Mesenchymal Cell News Volume 4.23 | Jun 12 2012

Implanted Adipose Progenitor Cells as Physicochemical Regulators of Breast Cancer
Through the integration of physical sciences and oncology approaches, researchers investigated the capability of tumor-derived chemical and mechanical cues to enhance adipose-derived stem cell-mediated contributions to tumor stroma formation. [Proc Natl Acad Sci USA] Abstract

The Electrical Stimulation of Carbon Nanotubes to Provide a Cardiomimetic Cue to MSCs
Researchers tested the hypothesis that electroactive carbon nanotubes could be employed to direct mesenchymal stem cell (MSC) differentiation towards a cardiomyocyte lineage. [Biomaterials] Abstract

GMP-Adapted Overexpression of CXCR4 in Human Mesenchymal Stem Cells for Cardiac Repair
Researchers overexpressed chemokine receptor CXCR4 on human mesenchymal stem cells to improve cell trafficking and tissue repair. [Int J Cardiol] Abstract

Vascular Smooth Muscle Cells Initiate Proliferation of Mesenchymal Stem Cells by Mitochondria Transfer via Tunneling Nanotubes
Investigators studied the differentiation of mesenchymal stem cells (MSC) to vascular smooth muscle cells (VSMC) in a co-culture model using human primary MSC and VSMC. [Stem Cells Dev] Abstract

Mesenchymal Cell Interaction with Ovarian Cancer Cells Triggers Pro-Metastatic Properties
Tumor microenvironment is an important actor of ovarian cancer progression but the relations between mesenchymal cells and ovarian cancer cells remain unclear. Researchers aimed to determine the ovarian cancer cells’ biological modifications induced by mesenchymal cells. [PLoS One] Full Article

Properties and Usefulness of Aggregates of Synovial Mesenchymal Stem Cells as a Source for Cartilage Regeneration
Scientists investigated the handling, properties, and effectiveness of aggregated mesenchymal stem cells for cartilage regeneration. [Arthritis Res Ther] Abstract | Full Article

Wedelolactone Inhibits Adipogenesis through the ERK Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells
The results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells. [J Cell Biochem] Abstract

Perivascular Stem Cells: A Prospectively Purified Mesenchymal Stem Cell Population for Bone Tissue Engineering
Researchers prospectively purified human perivascular stem cells from adipose tissue and compared their bone-forming capacity with that of traditionally derived stromal vascular fraction. [Stem Cells Transl Med] Abstract | Press Release

Distinct Mobilization of Circulating CD271⁺ Mesenchymal Progenitors from Hematopoietic Progenitors during Aging and after Myocardial Infarction
Scientists suggest that CD271⁺ mesenchymal stem cells are mobilized differently from CD133⁺ hematopoietic progenitors and may play a specific role in the tissue repair process during age-related changes and after acute myocardial infarction. [Stem Cells Transl Med] Abstract | Press Release

Mesoblast Provides Corporate Strategy for Product Development to Treat Neurologic Conditions Exclusive Commercial Rights to Develop Neuroregenerative Dental Pulp Stem Cells
Chief Executive Professor Silviu Itescu discussed plans to commercially develop Mesoblast’s proprietary allogeneic adult dental pulp stem cells for stroke, spinal cord injury, Parkinson’s and Huntington’s diseases. [Mesoblast Limited] Press Release

Cryo-Save Begins Long-Term Relationship with Catholic University of Holy Heart
A new collaboration has begun between Cryo-Save and Università Cattolica del Sacro Cuore. The partnership aims at promoting and improving knowledge on the cryopreservation of mesenchymal stem cells from the umbilical cord tissue. [Cryo-Save AG] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 20th Annual World Congress on Anti-Aging Medicine and Biomedical Technologies
December 12-15, 2012
Las Vegas, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellowship – Fibrosis and Mesenchymal Cell Plasticity (Northwestern University)

Development Scientist – Cell Therapy (GE Healthcare)

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