaterials] Abstract

Equal Modulation of Endothelial Cell Function by Four Distinct Tissue-Specific Mesenchymal Stem Cells
Scientists demonstrated that tissue-resident mesenchymal stem cells isolated from four distinct tissues have equal capacity to modulate endothelial cell function, including formation of vascular networks in vivo. [Angiogenesis] Abstract

Control of Mesenchymal Lineage Progression by MicroRNAs Targeting the Skeletal Gene Regulators Tricho-Rhino-Phalangeal Syndrome 1 and Runt-Related Transcription Factor 2
Investigators suggested a program of multiple microRNAs controls mesenchymal lineage progression by selectively blocking differentiation of osteoblasts and chondrocytes to control skeletal development. [J Biol Chem] Abstract

Human Amniotic Mesenchymal Stem Cell-Derived Induced Pluripotent Stem Cells May Generate a Universal Source of Cardiac Cells
Researchers investigated the reprogramming efficiency of partially pluripotent human amniotic mesenchymal stem cells (hAMSCs) to generate hAMSC-derived induced pluripotent stem cells (MiPSCs), immunomodulatory properties of the hAMSCs and MiPSCs, and cardiac differentiation potential of the MiPSCs. [Stem Cells Dev] Abstract

Differentiation-Dependent Secretion of Proangiogenic Factors by Mesenchymal Stem Cells
Researchers hypothesized that the proangiogenic potential of mesenchymal stem cells was dependent upon their stage of osteogenic differentiation. [PLoS One] Abstract

Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation
This study determined whether activation of Sirt-1 by the phytoestrogen resveratrol affects osteogenic differentiation. [PLoS One] Abstract

Tubular Perfusion System Culture of Human Mesenchymal Stem Cells on Poly-L-Lactic Acid Scaffolds Produced Using a Supercritical Carbon Dioxide-Assisted Process
Scientists investigated how scaffold microstructure influences human mesenchymal stem cell behavior in a perfusion bioreactor system. [J Biomed Mater Res A] Abstract

Functional Interaction between Mesenchymal Stem Cells and Spiral Ligament Fibrocytes
To elucidate the mechanism of spiral ligament fibrocyte (SLF) repair and to determine the contribution of transplanted mesenchymal stem cells (MSCs) in this model, researchers investigated the mutual effects on differentiation and proliferation between MSCs and SLFs in a coculture system. [J Neurosci Res] Abstract

FDA Approves Votrient® for Treatment of Patients with Certain Types of Advanced Soft Tissue Sarcoma
GlaxoSmithKline plc announced that the U.S. Food and Drug Administration (FDA) has approved Votrient^® for the treatment of patients with advanced soft tissue sarcoma who have received prior chemotherapy. Soft tissue sarcomas constitute a group of rare cancers arising from mesenchymal cells. [PR Newswire]
Press Release

WPI Team Scales-Up Production of Biopolymer Microthreads
Development of new therapies for a range of medical conditions will be supported by a new production-scale microthread extruder designed and built by a team of graduate students and biomedical engineering faculty at Worcester Polytechnic Institute (WPI). [Worcester Polytechnic Institute] Press Release

New Director, Associate Director at McGowan Institute for Regenerative Medicine
William R. Wagner, Ph.D. has been named director of the McGowan Institute for Regenerative Medicine, effective immediately. Rocky S. Tuan, Ph.D. has been named associate director. [University of Pittsburgh Schools of the Health Sciences] Press Release

Chinese Publishers Vow to Cleanse Journals
The China Association for Science and Technology in Beijing has taken the lead among the country’s publishers in trying to clamp down on academic misconduct. [The China Association for Science and Technology, China] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Centre for Regenerative Medicine: Driving Stem Cell Research Towards Therapy
May 21-22, 2012
Edinburgh, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

PhD Student (University of Liège) 

Postdoctoral Position (GENyO)


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