Role of Subnano-, Nano- and Submicron-Surface Features on Osteoblast Differentiation of Bone Marrow Mesenchymal Stem Cells This study systematically controlled titanium surface features from the sub-nano to sub-micron scales and investigated the corresponding effects on stem cell responses, such as integrin activation, cyclins, key transcriptional genes of osteoblast differentiation and osteoblastic phenotype genes. [Biomaterials] Abstract G-CSF Stimulation of Bone Marrow Mesenchymal Stromal Cells Promotes CD34+ Cell Migration via a Matrix Metalloproteinase-2-Dependent Mechanism Investigators showed that the granulocyte-colony stimulating factor (G-CSF) receptor is expressed by human bone marrow mesenchymal stromal/stem cells (MSCs) and that G-CSF pre-stimulation of MSCs enhances the in vitro trans-stromal migration of CD34+ cells. [Stem Cells Dev] Abstract Diverse Effects of Cyclic AMP Variants on Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stromal Cells Scientists investigated the role of cyclic AMP/protein kinase A signaling in differentiation of human mesenchymal stromal cells. [Tissue Eng Part A] Abstract Donor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells Researchers support the notion that aging is associated with systemic feedback mechanisms acting on stem and progenitor cells, and suggest this is also relevant for serum supplements in cell culture: human platelet lysates derived from younger donors facilitate enhanced expansion and more pronounced osteogenic differentiation. [PLoS One] Full Article Mesenchymal Stem Cells-Derived Interleukin-6 and Vascular Endothelial Growth Factor Promote Breast Cancer Cell Migration By using a small panel of breast cancer cell lines, researchers analyzed the role of interleukin-6 and vascular endothelial growth factor A in the cross-talk between mesenchymal stem cells and breast cancer cells. [J Cell Biochem] Abstract Recombinant Human Bone Morphogenetic Protein-2 Released from Polyurethane-Based Scaffolds Promotes Early Osteogenic Differentiation of Human Mesenchymal Stem Cells Researchers aimed to investigate the pharmacokinetics of recombinant human bone morphogenetic protein-2 (rhBMP-2) from a polyurethane-based porous scaffold and to determine the biological responses of human mesenchymal stem cells to the rhBMP-2 released from those scaffolds. [Biomed Mater] Abstract Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow Scientists examined the effect of recombinant human full-length amelogenin on the osteogenic differentiation of cultured human mesenchymal stem cells. [Cells Tissues Organs] Abstract Effect of Growth Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal Stem Cells In Vitro Researchers investigated cell proliferation and tenogenic differentiation in human mesenchymal stem cells exposed to different concentrations of growth differentiation factor 5. [Cells Tissues Organs] Abstract |